Zinc gluconate sugar tablet preparation and preparation method thereof

A technology of zinc gluconate and glucose syrup, which is applied in the field of medicine, can solve the problems of strong irritation of nasal mucosa, unsatisfactory curative effect of colds, and limited clinical application, so as to avoid metallic taste, be happy to take, and control the quality

Active Publication Date: 2012-03-28
莱阳司邦得制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In China, zinc gluconate preparations are used as zinc supplements in large quantities, and there are few products for treating colds. The zinc gluconate nasal spray produced by domestic enterprises has strong irritation to the nasal mucosa due to the nasal spray, and According to relevant data, the use of zinc gluconate nasal spray may cause permanent loss of smell, which is difficult for patients to accept clinically.
[0004] Chinese patent document CN1091638A (CN93101972.9) discloses a kind of anti-cold Zinc Kekang, main medicine is zinc gluconate, ibuprofen, chlorpheniramine, is processed into tablet capsule or electuary, relevant domestic and foreign reports zinc gluconate directly Gastrointestinal oral administration is unsatisfactory in the treatment of colds
Due to the above various deficiencies, existing zinc gluconate cold preparation products are greatly limited in clinical application

Method used

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  • Zinc gluconate sugar tablet preparation and preparation method thereof
  • Zinc gluconate sugar tablet preparation and preparation method thereof
  • Zinc gluconate sugar tablet preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation of embodiment 1, zinc gluconate sugar tablet

[0063] 1. The proportion of raw and auxiliary materials:

[0064] Zinc gluconate: white sugar: malt syrup: glycine: fruit flavoring agent: purified water = 93.24: 1460: 2910 (solid content): 30: 30: 438 (mass ratio W / W)

[0065] 2, the preparation method, the steps are as follows:

[0066] (1) Take by weighing 1.865kg of zinc gluconate, 0.6kg of glycine, 29.2kg of white sugar, 58.2kg of maltose syrup (solid content), 8.76kg of purified water and 0.6kg of fruit flavoring agent for seasoning by prescription.

[0067] (2) Add the weighed white sugar, maltose syrup and purified water into the dissolution tank, start stirring, heat up to 80-90°C, and dissolve it completely; put in spare zinc gluconate and glycine, and continue stirring for 10 minutes, After completely dissolved. Turn on the vacuum pump and pump the fully dissolved sugar solution into the vacuum sugar evaporator (preheated to 90-100°C).

[006...

Embodiment 2

[0073] The preparation of embodiment 2, zinc gluconate sugar tablet

[0074] 1. The proportion of raw and auxiliary materials:

[0075] Zinc gluconate: white sugar: malt syrup: glycine: fruit flavoring agent: purified water = 93.24: 1880: 3750 (solids): 39: 39: 565 (mass ratio W / W)

[0076] 2, the preparation method, the steps are as follows:

[0077] 1) Take by weighing 1.865kg of zinc gluconate, 0.78kg of glycine, 37.6kg of white sugar, 75kg of malt syrup (solid content), 11.3kg of purified water and 0.78kg of fruit flavoring agent for seasoning according to the prescription.

[0078] 2) Add the weighed white sugar, maltose syrup and purified water into the dissolving tank, start stirring, heat up to 80-90°C to make it completely dissolved; put in spare zinc gluconate and glycine, continue stirring for 10 minutes, completely Once dissolved; add flavored fruit flavor. Turn on the vacuum pump and pump the fully dissolved sugar solution into the vacuum sugar evaporator (preh...

Embodiment 3

[0083] The preparation of embodiment 3, zinc gluconate sugar tablet

[0084] 1. The proportion of raw and auxiliary materials:

[0085] Zinc gluconate: white sugar: glucose syrup: glycine: fruit flavoring agent: purified water = 93.24: 1670: 3330 (fold solid): 35: 35: 502 (mass ratio W / W)

[0086] 2, the preparation method, the steps are as follows:

[0087] (1) Take by weighing 1.865kg of zinc gluconate, 0.7kg of glycine, 33.4kg of white sugar, 66.6kg of glucose syrup (solid content), 10kg of purified water and 0.7kg of fruit flavoring agent for seasoning by prescription.

[0088] The operations of (2)-(4) are the same as the corresponding steps (2)-(4) of Embodiment 1.

[0089] (5) Control the temperature of the kneaded and uniform massecuite at 70-80°C, send it to the heat preservation roller bed machine and roll it into strips, then enter the strip machine to draw uniform and suitable sugar strips and enter the punching machine, Regulate the pressure of punching machine...

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Abstract

The invention relates to a zinc gluconate sugar tablet preparation and a preparation method thereof. The sugar tablet comprises the following components by mass: 93.24-160 parts of zinc gluconate and pharmaceutic excipients such as 1460-2500 parts of white sugar, 2910-5000 parts of maltose syrup or glucose syrup, 30-52 parts of glycine, 438-750 parts of purified water and 30-52 parts of fruit flavoring agents. The preparation is prepared by dissolving sugar at high temperature, boiling sugar under vacuum, etc. The form of the preparation is semi-transparent hard sugar tablet and the preparation is the buccal tablet. The sugar tablet is dissolved in the mouth, so that the zinc ions can permeate the nose, throat and susceptible tissues in the nasal sinus to be combined with the influenza virus receptor to prevent the influenza virus from further spreading among the cells so as to achieve the aims of treating cold and alleviating cold symptoms.

Description

technical field [0001] The invention relates to a pharmaceutical preparation of zinc gluconate sugar tablet for treating colds and alleviating symptoms of colds and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Influenza is one of the most common diseases in the world and one of the major public health problems faced by human beings. According to statistics, the annual incidence of cold is 10%-30%, and tens of thousands of people are infected every year all over the world. Almost no one has never had a cold in life. Symptoms are: nasal congestion, runny nose, sneezing, coughing, fever, body aches, etc. If not treated in time, it can induce pharyngitis, otitis media, bronchitis, pneumonia, and other diseases. [0003] In China, zinc gluconate preparations are used as zinc supplements in large quantities, and there are few products for treating colds. The zinc gluconate nasal spray produced by domestic enterprises ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/191
Inventor 乔敏袁武杰徐彦刘钢滕学厚
Owner 莱阳司邦得制药有限公司
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