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Composition containing folic acid and B vitamins and applications thereof

A technology of B vitamins and compositions, applied to compositions containing folic acid and B vitamins and the fields of their uses, can solve problems such as unfavorable clinical medical progress, increased demand and the like

Inactive Publication Date: 2010-12-01
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no compound drug of folic acid, vitamin B6, and vitamin B12 on the market. This is contradictory to the increasingly deepened understanding of the effects of folic acid, vitamin B6, and vitamin B12 in clinical practice, and the increasing demand for its compound drug. It is also not conducive to the progress of clinical medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Preparation of compound folic acid and VB6 tablets (1000 tablets)

[0044] Formula composition:

[0045] Folic acid 0.2g

[0046] VB6 5g

[0047] Lactose 50.0g

[0048] Starch 10.0g

[0049] Microcrystalline cellulose 50.0g

[0050] Sodium Carboxymethyl Starch (CMS·Na) 30.0g

[0051] 10% povidone K-30 (solvent is anhydrous ethanol) appropriate amount

[0052] Magnesium stearate

[0053] Preparation Process:

[0054] Crush 0.2g folic acid, 5g VB6, 50g lactose, 50g microcrystalline cellulose, and 10g starch, pass through a 120-mesh sieve, and mix uniformly according to the equal-volume addition method. Use an appropriate amount of 10% polyketone ethanol solution to make a soft material. Granulate, dry, sizing, mix the granules with a water content of about 3% and an appropriate amount of magnesium stearate uniformly, and make 1000 tablets according to the conventional method.

Embodiment 2

[0055] Example 2: Preparation of compound folic acid and VB12 tablets (1000 tablets)

[0056] Formula composition:

[0057] Folic acid 0.4g

[0058] VB12 0.5g

[0059] Lactose 45.0g

[0060] Starch 45.0g

[0061] Microcrystalline cellulose 45.0g

[0062] Sodium Carboxymethyl Starch (CMS·Na) 5.0g

[0063] 5% povidone K-30 (solvent is anhydrous ethanol) appropriate amount

[0064] Magnesium stearate

[0065] The preparation process is the same as in Example 1.

Embodiment 3

[0066] Example 3: Preparation of folic acid, VB12, VB6 tablets (1000 tablets)

[0067] Formula composition:

[0068] Folic acid 0.8g

[0069] VB12 1g

[0070] VB6 10g

[0071] Starch 45.0g

[0072] Microcrystalline cellulose 45.0g

[0073] Sodium Carboxymethyl Starch (CMS·Na) 5.0g

[0074] 5% povidone K-30 (solvent is anhydrous ethanol) appropriate amount

[0075] Magnesium stearate

[0076] The preparation process is the same as in Example 1.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing folic acid and B vitamins and applications thereof in preparing medicines for preventing and treating hyperhomocysteinemia or diseases accompanied with homocysteine rise. The B vitamins are one or a plurality of vitamin B6, vitamin B12, vitamin B1, vitamin B2, vitamin PP, biotin and pantothenic acid. Folic acid and B vitamins can cooperate to reduce the Hcy level and reduce damage of Hcy. The composition provides an effective scheme for treating hyperhomocysteinemia or diseases accompanied with homocysteine rise. The invention belongs to the field of pharmacy.

Description

Technical field [0001] The invention relates to a pharmaceutical composition containing folic acid and B vitamins and its use in preparing a medicine for treating hyperhomocysteinemia or diseases accompanied by elevated homocysteine. It belongs to the field of pharmacy. Background technique [0002] Homocysteine ​​(Hcy) is an important intermediate product in the metabolism of sulfur-containing amino acids. The human body mainly regulates its metabolism through two pathways. The first is that Hcy accepts the methyl group provided by N-methyltetrahydrofolate to regenerate methionine. The enzyme that catalyzes this reaction is called methionine synthase, and its cofactor is VB12. This reaction is currently It is known that the only reaction in the body that can utilize N-methyltetrahydrofolate, and the storage form of folic acid in the body is N-methyltetrahydrofolate; the second way is that Hcy can be catalyzed by cystathionine-β-synthetase, Condensed with serine to produce cyst...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K31/4415A61K31/714A61K31/51A61K31/525A61K31/455A61K31/4188A61K31/197A61P9/10A61P7/02A61P9/00A61P25/00
Inventor 余虹宇于多徐希平
Owner 北京奥萨医药研究中心有限公司
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