Cefozopran hydrochloride for injection and preparation method thereof

A technology for cefozopran hydrochloride and injection, which is applied in the field of cefozopran hydrochloride for injection and its preparation, can solve the problems of increasing the incidence of adverse reactions, etc., and achieve the effects of reducing dosage, good therapeutic effect, and reducing adverse reactions

Inactive Publication Date: 2010-11-24
王艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cefzoram hydrochloride powder injection prepared by using this prescription and process requires each injection of 1000 mg of the main drug to achieve the therapeutic effect, which indirectly increases the incidence of adverse reactions of the drug

Method used

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  • Cefozopran hydrochloride for injection and preparation method thereof
  • Cefozopran hydrochloride for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The preparation of embodiment 1 injection cefozopran hydrochloride

[0066] prescription:

[0067] Cefazolam Hydrochloride 500g

[0068] Soy Lecithin 800g

[0069] Cholesterol 350g

[0070] Anhydrous sodium carbonate 65g

[0071] Glucose 60g

[0072] Preparation Process:

[0073] 1) Take soybean lecithin and cholesterol of prescription quantity, make it dissolve with dehydrated alcohol, mix uniformly;

[0074] 2) Place the liposome liquid prepared in step 1) on a thin wax evaporator, remove ethanol under reduced pressure, and prepare a phospholipid film;

[0075] 3) Immerse an appropriate amount of citric acid-sodium citrate buffer solution with a pH of 4.8 into the phospholipid membrane. After the phospholipid is completely hydrated, prepare liposomes with a high-pressure homogenizer. After checking that the particle size of the liposomes is qualified, microporous filtration Sterilize by membrane filtration, measure the amount of phospholipids with the molybdenu...

Embodiment 2

[0080] The preparation of embodiment 2 injection cefozopran hydrochloride

[0081] prescription:

[0082] Cefazolam Hydrochloride 1000g

[0083] Soy Lecithin 2000g

[0084] Cholesterol 400g

[0085] Anhydrous sodium carbonate 100g

[0086] Glucose 80g

[0087] Preparation process: with embodiment 1

Embodiment 3

[0088] The preparation of embodiment 3 injection cefozopran hydrochloride

[0089] prescription:

[0090] Cefazolam Hydrochloride 200g

[0091] Soy Lecithin 425g

[0092] Soy Lecithin 800g

[0093] Cholesterol 350g

[0094] Anhydrous sodium carbonate 65g

[0095] Glucose 60g

[0096] Preparation Process:

[0097] 1) Take soybean lecithin and cholesterol of prescription quantity, make it dissolve with dehydrated alcohol, mix uniformly;

[0098] 2) Place the liposome liquid prepared in step 1) on a thin wax evaporator, remove ethanol under reduced pressure, and prepare a phospholipid film;

[0099] 3) Immerse an appropriate amount of citric acid-sodium citrate buffer solution with a pH of 4.8 into the phospholipid membrane. After the phospholipid is completely hydrated, prepare liposomes with a high-pressure homogenizer. After checking that the particle size of the liposomes is qualified, microporous filtration Sterilize by membrane filtration, measure the amount of phos...

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PUM

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Abstract

The invention belongs to the field of medical preparations, and relates to cefozopran hydrochloride for injection and a preparation method thereof. The cefozopran hydrochloride for injection comprises the following components in part by weight: 200 to 1,000 parts of cefozopran hydrochloride, 350 to 2,000 parts of soybean lecithin, 150 to 450 parts of cholesterol, 45 to 100 parts of anhydrous sodium carbonate and 25 to 85 parts of glucose. The cefozopran hydrochloride for injection can achieve better treatment effect on the basis of low content of a main ingredient, and simultaneously reduces the incidence rate of untoward effect, so the product is more safe and effective.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to cefozopram hydrochloride for injection and a preparation method thereof. Background technique [0002] Cefozopran hydrochloride is the fourth-generation cephalosporin for injection developed by Takeda Pharmaceutical Co., Ltd. in Japan. It has been widely used in various infections including neonatal infections in Japan as the drug of choice in the early stage of out-of-hospital infections. disease treatment. In addition to MRSA, it has broad-spectrum activity, and its activity against Gram-positive bacteria is generally superior to that of ceftazidime, cefpime and flumoxef, and comparable to that of cefpirome, and it has the same activity against Gram-negative bacteria as the above-mentioned control drugs active. It is highly stable to β-lactamase, widely distributed in the body, and has high plasma and tissue concentrations. Most of it is excreted in urine in the form ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/127A61P31/04
Inventor 王艳
Owner 王艳
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