Preparation method of plumbagin
A technique of plumbagin and leaching method, applied in the field of preparation of plumbagin, can solve the problems of low purity, inability to meet the needs of research and future market demands, and low extraction rate, and achieves high extraction purity and equipment. The effect of low requirements and large adsorption capacity
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0022] 2 kilograms of Plumbago, artificially chopped into raw materials of 1mm, put into the still, add deionized water in the still, the addition is 2 times of the raw material by weight, the extraction time is 10 hours, and the oil and water are separated to obtain Plumbagin crude product 32g, dissolve crude product with a small amount of ethanol, go up macroporous adsorption resin column D101, 2 times of column volume deionized water elute impurity, then use sherwood oil-acetone (20:1), sherwood oil-acetone ( 10:1) and acetone-methanol (1:1) for 3 times column volume elution, collect the target eluent under the guidance of thin layer chromatography and recover the solvent, concentrate and dry, add 70% ethanol to heat and reflux to saturate and dissolve, cool , deionized water was slowly added dropwise, left to stand for crystallization, and dried to obtain 6 g of the product with a content of 96%. Check with a silica gel plate, wherein the silica gel plate is made of CMC-Na...
Embodiment 2
[0024] 2 kilograms of Plumbago, pulverized into a raw material product of 1 mm with a tissue pulverizer, put into the still, add deionized water in the still, the amount added is 2.5 times of the amount of raw material by weight, the extraction time is 8 hours, and the oil and water are separated , obtain plumbagin crude product 28g, dissolve crude product with a small amount of ethanol, go up macroporous adsorption resin column D101, 2 times column volume deionized water elutes impurity, then respectively use petroleum ether-acetone (10:1), petroleum ether- Acetone (5:1) and acetone-methanol (1:3) were eluted with 3 times the column volume each. Under the guidance of thin layer chromatography, the target eluent was collected and the solvent was recovered, concentrated to dryness, and heated to reflux with 80% ethanol to saturate and dissolve , cooled, slowly added deionized water dropwise, left to stand for crystallization, and dried to obtain 5.3g of product with a content of...
Embodiment 3
[0026] Plumbago 2 kg, crushed into a 1mm raw material with a tissue grinder, put into a multifunctional extraction tank, add 4 times the amount of chloroform solution, soak at room temperature, extract for at least 12 hours, repeatedly extract 4 times, filter, and combine the filtrate After vacuum concentration and drying, apply the macroporous adsorption resin column AB-8, 1.5 times the column volume deionized water to elute impurities, and then use petroleum ether-acetone (10:1), petroleum ether-acetone (9:4), acetone -Methanol (1:2) was eluted with 3 times the column volume, collected the target eluate under the guidance of thin layer chromatography and recovered the solvent, concentrated and dried, added 75% ethanol and heated under reflux to saturate and dissolve, cooled, and slowly added deionized water, standing still for crystallization, and drying to obtain 6.4 g of the product with a content of 96%. Check with a silica gel plate, wherein the silica gel plate is made ...
PUM
Property | Measurement | Unit |
---|---|---|
melting point | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com