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Method for producing glucosamine and acetylglucosamine by using microwave technology

A technology of acetylglucosamine and glucosamine, applied in chemical instruments and methods, amino sugar, sugar derivatives, etc., can solve the problems of poor design, reduce production cost, low production capacity, etc., to increase production capacity and shorten reaction time , the effect of reduced overhead

Inactive Publication Date: 2011-05-04
YUAN ZE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] It can be known from the above-mentioned prior arts that the time required for the acidification hydrolysis reaction of the existing production of glucosamine or acetylglucosamine varies from tens of minutes to 24 hours; If the time is longer, the more man-hours will be required and the lower the production capacity will be, which will not be conducive to reducing production costs
[0019] It can be seen that the above-mentioned existing methods for producing glucosamine and acetylglucosamine still have many deficiencies, are not really good designs, and need to be improved urgently

Method used

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  • Method for producing glucosamine and acetylglucosamine by using microwave technology
  • Method for producing glucosamine and acetylglucosamine by using microwave technology
  • Method for producing glucosamine and acetylglucosamine by using microwave technology

Examples

Experimental program
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Embodiment 1

[0038] The preparation of embodiment 1 chitin or chitosan source

[0039] In this example, a large number of fungi that produce chitin or chitosan are cultivated in a shaking flask fermentation culture method, and these fungi are used as the source of chitin or chitosan, and then the fungal cells are broken and the chitin is taken out quality or chitosan, and finally hydrolyzed with hydrochloric acid to obtain glucosamine or acetylglucosamine products.

[0040] 1.1 Test strains

[0041] In this example, Aspergillus sp. BCRC31742 was used as a strain for producing fungal biomass, which was purchased from the Institute of Food Industry Development (Taiwan, Hsinchu).

[0042] 1.2 Shake flask fermentation culture

Embodiment 2

[0044] Embodiment 2 Hydrochloric acid hydrolysis reaction test

[0045] Hydrochloric acid hydrolysis reaction test flow is as follows: figure 1 As shown, the fungal biomass prepared in Example 1 is used as a source of chitin or chitosan, after adding hydrochloric acid, under different reaction conditions, hydrolysis is carried out to obtain glucosamine or acetylglucosamine products, and Add 1-naphthyl isothiocyanate pyridine (1-NITC) solution for derivatization reaction, and then use high performance liquid chromatography (High Performance Liquid Chromatography, HPLC) to determine the content of glucosamine.

[0046] 2.1 Using a traditional oven as a heat source test

[0047] For each sample, 10ml of fungal cell homogeneous solution was used as the test material, and 10ml of 2N, 4N, 6N hydrochloric acid (HCl) solutions of different concentrations were added, mixed and placed in a conventional oven at 100°C for heating reactions 1, 2, 3, and 4 respectively. , 6, 8, 12, 16, 20...

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Abstract

The invention discloses a method for producing glucosamine and acetylglucosamine by using microwave technology, which comprises the following steps of: (1) providing a chitin or chitosan source; (2) adding acid solution into the chitin or chitosan source to form reaction solution; and (3) putting the reaction solution into a microwave device to perform hydrolysis reaction, namely hydrolyzing the chitin or the chitosan to generate the glucosamine or the acetylglucosamine. By using a microwave oven for hydrochloride reaction, the method can effectively shorten the reaction time, achieve the same effect as the traditional method by only about 3 to 10 minutes, greatly shorten the process time, increase the capacity and reduce the production cost of the glucosamine or the acetylglucosamine.

Description

technical field [0001] The invention relates to a method for producing glucosamine and acetylglucosamine, in particular to a method for producing glucosamine and acetylglucosamine by hydrolyzing chitin or chitosan by using a microwave device as a heat source for hydrolysis reaction. Background technique [0002] Glucosamine (GlcN), or 2-amino-2-deoxy-D-glucose (2-amino-2-deoxy-D-Glucose), is one of the components of articular cartilage, which can provide nutrition for joint tissue, Increase the synovial fluid to restore the lubrication function, promote the regeneration of degenerated joints, and then effectively relieve the pain caused by bone friction and prevent the deterioration of arthritis symptoms. The human body can synthesize glucosamine by itself, but with age, the speed of glucosamine synthesis in the human body is not as fast as the speed of decomposing glucosamine, so it is prone to lack of glucosamine in the body and joints, and affects the metabolism of cells ...

Claims

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Application Information

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IPC IPC(8): C07H1/00C07H5/06
Inventor 吴和生林柏丞艾利·柏英·斯唐刚
Owner YUAN ZE UNIV