Traditional Chinese medicine preparation for treating liver cancer

A traditional Chinese medicine preparation, a technology for treating liver cancer, which can be used in medical preparations containing active ingredients, pill delivery, antitumor drugs, etc., and can solve problems such as low selectivity, multidrug resistance, and induction of secondary tumors.

Active Publication Date: 2011-06-01
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in addition to surgical resection, Western medicine mainly uses interventional therapy and chemotherapy in the treatment of liver cancer. However, even with radical resection, there is still a recurrence rate of 60% to 70% within 5 years; , Hepatic function limitation of cirrhosis and other reasons make about 30% of patients with liver cancer who can be surgic

Method used

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  • Traditional Chinese medicine preparation for treating liver cancer
  • Traditional Chinese medicine preparation for treating liver cancer
  • Traditional Chinese medicine preparation for treating liver cancer

Examples

Experimental program
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Effect test

example 1

[0021] 1. Prescription:

[0022] 2160g of Phyllostachys foliage, 1440g of Sophora flavescens, 1080g of Xihuangcao, 288g of Panax notoginseng, 360g of Salvia miltiorrhiza, 360g of peach kernel, 360g of Bupleurum bupleurum, 360g of Ligustrum lucidum, 360g of licorice, 288g of heterophylla, 144g of licorice.

[0023] 2. Preparation method:

[0024] (1) Weighing the crude drug and cutting into sections according to the prescription, pulverizing, adding 12 times of 60% ethanol, homogenizing, centrifuging to obtain centrifugate and centrifuge slag;

[0025] (2) the centrifugate obtained in step (1) is successively ultrafiltered through a ceramic membrane filter element and a 10Kda filter element, and then concentrated by reverse osmosis to a concentration ratio of 1: 1 (equivalent to containing 1kg of raw material drug in every liter of concentrated solution), Reclaiming ethanol again and concentrating in vacuo into a concentrated extract with a concentration ratio of 2: 1 (equival...

example 2

[0032] 1. Prescription:

[0033] Phyllostachys 900g, Xihuangcao 900g, Sophora flavescens 748.8g, Panax notoginseng 302.4g, Salvia miltiorrhiza 900g, peach kernel 302.4g, Bupleurum 302.4g, Ligustrum lucidum 900g, Eclipta 900g, Pseudostellaria 900g, licorice 144g.

[0034] 2. Preparation method:

[0035] (1) Weighing the crude drug and cutting into sections according to the prescription, pulverizing, adding 8 times of 60% ethanol, homogenizing, centrifuging to obtain centrifugate and centrifuge residue;

[0036] (2) the centrifugate obtained in step (1) is successively ultrafiltered through a ceramic membrane filter element and a 10Kda filter element, and then concentrated by reverse osmosis to a concentration ratio of 1: 1 (equivalent to containing 1kg of raw material drug in every liter of concentrated solution), Reclaim ethanol again and vacuum concentrate into the extractum that concentration ratio is 1.6: 1 (being equivalent to containing 1.6kg bulk drug in every liter of ...

example 3

[0043] 1. Prescription:

[0044] Phyllostachys 360g, Sophora flavescens 360g, Xihuangcao 360g, Panax notoginseng 576g, Salvia miltiorrhiza 1440g, Peach kernel 720g, Bupleurum 720g, Ligustrum lucidum 720g, Lilycystis chinensis 720g, Pseudostellaria 1080g, Licorice 144g.

[0045] (1) Weighing the crude drug and cutting into sections according to the prescription, pulverizing, adding 10 times of 60% ethanol, homogenizing, centrifuging to obtain centrifugate and centrifuge slag;

[0046] (2) the centrifugate obtained in step (1) is successively ultrafiltered through a ceramic membrane filter element and a 10Kda filter element, and then concentrated by reverse osmosis to a concentration ratio of 1: 1 (equivalent to containing 1kg of raw material drug in every liter of concentrated solution), Reclaim ethanol again and vacuum concentrate into the extractum that concentration ratio is 1.6: 1 (being equivalent to containing 1.6kg bulk drug in every liter of extractum);

[0047] (3) Mi...

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Abstract

The invention relates to a medical configuration item, in particular to a traditional Chinese medicine preparation for treating liver cancer. The preparation is composed of an effective ingredient and medically acceptable excipients, wherein the effective ingredient is prepared by the following bulk drugs on a mass basis: 5-30% of underleaf pearl, 5-20% of sophora flavescens, 5-30% of rabdosia serra, 4-10% of panax notoginseng, 5-25% of salvia, 4-15% of peach kernel, 4-10% of bupleurum, 5-25% of ligustrum lucidum, 5-25% of yerbadetajo herb, 2-25% of radix pseudostell, and 2-10% of licorice. By combining above 11 drugs, the preparation has heat-clearing and detoxifying, blood-activiating and stasis-dissolving, liver-soothing and depression-resolving, spleen-invigorating and kidney-tonifying efficacy, and furthermore the preparation can inhibit the growth of tumors and achieve the purpose of treating liver cancers.

Description

technical field [0001] The invention relates to medical preparations, in particular to Chinese patent medicines with plants as raw materials. Background technique [0002] Primary liver cancer (PLC, referred to as liver cancer) is one of the most common malignant tumors in clinical practice. It ranks third in cancer-related deaths. my country is a country with a high incidence of liver cancer. Every year, 306,000 people develop the disease, accounting for about 55% of the world's new cases, and about 300,000 people die of liver cancer every year. It is a major disease that seriously threatens the health and life of our people. [0003] The pathogenesis of liver cancer is the result of multiple factors, multiple steps, and multiple gene mutations. The cause of the disease is closely related to post-hepatitis cirrhosis caused by hepatitis B virus (HBV) infection or hepatitis C virus (HCV) infection, and alcoholic cirrhosis caused by long-term alcoholism. [0004] At present...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/16A61K9/20A61K9/48A61P1/16A61P35/00
Inventor 李常青宋力飞
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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