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Externally applied antithyroid gel and preparation method thereof
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An anti-thyroid and gel technology, which is applied in the field of medicine, can solve the problems of heating, traces, and limited application range, etc., and achieve the effects of large cumulative drug penetration, slowing down peak and valley fluctuations, and reducing adverse reactions
Inactive Publication Date: 2011-06-15
张蔚
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Summary
Abstract
Description
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Problems solved by technology
A class is emulsifiable cream or ointment, such as CN1084078A, CN1085079A and CN1692940A, the defective of disclosed preparation is: (1) wherein has added glucocorticoid, easily produces a lot of serious side effects for human body, such as digestive tract, cardiovascular complication, Neuropsychiatric abnormalities, osteoporosis, dermatitis, etc., limit its scope of use, and are not conducive to long-term medication; (2) these creams and ointments have many problems in production practice, and cannot be industrialized on a large scale: due to drugs and some The matrix needs to be heated and the temperature is too high. If it is left for too long, it will easily cause the separation of the drug and the matrix, which will affect the stability of the drug and reduce the use effect of the patient.
(3) Due to the presence of matrix particles in these creams and ointments, when patients use them, it is difficult to grasp the control of the therapeutic dose
Patches have the same disadvantages as ointments or creams: the application site is on the neck, and they will be on the exposed part of the person after application or even after the drug has penetrated - there are obvious marks or residues on the neck
Many people will choose to use intermittently from time to time, which will affect the treatment of diseases
Method used
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Embodiment 1
[0024]
[0025] making process:
[0026] 1. Wet 1g of carbomer with a small amount of solvent, and then gradually add solvent to grind to make it fully swell;
[0028] 3. Take 5g of propylene glycol and 10g of glycerin and mix until uniform;
[0029] 4. Add 0.5g of methimazole into an appropriate amount of pure water, add 0.5g of PEG-400 and stir to dissolve; add propylene glycol glycerin mixture, 0.1g of cysteine, and 0.1g of ethylparaben, stir well, add water to volume, Stir well to make a mixture;
[0030] 5. Slowly add the mixed liquid (3) into the carbomer gel matrix, grind until uniform, and the product is ready.
Embodiment 2
[0032]
[0033] making process:
[0034] 1. Sprinkle 1g of Carbomer on the liquid surface of about 50ml of pure water (below 40°C) and leave it overnight to make it fully swell and avoid agglomeration;
[0035] 2. Slowly add 1g of triethanolamine dropwise and grind until uniform;
[0036] 3. Add 1.0 g of methimazole into an appropriate amount of pure water and stir to dissolve. Then add 8g of propylene glycol, 10g of glycerin, and 0.1g of ethylparaben one by one, stir evenly, add water to volume, stir evenly, and make a mixed solution;
[0037] 4. Slowly add the mixed solution (3) into the carbomer gel matrix, grind until uniform, and the product is ready.
Embodiment 3
[0039]
[0040] making process:
[0041] 1. Sprinkle 1g of carbomer on the surface of 10g of glycerin, grind evenly until completely mixed. Add 20-30ml of water and grind until fine, then add 30-40ml of water and let stand to fully swell the carbomer to make a mixed solution 1;
[0042] 2. Slowly add 1g of triethanolamine dropwise and grind until uniform;
[0043] 3. Add 2.0 g of methimazole into an appropriate amount of pure water, and stir to dissolve. Then add 10 g of propylene glycol and 0.1 g of ethylparaben one by one, stir evenly, add water to volume, stir evenly, and make a mixed solution;
[0044] 4. Slowly add the mixed solution (3) into the mixed solution 1, and grind until it is uniform.
[0045] Identify the product of embodiment 1-3: be uniform, fine and smooth colorless transparent methimazole gel.
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Abstract
The invention provides an externally applied antithyroid gel. The externally applied antithyroid gel comprises a medicament, a macromolecular substrate material, a solvent, a cosolvent, a humectant and a preservative, and selectively contains any of an antioxidant, a neutralizer and a penetration enhancer. Defects of the traditional curative medicament are overcome by the externally applied antithyroid gel. When smeared on a neck lesion site, the antithyroid gel has high absorption effect, obvious treatment effect and no obvious side effect for the whole body, and is suitable for mass production. Particularly, no trace or residue is left on the smeared part after the antithyroid gel is smeared or absorbed. When the antithyroid gel is used for treating hyperthyroidism, the repeated incidence and the relapse rate are low, the treatment effect on hyperthyroidism is improved, and pains of patients are alleviated.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to an antithyroid gel for external application and a preparation method thereof. Background technique [0002] Hyperthyroidism is a syndrome caused by excessive secretion of thyroidhormone. It is characterized by goiter, increased basal metabolism and abnormalities of the autonomic nervous system. Hyperthyroidism is a frequently-occurring and common disease, and most patients are women. The systemic adverse reactions of oral antithyroid drugs in clinical treatment mainly include: ① Leukopenia and neutropenia, the incidence rate is about 10%, and agranulocytosis may occur in severe cases. Mainly occurs 2 to 3 months after the start of treatment; ② skinrash, the incidence rate is about 2 to 3%; ③ cholestatic jaundice, toxic hepatitis, etc. E. Oral medication also has the disadvantages of slow curative effect and low remission rate after drug withdrawal in the course of treatment...
Claims
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Application Information
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