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G.japonicum mycelium polysaccharide refined substance freeze-dried powder injection and preparation method thereof

A technology of mycelium polysaccharides and freeze-dried powder injections, which is applied in the field of freeze-dried powder injections of refined polysaccharides from Zizhi mycelium and its preparation, achieving the effects of high polysaccharide content, reduced probability of adverse reactions, and low toxicity

Inactive Publication Date: 2014-06-04
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved by the present invention is to use the polysaccharide refined product of Zizhi anti-polysaccharide mycelium as raw material to provide a Zizhi mycelium with better anti-tumor activity, lower effective dose, less toxicity and lower incidence of adverse reactions Refined polysaccharide freeze-dried powder preparation

Method used

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  • G.japonicum mycelium polysaccharide refined substance freeze-dried powder injection and preparation method thereof
  • G.japonicum mycelium polysaccharide refined substance freeze-dried powder injection and preparation method thereof
  • G.japonicum mycelium polysaccharide refined substance freeze-dried powder injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] prescription composition

[0048]

[0049] Take the refined polysaccharide of Zizhi mycelia, dissolve it with an appropriate amount of water for injection, add mannitol and sodium citrate, stir for 20 minutes, add 0.8 mg of activated carbon for injection, heat at 80°C for 30 minutes, and filter it through a microporous membrane with a pore size of 0.22 μm after cooling Filter, pack in vials, 2mL per bottle, freeze-dry in a freeze-drying box, seal, and prepare injections. The pH of the obtained powder injection was 7.45.

Embodiment 2

[0051] prescription composition

[0052]

[0053] Take the refined polysaccharide of Zizhi mycelium, dissolve it with an appropriate amount of water for injection, add mannitol and sodium citrate, stir for 20 minutes, add 0.5% activated carbon for injection, heat at 80°C for 30 minutes, and filter it through a microporous membrane with a pore size of 0.22 μm after cooling Filter, pack in vials, 2mL per bottle, freeze-dry in a freeze-drying box, seal, and prepare injections. The pH of the obtained powder injection was 7.47.

Embodiment 3

[0055] prescription composition

[0056]

[0057] Take the refined polysaccharide of Zizhi mycelia, dissolve it with an appropriate amount of water for injection, add mannitol and sodium citrate, stir for 20 minutes, add 0.8 mg of activated carbon for injection, heat at 80°C for 30 minutes, and filter it through a microporous membrane with a pore size of 0.22 μm after cooling Filter, pack in vials, 2mL per bottle, freeze-dry in a freeze-drying box, seal, and prepare injections. The pH of the obtained powder injection was 7.46.

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Abstract

The invention discloses a G.japonicum mycelium polysaccharide refined freeze-dried powder injection, which is characterized by consisting of 5 to 25 weight percent of G.japonicum mycelium refined substance and 75 to 95 weight percent of freeze-dried excipient. The G.japonicum mycelium polysaccharide refined freeze-dried powder injection is prepared by the G.japonicum mycelium polysaccharide refined substance which contains more polysaccharide and has small molecular weight range, so that freeze-dried powder preparation has better tumor activity resistance, low response dosage and smaller toxicity; furthermore, the polysaccharide refined substance does not contain protein and other impurities, so, compared with the G.japonicum mycelium polysaccharide refined freeze-dried powder injection prepared by the prior art, the probability of causing adverse reaction by using the freeze-dried powder preparation is greatly reduced.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a freeze-dried powder injection of purified mycelium polysaccharide of Zizhi lucidum and a preparation method thereof. Background technique [0002] Edible and medicinal fungi have various functions such as anti-tumor and anti-virus, lowering blood lipids, delaying aging, protecting the liver and detoxifying, promoting nucleic acid and protein biosynthesis, etc., and have a long history of use in China. A large number of studies at home and abroad have shown that fungal polysaccharides are isolated from fungal fruiting bodies, mycelia, and fermentation broths. They are the active parts of fungal drugs, and they are a type of active polysaccharides that can control cell division and differentiation, and regulate cell growth and aging. . [0003] Zizhi (Ganoderma Sinense Zhao, Xu et Zhang) is a kind of Ganoderma lucidum. At present, there are few studies on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K31/715A61K36/074A61P35/00
Inventor 杨义芳金隽迪杨国红
Owner SHANGHAI INST OF PHARMA IND CO LTD
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