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Chinese medicinal composition for treating bronchial asthma and preparation method thereof

A technology for bronchial asthma and composition, applied in the field of traditional Chinese medicine composition and preparation thereof, can solve the problems of inconvenience in taking, inability to relieve asthma, large prescription and the like

Inactive Publication Date: 2012-09-26
BEIJING JIABO HONGKANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The long-term curative effect of traditional Chinese medicine compound is significant, but the prescription is large, the onset of effect is slow, and it is inconvenient to take
The single herbal preparations developed in recent years (such as Rhododendron, Vitex, Yangjinhua, etc.) have good curative effects on expectorant and antiasthma clinically, but mainly on expectorant, the antiasthmatic effect is still not comparable to that of many traditional Chinese medicines. side effects, but can relieve symptoms faster than western medicine

Method used

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  • Chinese medicinal composition for treating bronchial asthma and preparation method thereof
  • Chinese medicinal composition for treating bronchial asthma and preparation method thereof
  • Chinese medicinal composition for treating bronchial asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0056] Experimental Example 1 Pharmacodynamics Test

[0057] Experimental Materials:

[0058] Test drug: Xianling Pingchuan dripping pills, 0.05g per pill, 0.45g of crude drug in each pill, batch number: 010909, is a compound preparation of traditional Chinese medicine, provided by the preparation room of the Department of Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine. The preparation is made into 1.95%, 3.9%, 5.85% and 2.7%, 5.4%, 10.8% suspensions (referring to drop pill solution) respectively by distilled water for subsequent use. Dosage design basis: Clinical adults take 20 capsules each time, 3 times a day, a total of 60 capsules a day, taking 3g of finished medicine per day, which is equivalent to 27g of crude medicine per day. Dosage Design Basis: Calculating Animal Dosage Based on Body Surface Area: Mouse 20g = adult dose 3 × 0.0026 = 0.0078g, 0.0078 × 50 = 0.39g / kg (equivalent to 3.51g / kg of crude drug) is the equivalent dose, and...

experiment example 2

[0131] Experimental Example 2 Clinical Experiment

[0132] 【Design types and principles】

[0133] 1. Type of research design: Pilot clinical trial; using segmented random grouping, control (3:1), double-blind research design.

[0134] 2. Sample size required for clinical trial research: sample size: 40 cases.

[0135] 3. Segmented random method: SASV8 software was used to conduct segmented random grouping; 40 inpatients or outpatients were divided into a treatment group and a control group, with 30 cases in the treatment group and 10 cases in the control group.

[0136] 4. Blind design

[0137] A double-blind measurement method was adopted; the researchers (measurers, namely medical technicians, data managers and statistical analysis workers) and the research objects (patients) were blinded.

[0138] 5. Comparison

[0139] Experimental group: routine western medicine treatment + Xianling Pingchuan prescription

[0140] Control group: routine western medicine treatment + c...

experiment example 3

[0256] Experimental Example 3 Preparation Research

[0257] 1. Selection of substrate

[0258] Most of the medicinal ingredients in the composition of the present invention are large molecular weight, poorly soluble substances, and thermally unstable ingredients. In order to improve drug dissolution and maximize drug loading, the selection of the matrix is ​​very important.

[0259] The bases of dropping pills can be divided into two categories: fat-soluble and water-soluble. Sexual bases include polyethylene glycols, sodium stearate, urea polyether poloxamer, etc.

[0260] The preliminary test shows that when PEG4000 is used as the matrix, the hardness, roundness and heat resistance of the dropping pills are poor.

[0261] In this test, the roundness and hardness of the dropping pills are used as indicators, and the mixture of the two in different proportions is investigated as the matrix. The roundness refers to the ratio of the shortest diameter to the longest diameter o...

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Abstract

The invention discloses a Chinese medicinal composition for treating bronchial asthma and a preparation method thereof. The Chinese medicinal composition comprises the following raw material medicaments in part by weight: 5 to 20 parts of pungent oleaster leaf, 4 to 18 parts of epimedium brevicornum and 2 to 12 parts of Chinese magnoliavine fruit. Capsules, tablets, granules, gels, slow-release formulations, oral liquid or pills are prepared by extracting pungent oleaster leaf, the epimedium brevicornum and the Chinese magnoliavine fruit through a conventional process method and adding pharmaceutically-acceptable auxiliary materials into the extract. The Chinese medicinal composition has the excellent effects of relieving asthma and stopping cough and reinvigorating and consolidating the constitution.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating bronchial asthma and a preparation method thereof. Background technique [0002] Bronchial asthma (Bronchial athma) is a clinically common, refractory, emergency and severe disease mainly manifested by bronchospasm, which belongs to the category of asthma (asthma) disease in traditional Chinese medicine. According to the latest statistics from the World Health Organization, there are about 160 million patients in the world. The prevalence rate of asthma in the United States is as high as 4%, Japan is 3%, Italy is 5% in rural areas, 7% in cities, and my country is about 2%. million patients. Along with the development of industry, the air pollution is serious, the source of allergies in the living environment increases, the incidence of asthma rises, and the incidence of asthma of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57A61P11/06
Inventor 卢印英
Owner BEIJING JIABO HONGKANG PHARMA TECH