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Soft capsule containing coenzyme Q10 and preparation method and application thereof

A soft capsule and coenzyme technology, applied in the field of new anti-tumor indications of chemical class I new drugs, can solve the problems of lack of controlled trials, insufficient number of cases and treatment plan design, and inability to show effects.

Inactive Publication Date: 2010-10-06
玉溪健坤生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The clinical trial of coenzyme Q10 in foreign countries is used to observe the curative effect of tumor treatment. Although many literature reports can be retrieved, due to the lack of strict controlled trials, there are defects in the number of cases and the design of treatment schemes in different degrees.
In China, although coenzyme Q10 has shown various uses and indications in clinical application, such as anti-oxidation, fatigue relief, and auxiliary blood lipid reduction, etc., due to the limitation of coenzyme Q10 as a medicinal product, the dosage is only 5mg, 10mg, 15mg, The application of coenzyme Q10 is limited, and the effect cannot be shown

Method used

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  • Soft capsule containing coenzyme Q10 and preparation method and application thereof
  • Soft capsule containing coenzyme Q10 and preparation method and application thereof
  • Soft capsule containing coenzyme Q10 and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Recipe: (wherein percentage composition is percentage by weight)

[0023]

[0024] Preparation: prepare 250g of gelatin, 150g of glycerin, 275g of purified water, 0.8g of pigment, and 1g of white pigment (slurry) according to the gelation process (heating, dissolution, vacuum defoaming, standing, and heat preservation) for use. Ingredients Coenzyme Q1050g, perilla oil 200g are prepared according to the content preparation process (weighing, feeding, heating, dissolving). The prepared contents and the gelatinized gelatin were made into pills by the rolling mode "Yixingrui" brand soft capsule capsule process, and the coenzyme Q10 "Yixingrui" brand soft capsules were obtained after shaping, washing, drying, picking and testing. Capsules, specifications: 0.25g per capsule, 60 capsules per bottle (theoretical granulation is 1000 capsules).

Embodiment 2

[0026] formula:

[0027]

[0028] preparation:

[0029]Prepare 300g of gelatin, 180g of glycerin, 330g of purified water, 0.96g of pigment, and 1.2g of white pigment (slurry) according to the gelatinization process (heating, dissolution, vacuum defoaming, standing, and heat preservation) for use as auxiliary materials. 1050g of coenzyme Q, 50g of vitamin E, and 300g of perilla oil are prepared according to the content preparation process (weighing, feeding, heating, dissolving). The prepared contents and the gelatinized gelatin were made into pills by the rolling mode "Yixingrui" brand soft capsule capsule process, and the coenzyme Q10 "Yixingrui" brand soft capsules were obtained after shaping, washing, drying, picking and testing. Capsules, specifications: 0.4g per capsule, 60 capsules per bottle (theoretical granulation is 1000 capsules).

Embodiment 3

[0031] formula:

[0032]

[0033] preparation:

[0034] Prepare 250g of gelatin, 150g of glycerin, 275g of purified water, 0.8g of pigment, and 1g of white pigment (slurry) according to the gelatinization process (heating, dissolution, vacuum defoaming, standing, and heat preservation) as auxiliary materials, and the functional ingredient coenzyme Q1050g, β-carotene 5g, garlic oil 100g, perilla oil 100g, prepared according to the content preparation process (weighing, feeding, heating, dissolving). The preparation contents and the gelatinized liquid are made into pills by the rolling mode soft capsule capsule process, and the coenzyme Q10 "Yixingrui" brand soft capsules are obtained after finalizing, washing the pills, drying, picking up the pills, and testing, specifications: per capsule 0.255g, 60 capsules per bottle (theoretical granulation is 1000 capsules).

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Abstract

The invention discloses a Yixingrui Brand soft capsule containing coenzyme Q10 which can improve immunity and fight against cancers, and a preparation method and application thereof. The preparation method comprises the following steps: using 45-55g of raw medicine containing coenzyme Q10 with content more than or equal to 99 percent as an effective ingredient, using 100-300g of perilla herb oil as solvent, preparing the effective ingredient and the solvent into contents at 40-50 DEG C, proportioning 200-300g of gelatin, 100-250g of glycerin, 250-400g of purified water, 0.8-1.2g of pigment and 1-1.2g of pulpy antholeucin to prepare capsule material, adopting sol to prepare the contents and pressing pellets, conducting processes such as drying, pellet picking and the like of a soft capsule preparation technology, and pressing the material medicine into 1000 Yixingrui Brand soft capsules at 50-55 DEG C through a soft capsule pressing technology. The invention is characterized in that the physical efficacy of the coenzyme Q10 is adopted, solvent, vitamin and minerals with collaborative function are screened and the raw medicine is pressed into pellets by adopting the matured Yixingrui Brand soft capsule preparation technology. According to stability tests, evaluative animal safety tests, hygienic tests and efficacy tests, the invention has the advantages of stable form and efficacy ingredients, no toxic and side effects, strong immunologic function, novel anticancer indication effect and promising application prospect.

Description

technical field [0001] The invention belongs to class I new drug for anti-tumor new indication chemistry, and in particular relates to preparation and application of a dosage form of "Yixingrui" soft capsule containing coenzyme Q10 for enhancing immunity and anti-tumor. Background technique [0002] The human immune function system, the nervous system, and the endocrine system have an extremely complex mutual regulatory relationship. The enhancement of the human immune function shows an anti-tumor effect, prevents the occurrence of tumors, and can also show the killing of tumor cells that have been generated. effect. Cancer is one of the diseases with the highest mortality rate. The morbidity and mortality of cancer are on the rise both at home and abroad. The prevention and treatment of cancer is a key research project in medical research all over the world. With the advancement of biomedical technology, we have a deeper understanding of the causes of cancer. The occurren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/064A61K33/04A61K33/06A61K33/10A61K33/26A61K33/34A61K33/42A61K9/48A61K47/44A61P35/00A61P37/04A61K31/015A61K31/07A61K31/122A61K31/19A61K31/191A61K31/194A61K31/198A61K31/355A61K31/375A61K31/4415A61K31/51A61K31/525A61K31/59A61K31/714A61K31/731
Inventor 陈林先赵士良卿晨丛力
Owner 玉溪健坤生物药业有限公司
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