Preparation and application of chitosan particles

A technology of chitosan and microparticles, which is applied in the field of preparation of chitosan microparticles, and can solve problems such as poor results

Inactive Publication Date: 2011-02-23
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the animal model used in the 200910214313.6 patent application is a hyperlipidemia model rather than an obesity model, and according to the technical common sense in the art, there are significant differences in physiology and mechanism of action between the hyperlipidemia model and the obesity model, the present invention After a large number of long-term experiments, it is concluded that applying the existing technical solutions of chitosan in reducing blood lipids to the field of weight loss has little effect

Method used

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  • Preparation and application of chitosan particles
  • Preparation and application of chitosan particles
  • Preparation and application of chitosan particles

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Experimental program
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Effect test

Embodiment 1

[0032] The preparation of embodiment 1 chitosan microsphere

[0033] (1) Get 27.2g chitosan (made by existing methods or commercial products, molecular weight is 20~300,000, degree of deacetylation is 85~99%), add to 1800ml distilled water with mechanical stirrer, add 25ml volume The specific concentration is 36% acetic acid solution, stirred until the chitosan dissolves, and the chitosan solution is obtained for subsequent use;

[0034] (2) Use the domestic L-117 laboratory spray dryer (Beijing Laiheng Technology Trade Co., Ltd., and similar equipment from other manufacturers can also be used) to prepare micron particles. The preparation process uses a standard 0.7mm nozzle, and the drying tower enters the air The temperature is 160°C, the outlet temperature is 80-85°C, and the hot air flow rate is 90% (about 35m 3 / h), peristaltic pump flow 50% (about 600ml / h), compressed air pressure 120kPa.

[0035] The preparation method can also refer to the preparation scheme of the a...

Embodiment 2

[0037] The preparation of embodiment 2 chitosan microspheres

[0038] (1) get 28g chitosan (self-made according to existing method or commercially available product, molecular weight is 50,000, deacetylation degree is 60%) adds to 1800ml distilled water mechanical stirrer and stirs, and adding 25ml volume specific concentration is 36% Acetic acid solution is stirred until the chitosan is dissolved, and the chitosan solution is obtained for subsequent use;

[0039] (2) Use the domestic L-117 laboratory spray dryer (Beijing Laiheng Technology Trade Co., Ltd., and similar equipment from other manufacturers can also be used) to prepare micron particles. The preparation process uses a standard 0.7mm nozzle, and the drying tower enters the air The temperature is 190°C, the outlet temperature is 85-90°C, and the hot air flow rate is 90% (about 35m 3 / h), peristaltic pump flow rate 500ml / h, compressed air pressure 100kPa.

[0040] 16.5 g of chitosan microspheres were prepared with a ...

Embodiment 3

[0041] The preparation of embodiment 3 chitosan microspheres

[0042] Get 27.2g chitosan (self-made according to existing method or commercial product, molecular weight is 1,000,000, deacetylation degree is at 80%), other experimental methods are with embodiment 1.

[0043] 13.82g of chitosan microspheres were prepared with a yield of 54.2%. The particle size was measured using a laser particle size analyzer, and the average particle size was 7.87 μm.

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Abstract

The invention discloses a preparation method and application of chitosan particles. The chitosan particles comprise chitosan microspheres and chitosan nanoparticles. The invention provides the application of the chitosan particles in preparation of weight losing medicaments, fat lowering medicaments or foods; and by the conclusion of the researches, the chitosan microspheres have good effect in the application in the preparation of the medicaments or foods for suppressing appetite and the chitosan nanoparticles have good effect in the application in the preparation of the medicaments or foods for lowering the fat in the body. The invention provides technical support for applying the chitosan to the preparation of the medicaments or foods for losing weight better, and fulfilling the aims of effectively reducing dosage and achieving good weight losing effect.

Description

technical field [0001] The invention belongs to the technical field of medicine and functional food, and in particular relates to the preparation and application of chitosan particles. Background technique [0002] Chitosan, the only alkaline polysaccharide found so far in nature, has been proved by research that chitosan has obvious adsorption effect on fat, and has begun to be used in weight loss drugs. In developed countries such as Japan, Europe and the United States, chitosan weight loss drugs have developed rapidly and have become the mainstream trend of weight loss drugs. [0003] Chitosan (CTS) is obtained by deacetylation of chitin. It is a natural polycation polysaccharide derivative. It exists in large quantities in the shells of marine arthropods (shrimp, crab, etc.) In the cell membranes of species, insects, and algae, the resources are very rich. Chitosan itself has a positive charge so that it can combine with negatively charged fats and bile acids; chitosan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P3/04A61K31/722A61P3/06A23L1/29A61K9/14A61K9/16A23L33/00
Inventor 苏政权张宏亮陶毅高冰郭姣胡因铭龙斯韵
Owner GUANGDONG PHARMA UNIV
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