Compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof

A technology of polyhexamethylene guanidine and disinfectant, which is applied to the active ingredients of artificially synthesized polymer materials, drug combinations, and pharmaceutical formulas, which can solve the problems of easy to produce drug-resistant bacteria and slow onset of action, and achieve excellent moisturizing Action, irritation reduction, excellent lubricating effect

Inactive Publication Date: 2010-12-29
SHANGHAI LIKANG DISINFECTION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyvinylpyrrolidone-iodine (PVP-I) is a complex formed between iodine and polymer compound polyvinylpyrrolidone, which can continuously release free iodine and exert long-acting effects, but has the disadvantage of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Add 10 grams of polyvinylpyrrolidone iodine to 271 grams of water, stir to dissolve; add 3 grams of fatty alcohol polyoxyethylene ether (Aeo9), 10 grams of glycerin, and 1 gram of citric acid in sequence, and stir to dissolve; add 700 grams of ethanol, stir and mix evenly Add 5 grams of polyhexamethyleneguanidine and stir evenly to obtain the compound polyhexamethyleneguanidine complex iodine disinfectant.

Embodiment 2

[0033] Add 20 grams of polyvinylpyrrolidone iodine to 351 grams of water, stir to dissolve; add 5 grams of nonylphenol polyoxyethylene ether-10 (TX-10), 10 grams of glycerin, 10 grams of polyethylene glycol, and 1 gram of citric acid , stir and dissolve; add 600 grams of ethanol, stir and mix uniformly; add 3 grams of polyhexamethyleneguanidine, stir well, and obtain the described compound polyhexamethyleneguanidine complex iodine disinfectant.

Embodiment 3

[0035] 50 grams of polyvinylpyrrolidone iodine was added to 576 grams of water, stirred and dissolved; 10 grams of polyoxyethylene sorbitan monooleate (Tween80), 10 grams of polyethylene glycol, and 2 grams of citric acid were added successively, stirred and dissolved; Add 350 grams of ethanol, stir and mix evenly; add 2 grams of polyhexamethyleneguanidine, stir evenly, and obtain the compound polyhexamethyleneguanidine complex iodine disinfectant.

[0036] The above-mentioned disinfectants of each embodiment, under the condition of 19-21 ℃, act for 1 minute, and the average killing logarithm values ​​of Staphylococcus aureus, Escherichia coli, Candida albicans, and Pseudomonas aeruginosa are all>5.00. The results of the accelerated stability test showed that the content of polyhexamethyleneguanidine decreased by less than 3%, that of available iodine decreased by less than 8%, and that of ethanol decreased by less than 6% when stored at a constant temperature of 37°C for 90 da...

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PUM

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Abstract

The invention relates to a compound polyhexamethylene guanidine complexing iodine disinfector and a preparation method thereof. The compound polyhexamethylene guanidine complexing iodine disinfector comprises the following components in percentage by mass: 0.1-0.5 percent of polyhexamethylene guanidine, 0.5-5 percent of PVP-I (polyvinylpyrrolidone iodine), 30-70 percent of ethanol, 0.1-1 percent of non-ionic surface active agent, 0.5-3 percent of skin-protecting agent, 0.05-0.2 percent of citric acid and the balance of water. The preparation method of the compound polyhexamethylene guanidine complexing iodine disinfector comprises the following steps of: adding polyvinylpyrrolidone iodine into the water according to the content and the components, and stirring the mixture to dissolve; sequentially adding the non-ionic surface active agent, the skin-protecting agent and the citric acid, and stirring the mixture to dissolve; adding and stirring ethanol to the mixture uniformly; and adding and stirring polyhexamethylene guanidine to the mixture uniformly to obtain the compound polyhexamethylene guanidine complexing iodine disinfector. The compound polyhexamethylene guanidine complexing iodine disinfector has the characteristics of stable characteristics, quick and lasting sterilization function, low simulation to skins, quick drying and convenient use.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a compound polyhexamethyleneguanidine complexed iodine disinfectant and a preparation method thereof. Background technique [0002] Polyhexamethyleneguanidine is a broad-spectrum, quick-acting fungicide, which acts on the cell wall and cytoplasmic membrane system of bacteria and fungi, combines with fatty acids in the cell membrane phospholipids, quickly penetrates their cytoplasmic membranes, and breaks through the pathogenic cells. The core, so that the living matter in the pathogenic bacteria outflows, so as to achieve the bactericidal effect. Used in combination with other fungicides, it can exert an excellent disinfection effect. Because polyhexamethyleneguanidine has a non-specific mode of killing bacteria, it is very unlikely that bacteria will develop resistance to it. [0003] Iodine is a commonly used disinfectant that destroys the outer layer of bacteria by iodination. Polyvinylpyr...

Claims

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Application Information

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IPC IPC(8): A61K31/79A61K31/785A61P31/00
Inventor 张万国孙文胜卞雪莲
Owner SHANGHAI LIKANG DISINFECTION HIGH TECH
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