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Polyvinyl alcohol-based medical sponge and preparation method thereof

A polyvinyl alcohol and sponge technology, used in medical science, bandages, prostheses, etc., can solve the problems of low pore connectivity, difficult to control pore size, and carbonate foaming too fast, and achieve porosity and resilience. Effectively controllable, uniform pore size distribution, and guaranteed stability

Inactive Publication Date: 2011-06-01
郑绮霞 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

U.S. Patent No. 4,098,728 discloses a medical PVF sponge that is prepared by mechanically stirring air alone. The size of the pores is controlled by the amount of surfactant and the stirring speed. Although the purity of the sponge is high, the connectivity of the pores is not high, and the density and resistance Low pressure elasticity, severe molding shrinkage, difficult to control pore size
Chinese patent CN94102999.9 discloses a medical PVF sponge prepared by mechanical foaming combined with carbonate chemical foaming. The carbonate decomposes into carbon dioxide when it encounters acid, which greatly improves the connectivity of the pores, but the carbonate is in the process of adding acid. Foaming rapidly before the post-crosslinking reaction, molding shrinkage is still serious, and the pore size is difficult to control
Chinese patent application CN200910060414.2 discloses a sodium alginate and polyvinyl alcohol composite medical sponge that uses carbonate chemical foaming alone. Shrinkage severe defect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Dissolve 4 grams of dinitrosopentamethylenetetramine in 6 grams of dimethylformamide to make a blowing agent solution, and dissolve 15 grams of polyvinyl alcohol in 61 grams of hot water to make polyethylene Alcoholic solution. Add the polyvinyl alcohol solution into the reactor and heat it to 70°C, add 8 grams of 37% formaldehyde solution, 10 grams of foaming agent solution and 6 grams of 50 wt% sulfuric acid solution to obtain the mixture to be foamed. Pour the mixture to be foamed into a mold, foam at 80°C, solidify and form, and obtain a sponge material. Remove the sponge material from the mold, first wash repeatedly with pure water, then repeatedly wash with dimethylformamide, and finally wash off the solvent with pure water. The sponge material was dried at 60°C to obtain a polyvinyl alcohol-based medical sponge. A polyvinyl alcohol based medical sponge is obtained. The performance test results of the sponge are that the wet compressive elastic modulus is 50.4k...

Embodiment 2

[0014] Dissolve 3 grams of dinitrosoterephthalamide in 5 grams of acetone to form a blowing agent solution, and dissolve 12 grams of polyvinyl alcohol in 65 grams of hot water to form a polyvinyl alcohol solution. Add the polyvinyl alcohol solution into the reaction kettle and heat it to 60°C, add 7 grams of 40% acetaldehyde solution, 8 grams of foaming agent solution and 8 grams of 35 wt% hydrochloric acid solution to obtain the mixture to be foamed. The mixture to be foamed is poured into a mold to be foamed at 70° C., solidified and molded to obtain a sponge material. Remove the sponge material from the mold, first wash repeatedly with pure water, then repeatedly wash with acetone, and finally wash off the solvent with pure water. The sponge material was dried at 70°C to obtain a polyvinyl alcohol-based medical sponge. The performance test results of the sponge are that the wet compressive elastic modulus is 40.0kPa, and the apparent density is 0.080g / cm 3 , the porosity ...

Embodiment 3

[0016] Dissolve 2.5 grams of nitroso trimethylene tritetramine in 7.5 grams of dimethylformamide to make a blowing agent solution, and dissolve 13 grams of polyvinyl alcohol in 65 grams of hot water to make polyvinyl alcohol solution. Add the polyvinyl alcohol solution into the reaction kettle and heat it to 65°C, add 5 grams of 50% glutaraldehyde solution, 10 grams of foaming agent solution and 7 grams of 35 wt% sulfuric acid solution to obtain the mixture to be foamed. Pour the mixture to be foamed into a mold, foam at 75°C, solidify and form, and obtain a sponge material. Remove the sponge material from the mold, first wash repeatedly with pure water, then repeatedly wash with dimethylformamide, and finally wash off the solvent with pure water. The sponge material was dried at 65°C to obtain a polyvinyl alcohol-based medical sponge. The performance test result of the sponge is that the wet compressive elastic modulus is 60.0kPa, and the apparent density is 0.110g / cm 3 , ...

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Abstract

The invention relates to a medical sponge material using acetalized polyvinyl alcohol as a main base material. The invention is characterized in that the medical sponge material has continuous open porous structures, the wet compressive modulus of elasticity is 40-70kPa, the apparent density is 0.08-0.12g / cm<3>, and the porosity is 80-95%. The invention also relates to a preparation method of the sponge, which is characterized by comprising the following steps: selecting a chemical foaming agent capable of slowly releasing gas while being heated in water, and dissolving the foaming agent in a solvent which is miscible with water before admixing with other foaming materials; and after hot forming, treating the obtained sponge material by the conventional water washing method, and further washing with a solvent. The sponge provided by the invention has the advantages of small impurity residual quantity, low forming shrinkage rate and large wet compression elasticity, pores are highly communicated with each other, and the pore diameter is uniform and easy to control. Thus, the sponge can be used in the surgical medicine field, and is especially suitable to be used as a consumable sponge material for vacuum sealing drainage.

Description

technical field [0001] The invention relates to a medical sponge and a preparation method thereof, more specifically, the present invention relates to a polyvinyl alcohol-based medical sponge with high compressive elastic modulus, porosity and pore connectivity and a preparation method thereof, belonging to field of medical materials. Background technique [0002] Acetalized polyvinyl alcohol sponge (PVF sponge) has good water absorption, mechanical properties and biocompatibility, and has been widely used in the field of surgical medicine, such as blood-absorbing materials for surgery, wound protection materials, instrument wiping materials, surgical plastic packing materials and nasal packing compression hemostatic materials, etc. In recent years, PVF sponge has also been used as an interface material in contact with the wound surface in negative pressure sealing drainage therapy, which plays the role of transmitting negative pressure and leading away secretions. Compare...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/42A61L27/16A61L27/56A61L31/04A61L31/14C08L29/14C08J9/10
Inventor 郑绮霞许高琴
Owner 郑绮霞
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