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Composition for treating cardiovascular diseases

A composition and drug technology, applied in the direction of cardiovascular system diseases, metabolic diseases, drug combinations, etc., to achieve the effect of easy portability and simple administration

Inactive Publication Date: 2010-11-17
北京华禧联合科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, atorvastatin does not seem to have significant enterohepatic recirculation

Method used

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  • Composition for treating cardiovascular diseases
  • Composition for treating cardiovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription 1: Each tablet (mg)

[0022] Azedipine 8

[0023] Atorvastatin Calcium 10

[0024] Calcium carbonate 47

[0025] Microcrystalline Cellulose 60

[0026] Mannitol 30

[0027] Proper amount of hypromellose

[0028] Crospovidone 4

[0029] Magnesium Stearate 1

[0030] Preparation process: pass the main drug and auxiliary materials through a 100-mesh sieve. Mix the excipients except magnesium stearate evenly, make soft material with 2% hypromellose aqueous solution, granulate with 18 mesh sieve, dry at 60°C, granulate with 18 mesh sieve, add magnesium stearate and mix well , Φ8mm punch tablet.

Embodiment 2

[0032] Prescription 2: per tablet (mg)

[0033] Azedipine 8

[0034] Atorvastatin Calcium 20

[0035] Calcium carbonate 30

[0036] Microcrystalline Cellulose 50

[0037] Lactose 46

[0038] Proper amount of povidone

[0039] Crospovidone 5

[0040] Magnesium Stearate 1

[0041] Preparation process: pass the main drug and auxiliary materials through a 100-mesh sieve. Mix the excipients except magnesium stearate evenly, make soft material with 8% povidone aqueous solution, granulate with 18 mesh sieve, dry at 60°C, granulate with 18 mesh sieve, add magnesium stearate and mix evenly, Φ8mm Punch tablet.

Embodiment 3

[0043] Prescription 3: Each tablet (mg)

[0044] Azedipine 8

[0045] Atorvastatin Calcium 40

[0046] Calcium hydrogen phosphate 37

[0047] Microcrystalline Cellulose 40

[0048] Mannitol 30

[0049] Proper amount of hypromellose

[0050] Croscarmellose Sodium 4

[0051] Magnesium Stearate 1

[0052] Preparation process: pass the main drug and auxiliary materials through a 100-mesh sieve. Mix the excipients except magnesium stearate evenly, make soft material with 2% hypromellose aqueous solution, granulate with 18 mesh sieve, dry at 60°C, granulate with 18 mesh sieve, add magnesium stearate and mix well , Φ8mm punch tablet.

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Abstract

The invention relates to a medicinal composition containing azelnidipine and atorvastatin calcium, which is used for reducing blood pressure and blood fat and reducing risks of myocardial infarction and cerebral apoplexy.

Description

technical field [0001] The invention relates to a pharmaceutical composition of azedipine and its pharmaceutically acceptable salt, atorvastatin and its pharmaceutically acceptable salt and a preparation method thereof, which can be used for treating patients with angina pectoris, atherosclerosis and combined hypertension and hyperlipidemia It is easy to carry and easy to take for patients with heart disease and patients with heart risk symptoms. [0002] [0003] Azedipine [0004] [0005] Atorvastatin Calcium Background technique [0006] Azedipine, chemical name (±)-3-(1-benzhydrylazetidin-3-yl)5-isopropyl-2-amino-1,4-dihydro-6-methyl -4-(3-nitrophenyl)-3,5-pyridinedicarboxylate is a calcium antagonist antihypertensive drug, the main mechanism of action is to inhibit the influx of extracellular calcium. For blood vessels, through It relaxes smooth muscle and dilates blood vessels to lower blood pressure. Compared with other calcium antagonist antihypertensive dr...

Claims

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Application Information

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IPC IPC(8): A61K31/4427A61K31/40A61P9/10A61P9/12A61P3/06A61P9/04
Inventor 王玉莉尤广智胡淑娟毕华张志芳
Owner 北京华禧联合科技发展有限公司
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