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Comprehensive two-dimensional ultrahigh pressure high performance liquid chromatography separation system

A high-pressure liquid chromatography and high-performance liquid chromatography technology, which is applied in the field of high-performance liquid chromatography separation systems, can solve problems such as dilution, reduce sample detection sensitivity, and speed up the second-dimensional separation time to achieve fast and efficient separation, fast and effective separation Effect

Active Publication Date: 2013-02-13
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the monolithic column is mainly used as the second-dimensional column to speed up the separation time of the second dimension. However, due to the excessive flow rate of the monolithic column, it will cause dilution of subsequent injection samples and reduce the detection sensitivity of the sample.

Method used

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  • Comprehensive two-dimensional ultrahigh pressure high performance liquid chromatography separation system
  • Comprehensive two-dimensional ultrahigh pressure high performance liquid chromatography separation system
  • Comprehensive two-dimensional ultrahigh pressure high performance liquid chromatography separation system

Examples

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example

[0022]Prepare a mixed solution of standard samples containing 37 components, 1.1,3-difluorobenzene (1,3-difluorobenzene), 2.nonanophenone (nonaphenone), 3.nitrobenzene (nitrobenzene), 4.benzyl butylphthalate (Benzyl butyl phthalate), 5.2,4-dinitrochlorobenzene (1-chloro-2,4-dinitrobenzene), 6.thioanisole (anisole sulfide), 7.bromobenzene (bromobenzene), 8 .acetophenone (acetophenone), 9.1, 4-bis(trifluoromethyl)benzene (1,4-bis(trifluoromethyl)benzene), 10.octanophenone (phenyloctyl ketone), 11.1,3-bis(trifluoromethyl)benzene (1,3-bis(trifluoromethyl)benzene), 12.anisole (anisole), 13.butylbenzene (n-butylbenzene), 14.ethylbenzene (ethylbenzene), 15.hexanophenone (n-hexylbenzene) , 16.heptanophenone (n-heptylbenzene), 17.fluorobenzene (fluorobenzene), 18.a, a, a, -trifluorotoluene (a, a, a- trifluorotoluene), 19.diethyl phthalate (phthalic acid Diethyl ester), 20.triptycene (triptycene), 21.indolebenzene (iodobenzene), 22.benzene (benzene), 23.pentylbenzene (amylbenzene) (ben...

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Abstract

The invention provides a comprehensive two-dimensional ultrahigh pressure high performance liquid chromatography (HPLC) separation system which comprises a liquid chromatography solvent delivery pump, a liquid chromatographic column, a dosing ring, a two-position ten-way valve, a detector and a sample injector. The comprehensive two-dimensional HPLC separation system realizes rapid separation of a second-dimensional chromatograph, meets the requirement of a comprehensive two-dimensional chromatograph on the separation speed of the second-dimensional chromatograph, and realizes ultra strong separation capability of the comprehensive two-dimensional HPLC separation system by introducing the ultrahigh pressure liquid chromatography solvent delivery pump, the high-pressure ten-way valve and the ultrahigh pressure liquid chromatographic column. The comprehensive two-dimensional HPLC separation system is characterized in that a first-dimensional chromatograph can keep a sample at a certain separation degree at low flow rate by adopting a long column with small inside diameter, and the time for filling first-dimensional effluent in the dosing ring is prolonged at the low flow rate so as to leave sufficient separation time for the second-dimensional chromatograph; and the second-dimensional chromatograph can realize rapid and efficient separation of the sample thereon by adopting an ultrahigh pressure chromatograph short column with small particle size. The comprehensive two-dimensional ultrahigh pressure HPLC separation system can realize rapid and effective separation of the samples in the fields such as environment, plants, metabonomics and the like by combination of chromatographic columns with different stationary phases.

Description

technical field [0001] The invention relates to a high performance liquid chromatography separation system, in particular to a comprehensive two-dimensional high performance liquid chromatography separation system in which ultra-high pressure fast liquid chromatography is the second dimension. Background technique [0002] With the development of modern life sciences, food safety, environmental monitoring and medical health, the separation of complex sample systems has become an important direction of analytical chemistry research. Compared with one-dimensional chromatography, multidimensional chromatography greatly improves the peak capacity and separation selectivity of the entire separation system, and has become a research hotspot in the separation and analysis of complex systems. Multidimensional liquid chromatography is a liquid chromatography technique in which the eluent from the first dimension of the sample is sequentially injected into the subsequent dimension of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 丁丽谢复炜王昇郭吉兆颜权平余晶晶刘绍锋张晓兵
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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