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A lactulose, high-purity technology is applied in the field of preparation of high-purity lactulose, and achieves the effects of reducing production costs, facilitating water-phase crystallization, and avoiding residual lactulitol
Active Publication Date: 2011-04-20
BAOLINGBAO BIOLOGY
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[0006] Aiming at the existing lactulose production conversion yield is not high, low-purity lactulose liquid crystallization is difficult, the final product purity is not high and other lactulose production problems, the present invention provides a A method for preparing high-purity lactulose that uses pure lactose as raw material to improve the conversion yield of lactulose and improve the purity of the final product
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Embodiment 1
[0031] (1) Weigh 10kg of high-purity lactose, add deionized water to prepare a lactose solution with a concentration of 15%, add 1.8kg of boric acid, stir, adjust the pH to 11.0 with 30% NaOH solution, and react at 80°C for 120 minutes to obtain a transformation solution. Quickly take out and cool down to 50°C;
[0032] (2) Pump the converted liquid after cooling into a chromatographic column equipped with Amberlite IR-120Na strong acidic cation exchange resin, with a column inner diameter of 250mm and a height of 1500mm. °C, the pH of the suspension sugar solution is controlled at 4.5;
[0033] (3) Decolorize the sugar solution after separation treatment, using Norit 1240Plus granular activated carbon, the inner diameter of the activated carbon column is 250mm, the height is 1500mm, the filling height of activated carbon is 1100mm, the temperature is 77°C, and the flow rate is controlled at 3BV;
[0034] (4) The decolorized sugar solution is pumped into an Amberlite IRA96C r...
Embodiment 2
[0038] (1) Weigh 10kg of high-purity lactose, add deionized water to prepare a lactose solution with a concentration of 20%, add 1.8kg of boric acid, stir, adjust the pH to 11.0 with 30% NaOH solution, and react at 80°C for 120 minutes to obtain a transformation solution. Quickly take out and cool down to 58°C;
[0039] (2) Pump the converted liquid after cooling into a chromatographic column equipped with Amberlite IR-120Na strong acidic cation exchange resin, with a column inner diameter of 250mm and a height of 1500mm. °C, the pH of the suspension sugar solution is controlled at 6.5;
[0040] (3) Decolorize the sugar solution after the separation treatment, using Norit 1240Plus granular activated carbon, the inner diameter of the activated carbon column is 250mm, the height is 1500mm, the filling height of the activated carbon is 1100mm, the decolorization temperature is 78°C, and the flow rate of the feed liquid is controlled at 2BV;
[0041] (4) The decolorized sugar sol...
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Abstract
The invention relates to the field of the preparation of functional sugar, and relates to a method for preparing high-purity lactulose. The method for preparing the high-purity lactulose comprises the following steps of: preparing lactose solution at the concentration of 15 to 20 percent; adding a boric acid and sodium hydroxide (NaOH) into the solution, and adjusting a reaction to obtain conversion liquid; performing ion exchange sodium ion (Na<+>)-removing treatment on the conversion liquid; decoloring a granular active carbon column; removing the boric acid from the lactose solution to obtain a lactose solution dry substance with the boric acid content of less than 1 mg / kg; concentrating the lactose solution until the concentration is 50 to 60 percent; separating by using a 10-bed continuous chromatographic separation device; and performing aqueous phase crystallization, wherein the cooling speeds are 0.8 DEG C per hour at the temperature of between 60 and 50 DEG C, 1 DEG C per hour at the temperature of between 50 and 30 DEG C and 1.1 DEG C per hour at the temperature of between 30 and 13 DEG C. The conversion rate of the lactulose can be increased, so that the yield of the lactulose products is greatly improved; granular active carbon is decolored; moving bed chromatographic separation is continuously simulated, so continuous chromatographic separation of the high-purity lactulose can be realized, the purity of the lactulose reaches over 92 percent so as to facilitate aqueous phase crystallization; and the purity can reach over 98 percent due to the aqueous phase crystallization.
Description
technical field [0001] The invention relates to the field of functional sugar preparation, in particular to a method for preparing high-purity lactulose. Background technique [0002] Lactulose, also known as lactulose, lactose, and galactosylfructoside, is a synthetic disaccharide formed by combining galactose and fructose with β-1,4 glycosidic bonds. The molecular formula is C12H22O11 and the molecular weight is 342. Lactulose has a good function of increasing the value of bifidobacteria, and has the effect of regulating the balance of intestinal microecology, and has a wide range of applications in medicine, food and animal feeding. It can reduce blood ammonia, catharsis, and treat constipation. It is also used for the prevention and treatment of various liver diseases. It can also be used as a low-calorie sweetener and functional food additive in food, and is widely used. [0003] Lactulose can be prepared by chemical method or biological method, among which the matu...
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