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After-treatment method for synthesizing neohesperidin dihydrochalcone from neohesperidin

A technology of hesperidin dihydrochalcone and neohesperidin, which is applied in the post-processing field of neohesperidin synthesis of neohesperidin dihydrochalcone, can solve the problems of low yield and achieve sample recovery The effect of high efficiency, reduced operation steps, and reduced production costs

Inactive Publication Date: 2011-06-15
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] The present invention mainly aims at the deficiencies of the prior art, provides a post-treatment method for synthesizing neohesperidin dihydrochalcone from neohesperidin, solves the problem of low yield in the prior art, and fills the gap between the use of resin or polyamide Technical gaps in post-treatment of neohesperidin and synthetic sweetener NHDC

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Put 50.0g of neohesperidin in the reaction kettle, add 500mL of purified water, sodium hydroxide, stir to dissolve, then add the catalyst palladium carbon, seal the reaction kettle, replace the air in the reaction kettle with nitrogen, and then pass in hydrogen at room temperature Nitrogen was replaced, a certain stirring speed was set, and samples were taken after different reaction times. After the reaction, the hydrogen in the reactor was replaced with nitrogen, then the reaction was stopped, and the reaction solution was taken out.

[0024] Adjust the pH value of the reaction solution to 5-6, crystallize at normal temperature for 8h, filter to obtain 40.3g of crystal I; Purified water was eluted to remove the salt in the reaction. Then eluted with 10 times column volume of 20% ethanol, and then eluted with 30% ethanol to obtain a sample, collected and concentrated the sample solution, and crystallized to obtain 5.22 g of crystal II. The total yield calculated by c...

Embodiment 2

[0026] Put 50.0g of neohesperidin in the reaction kettle, add 500mL of purified water, sodium hydroxide, stir to dissolve, then add the catalyst palladium carbon, seal the reaction kettle, replace the air in the reaction kettle with nitrogen, and then pass in hydrogen at room temperature Nitrogen was replaced, a certain stirring speed was set, and samples were taken after different reaction times. After the reaction, the hydrogen in the reactor was replaced with nitrogen, then the reaction was stopped, and the reaction solution was taken out.

[0027] Adjust the pH value of the reaction solution to 5-6, crystallize at room temperature for 8 hours, and filter to obtain 38.5 g of crystal I; the mother liquor is adsorbed with polyamide, and after the sample is adsorbed, it is first eluted with purified water to remove the salt in the reaction. Then eluted with 10 times column volume of 20% ethanol, and then eluted with 50% ethanol to obtain a sample, and the sample solution was c...

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Abstract

The invention discloses an after-treatment method for synthesizing neohesperidin dihydrochalcone from neohesperidin, which comprises the following steps: (1) carrying out catalytic hydrogenation on neohesperidin under the action of palladium on carbon, filtering, regulating the pH value of the filtrate to 3-6, and crystallizing at normal temperature to obtain a crystal 1; (2) filtering, and adsorbing the sample in the mother liquid; (3) after adsorbing the sample, eluting the sample with purified water to remove salts in the reaction liquid; (4) eluting with 1-30% ethanol to remove impurities in the mother liquid after crystallization; (5) eluting the sample with 30-100% ethanol, and collecting the sample liquid; and (6) concentrating, and carrying out secondary crystallization. The invention solves the problem of low yield in the prior art, and fills up the blank in the technology of after-treatment of neohesperidin and synthetic sweetening agent NHDC (neohesperidin dihydrochalcone) by using resin or polyamide.

Description

technical field [0001] The invention belongs to the post-treatment technology of sweetener production and preparation process, and in particular relates to a post-treatment method for synthesizing neohesperidin dihydrochalcone from neohesperidin. Background technique [0002] Neohesperidin dihydrochalcone (NHDC) is a new sweetener obtained by hydrogenation of neohesperidin extracted from natural citrus plants, with high sweetness (1500-1800 times the sweetness of sucrose ), low calorie, and non-toxic. At present, neohesperidin dihydrochalcone has been approved by many countries as a spice or sweetener, and is widely used in food industry, pharmaceutical industry and feed industry. [0003] At present, the reaction solution for synthesizing NHDC is crystallized by traditional methods, and the yield is less than 90%. Contents of the invention [0004] The present invention mainly aims at the deficiencies of the prior art, provides a post-treatment method for synthesizing n...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/06
Inventor 袁小红徐国波侯大斌徐春霞冯运波袁其朋张国林
Owner SOUTHWEAT UNIV OF SCI & TECH
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