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Preparating method for glucosamine hydrochloride from chitin

A technology of glucosamine hydrochloride and chitin, which is applied in the field of process improvement of medical intermediates, can solve problems such as pollution and low yield, and achieve the effects of reduced emissions, reduced processing time, and reduced maintenance costs

Active Publication Date: 2015-01-21
林大昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the technical defects of low yield and serious pollution in the above-mentioned ammonia sugar production process, the object of the present invention is to provide a method for preparing glucosamine hydrochloride from chitin, which improves the ammonia sugar yield, saves energy, and reduces sewage discharge

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The method for preparing glucosamine hydrochloride from chitin, the method comprises the following steps:

[0021] (1) With 30m 2 Add 1200kg of 36% hydrochloric acid to the 3000L enamel reaction kettle of the straight pipe reflux device, add 300kg of waste mother liquor, the concentration of hydrochloric acid of waste mother liquor is 28%, heat to 60°C, start the stirring device, the speed is 45r / min, and use polytetrafluoroethylene Add the chitin (ash content 8.4%, moisture 9.2%) 1000kg after crushing and sieving to the propeller;

[0022] (2) After dissolving, the temperature is raised to 82°C, the stirring speed is 25r / min, and the temperature is kept at 83°C. After 15 minutes, 36% hydrochloric acid is added dropwise, the flow rate is 8.5L / min, the amount of hydrochloric acid is 500L, and the heat preservation is continued at 83°C after 60 minutes;

[0023] (3) After 30 minutes, use cooling water to cool down to 40 ° C, discharge the material, and vacuum filter the ...

Embodiment 2

[0025] Concentrate the first mother liquor after suction filtration in Example 1, recover hydrochloric acid, combine the concentrated four to five slags together, add 36% hydrochloric acid dropwise to make the concentration of the slurry 32% to 34%, and heat up to 82°C , hydrolyzed for 1.5h, discharged after cooling, temperature<40°C, precipitated for 8h, and filtered to obtain the crude material B, which was mixed with the crude material A obtained in Example 1 for dissolution, decolorization, concentration, washing, recrystallization, Drying becomes finished product.

[0026] Secondary mother liquor 1725kg in the above-mentioned technology, concentration reclaims hydrochloric acid 1380kg, reclaims hydrochloric acid concentration and is 28.7%, and slurry is repeated once by above-mentioned technology, and fine product yield is 4.45%, and total yield is 68%.

[0027] The technical effect that the present invention compares with prior art is shown in the table below

[0028] ...

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PUM

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Abstract

The invention belongs to the technology field of technology improved medical intermediate. A preparing method for glucosamine hydrochloride by chitin comprises the following steps: (1) crushing: crushing the chitin raw materials; (2) dissolving: adding 30% to 35% hydrochloric acid in a reaction vessel, heating to 50 to 65 DEG C, starting stirring, adding the chitin raw materials and dissolving; (3)hydrolysis: heating to 80 to 85 DEG C, keeping the temperature for 5 to 20 minutes, then starting to add hydrochloric acid at a concentration of 34% to 36%, keeping the concentration of the hydrochloric acid in the reaction system greater than 30%, continuing to keep the reaction system at a temperature of 80 to 85 DEG C, prolonging 5 to 30 minutes till the reaction ends, feeding after cooling, depositing below 40 DEG C and vacuum filtering to obtain crude material A; (4)extraction: extracting and drying crude material A to obtain a finished product. The technology of the invention can reduce carbonization rate by more than 10%, increase yield to 65% to 75%, reduce the consumption amount of the hydrochloric acid descends by more than 50%, reduce discharge capacity of waste mother liquor by more than 60% and reduce processing technology time by more than 60%.

Description

technical field [0001] The invention belongs to the technical field of technical improvement of medical intermediates, and in particular relates to a method using a new acid hydrolysis process in the process of preparing glucosamine hydrochloride from chitin. Background technique [0002] Glucosamine hydrochloride, referred to as glucosamine for short, is an intermediate in the medical industry and an end product. It has important physiological functions to the human body, participates in liver and kidney detoxification, exerts anti-inflammatory and liver-protecting effects, stimulates the growth of mycobacteria in the intestinal tract, has specific curative effects on the treatment of arthritis and gastric ulcer, can inhibit the growth of cells, and is a synthetic anti-cancer The main raw material of medicine. At the same time, it is also widely used in food, cosmetics and feed additives. The global demand is increasing, and the domestic export volume has reached more tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H5/06C07H1/08
Inventor 林大昌
Owner 林大昌