Method for extracting and separating laburnine

A technology of genistein and a separation method, which is applied in directions such as organic chemistry, can solve the problems of long cycle, low genistein content, complicated process, etc., and achieves the effects of low production cost, reduced production cost and rational development.

Active Publication Date: 2012-05-30
SHAANXI JIAHE PHYTOCHEM
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a method for extracting and separating cytisine, which mainly solves the problems of low content of cytisine extracted by the existing method, complex process and long period

Method used

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  • Method for extracting and separating laburnine
  • Method for extracting and separating laburnine
  • Method for extracting and separating laburnine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Extraction: get cytisine content and be that 100kg of the herbivorous bean raw material of 1.2% is pulverized; The raw material of above-mentioned treatment gained is passed through 10 mesh sieves; Then the raw material of gained is 80% with the volume concentration of 5 times of raw material weight The methanol extraction, the extraction temperature is 60 ° C, extraction 3 times, each extraction 2 hours, to obtain the extract;

[0052] (2) Concentration: the extracts are combined, concentrated under reduced pressure until there is no alcohol smell, and a concentrated solution is obtained;

[0053] (3) Alkali adjustment: adding mass concentration to the concentrated solution is 5% sodium hydroxide solution to make the pH=10 of the concentrated solution;

[0054] (4) Extraction: extract the concentrated solution obtained through the treatment of step (3) with ethyl acetate to obtain an extract; the number of extractions is 3 times, and the volume of the extraction so...

Embodiment 2

[0072] (1) Extraction: get cytisine content and be that 100kg of Sophora sophora raw material of 0.6% is pulverized; The raw material of above-mentioned treatment gained is passed through 20 mesh sieves; Then the raw material of gained is 60% with the volume concentration of 6 times of raw material weight. Methanol extraction, the extraction temperature is 80°C, extraction 3 times, each extraction 1.5 hours, to obtain the extract;

[0073] (2) Concentration: the extracts are combined, concentrated under reduced pressure until there is no alcohol smell, and a concentrated solution is obtained;

[0074] (3) Alkali adjustment: add strong ammonia water to the concentrated solution to make the concentrated solution pH=9;

[0075] (4) Extraction: extract the concentrated solution obtained through the treatment of step (3) with dichloromethane to obtain an extract; the number of extractions is 2 times, and the volume of the extraction solvent is 4 times the volume of the concentrated...

Embodiment 3

[0093] (1) Extraction: get cytisine content and be that 100kg of Sophora alopecuroides raw material of 0.56% is pulverized; The raw material of above-mentioned processing gained is passed through 20 mesh sieves; Then the raw material of gained is 90% with the volume concentration of 4 times of raw material weight. Ethanol extraction, extraction temperature is 75°C, extraction is 3 times, each extraction takes 1.5 hours to obtain extract;

[0094] (2) Concentration: the extracts are combined, concentrated under reduced pressure until there is no alcohol smell, to obtain a concentrated solution;

[0095] (3) Alkali adjustment: adding mass concentration to the concentrated solution is 10% potassium hydroxide to make the concentrated solution pH=11;

[0096] (4) Extraction: the mixed system that the volume ratio of sherwood oil and ethyl acetate is 1: 3 is extracted with the solution obtained through step (3) processing, obtains extract; The number of times of extraction is 2 time...

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Abstract

The invention provides a method for extracting and separating laburnine, mainly solving the problems of low purity, complicated process and long period of the traditional method while extracting and separating the laburnine. The method for extracting and separating the laburnine comprises the following steps of: (1) extracting; (2) concentrating; (3) regulating the laburnine; (4) extracting; and (5) continuous medium pressure column chromatography. The method has the advantage of definite purpose, and not only can be used for obtaining laburnine with the content higher than 98 percent, but also can be used for enriching other alkaloids, such as sophoridine, sophoramine, sparteine, and the like, in the separation process, thereby further reducing the production cost and sufficiently utilizing and reasonably developing raw materials.

Description

technical field [0001] The invention relates to a method for extracting and separating alkaloids, in particular to a method for extracting and separating cytisine. Background technique [0002] Publication No. CN1003936B "Comprehensive Utilization Method of Bitter Bean" on April 19, 1989 discloses a method for comprehensive utilization of bitter bean. The main method is to soak bitter beans in acid solution to detoxify first to obtain high-protein feed, and continuously extract sophocarpine, aloperine, sophoridine, matrine, oxymatrine, and sophoramine by extraction And cytisine etc. This invention only obtains sophocarpine, aloperine, sophoridine, matrine, oxymatrine, sophoramine and cytisine through simple pickling and extraction, and the cytisine extracted according to this method The content is low, and the process method is vague and the technical content is low. [0003] On February 27, 2008, the publication number was CN101129455A "Sophora Sophora Extract and Its Pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D471/18C07D471/22
Inventor 王春德邓尚勇肖红金富林
Owner SHAANXI JIAHE PHYTOCHEM
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