Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for detecting medicinal molecules by magnetic imprinting surface enhanced Raman spectroscopy technology

A surface-enhanced Raman, drug molecule technology, applied in Raman scattering, test sample preparation, material excitation analysis, etc., to achieve high extraction efficiency, simplified extraction and separation process, and simple separation.

Inactive Publication Date: 2011-04-13
JILIN UNIV
View PDF3 Cites 19 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot be used to directly analyze the molecules adsorbed on the molecularly imprinted separation medium, and a certain method must be used to separate the molecules adsorbed on the molecularly imprinted separation medium from the molecularly imprinted medium in order to carry out the follow-up of the molecule. analyze

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for detecting medicinal molecules by magnetic imprinting surface enhanced Raman spectroscopy technology
  • Method for detecting medicinal molecules by magnetic imprinting surface enhanced Raman spectroscopy technology
  • Method for detecting medicinal molecules by magnetic imprinting surface enhanced Raman spectroscopy technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Extraction, separation and SERS detection of ciprofloxacin in ciprofloxacin aqueous solution

[0024] 1) Dissolve 3.24 grams of hexahydrate, ferric chloride and 8.64 grams of anhydrous sodium acetate in 120 milliliters of ethylene glycol and stir. After the reactant is fully dissolved, put it into the reaction kettle, and carry out the hydrothermal synthesis reaction at 200 degrees Celsius for 8 hours. Then the kettle is taken out, and the prepared diameter of 200 nanometers of Fe is washed with 200 milliliters of absolute ethanol. 3 o 4 three times, and then to the washed Fe 3 o 4 Add 2 ml of oleic acid to mix, for Fe 3 o 4 The surface is modified, and after mixing for 10 minutes, use 50 ml of ethanol to remove excess oleic acid to obtain Fe modified by oleic acid. 3 o 4 Nanoparticles.

[0025] 2) The preparation of the pre-assembly solution of drug molecule and functional monomer is to dissolve 0.0736 g (0.2 mmol) of ciprofloxacin in 2 ml of deioniz...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a method for directly detecting medicinal molecules on a magnetic imprinting immobilized substrate by surface enhanced Raman spectroscopy technology. In the method, molecular imprinting technology is better combined with magnetic separation technology by using nano particles which comprise Fe3O4 serving as nuclear molecules and imprinted polymers serving as shells and have a nuclear shell structure so as to fulfill the aims of quickly and efficiently extracting and separating the medicinal molecules in a mixed system. In-situ and high-sensitivity detection can be directly performed on the medicinal molecules which are imprinted on the immobilized substrate of the molecule imprinted polymers by the surface enhanced Raman spectroscopy technology on the premise that the molecule imprinted polymers on which the medicinal molecules are imprinted are not processed to acquire related spectral information. By the method, the molecular imprinting technology, the magnetic separation technology and the surface enhanced Raman spectroscopy technology are combined. The invention provides the method which has the advantages of high extraction efficiency, simplicity in separation and high sensitivity for detecting the medicinal molecules.

Description

technical field [0001] The invention belongs to the technical field of drug molecule analysis and detection, and in particular relates to a method for directly detecting drug molecules on a magnetically imprinted immobilized substrate by using surface-enhanced Raman spectroscopy. Background technique [0002] Many drug molecules are widely used in clinical treatment and disease prevention due to their extensive antibacterial effects and important economic value. The emergence of antibiotics has played an important role in human disease prevention and treatment, but it has also brought human Certain hazards, such as residues of drug molecules in animal foods, or residues of drug molecules in plant foods. Therefore, the analysis and detection of trace drug molecules is of great significance. [0003] Molecularly imprinted technology is a technology for preparing polymers with specific recognition properties for specific molecules. Molecularly imprinted polymers have predeterm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65G01N1/28C08J9/26C08F222/14C08F212/36C08F2/44
Inventor 赵冰丁兰郭志男王旭阮伟东宋薇徐蔚青
Owner JILIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com