Heterogeneous layered mineralized coating on surface of medical implant and preparation method thereof

An implant and heterogeneous technology, applied in coatings, prostheses, medical science, etc., can solve problems such as less research on the distribution of coating components, and achieve the effect of easy promotion and simple operation

Inactive Publication Date: 2011-04-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] As far as the current research status is concerned, there are many studies on composite coatings, but there are fe

Method used

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  • Heterogeneous layered mineralized coating on surface of medical implant and preparation method thereof
  • Heterogeneous layered mineralized coating on surface of medical implant and preparation method thereof
  • Heterogeneous layered mineralized coating on surface of medical implant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Chitosan was dissolved in dilute hydrochloric acid to form a chitosan acid solution with a concentration of 1.25 g / L. Dissolve collagen in dilute hydrochloric acid to form a collagen acid solution with a concentration of 1.25 g / L. Ca(NO 3 ) 2 ·6H 2 O was dissolved in distilled water to form a calcium salt solution with a calcium concentration of 0.2M. Put (NH 4 ) 2 HPO 4 Dissolve in distilled water and stir to dissolve to form a phosphate solution with a phosphorus concentration of 0.2M. Chitosan acid solution and collagen acid solution are mixed according to the mass ratio of chitosan and collagen of 1:1, polyethylene glycol is added as a cross-linking agent, and the pH value of the solution is adjusted to 5.8 by dilute ammonia water to obtain A solution . The calcium salt solution and the phosphate salt solution are mixed according to the Ca / P molar ratio of 3:1 to obtain a B solution. Solution A and solution B were mixed according to a volume ratio of 10:1 t...

Embodiment 2

[0034] Chitosan was dissolved in dilute acetic acid to form a chitosan acid solution with a concentration of 2.5 g / L. Dissolve collagen in dilute acetic acid to form a collagen acid solution with a concentration of 2.5 g / L. CaCl 2 Dissolve in distilled water to form a calcium salt solution with a calcium concentration of 0.2M. Na 2 HPO 4 Dissolve in distilled water and stir to dissolve to form a phosphate solution with a phosphorus concentration of 0.2M. Chitosan acid solution and collagen acid solution were mixed according to the designed mass ratio of 1:1, the pH value of the solution was adjusted to 5.2 by dilute ammonia water, and glycerol was added as a cross-linking agent to obtain A solution. The calcium salt solution and the phosphate salt solution are mixed according to the molar ratio Ca:P=3:1 to obtain the B solution. Solution A and solution B were mixed according to 10:1 to obtain solution B. Mix solution B and chitosan acid solution at a ratio of 10:1 to obt...

Embodiment 3

[0036] Chitosan was dissolved in dilute nitric acid to form a chitosan acid solution with a concentration of 0.2 g / L. Dissolve collagen in dilute nitric acid to form a collagen acid solution with a concentration of 0.1 g / L. CaCl 2 ·6H 2 O was dissolved in distilled water to form a calcium salt solution with a calcium concentration of 1M. Dissolve phosphoric acid in distilled water and stir to dissolve to form a phosphate solution with a phosphorus concentration of 1M. Chitosan acid solution and collagen acid solution were mixed according to the designed mass ratio of 1:1, the pH value of the solution was adjusted to 4.8 by dilute ammonia water, and diisocyanate was added as a cross-linking agent to obtain A solution. The calcium salt solution and the phosphate salt solution are mixed according to the molar ratio Ca:P=3:1 to obtain the B solution. Solution A and solution B were mixed according to 10:1 to obtain solution B. Mix solution B and chitosan acid solution at a rat...

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Abstract

The invention discloses a heterogeneous layered mineralized coating on the surface of a medical implant. The surface of the medical implant is sequentially provided with a dense chitosan layer, a porous mineralized chitosan layer and a mineralized collagen/chitosan cross-linking layer from bottom to top. With Collagen, chitosan, a calcium-containing compound and a phosphorus-containing compound as raw materials, the heterogeneous layered mineralized coating is assembled once on the surface of a medical metal basal body through electrochemical reaction in a water solution, and the deposition state of each phase can be adjusted by adjusting the electrolytic deposition parameter, therefore, the heterogeneous layered mineralized coating is prepared. The method provided by the invention is simple and feasible and high in controllability; the medical material coating prepared with the method can promote the attachment and the propagation of cells on the surface of the coating and has a function of carrying drugs and enhanced bioactivity; and the bonding strength of the coating and a metal base plate is high, and the stability is favorable.

Description

technical field [0001] The invention relates to a heterogeneous layered mineralized coating on the surface of a medical implant and a preparation method thereof. Background technique [0002] For hard tissue implant materials, it should not only have mechanical properties, but also have the ability to bond with bone. Usually, a layer of calcium phosphate is coated on the surface of the metal substrate to meet the requirements of mechanical properties and biological properties. Calcium phosphate coating has good biocompatibility, osteoconductivity and biodegradability, however, calcium phosphate coating lacks the ability to directly interact with cells, and lacks drug-loading ability. Therefore, many studies have focused on the complexation of calcium phosphate with organic matter to improve the interaction with cells or drug molecules. For example, Chinese patent CN101244275 compounded chitosan and calcium phosphate to improve its drug-loading performance. Foreign patent R...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32A61L27/06C25D9/02C25D5/28
Inventor 翁文剑周加贝程逵宋晨路沈鸽杜丕一韩高荣
Owner ZHEJIANG UNIV
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