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Composition preparation of lomefloxacin compound and sodium chloride and preparation method thereof

A technology of lomefloxacin and sodium chloride, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of reduction of active ingredients, poor stability, etc. , good solubility, reducing the effect of catalytic oxidation by metal ions

Inactive Publication Date: 2011-08-03
广东好药多医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition injection of lomefloxacin compound and sodium chloride is a large infusion solution, which will inevitably come into contact with metals during the preparation and filling process, and this type of drug is sensitive to metal ions and can be catalyzed and oxidized by metal ions, not only The active ingredients are reduced, and the stability of the product is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The embodiment of the present invention a kind of preparation method of the composition preparation of lomefloxacin compound and sodium chloride, consists of the following steps:

[0015] (1) Take 300ml of water for injection and place it in a container, then add 9g of sodium chloride, 200mg of glutamic acid, 20mg of disodium edetate, and 300mg of citric acid, dissolve and add activated carbon to filter to form a solution A;

[0016] (2) Take 40ml of water for injection and put it in another container, add 2g of lomefloxacin sodium chloride, and stir until it is completely dissolved to form solution B;

[0017] (3) Add solution B to solution A, add water for injection to the full amount, add activated carbon again, filter after stirring, control the pH value at 5.5, and form solution C;

[0018] (4) Detect the contents of lomefloxacin and sodium chloride in solution C, and the qualified solution can be packaged after fine filtration, potting, and sterilization to form ...

Embodiment 2

[0020] The embodiment of the present invention a kind of preparation method of the composition preparation of lomefloxacin compound and sodium chloride, consists of the following steps:

[0021] (1) Take 400ml of water for injection and place it in a container, then add 9g of sodium chloride, 150mg of glutamic acid, 50mg of disodium edetate, and 100mg of citric acid, dissolve and add activated carbon to filter to form a solution A;

[0022] (2) Take 60 ml of water for injection and place it in another container, add 2 g of lomefloxacin sodium chloride, stir until it is completely dissolved, and form solution B;

[0023] (3) Add solution B to solution A, add water for injection to the full amount, add activated carbon again, filter after stirring, control the pH value at 5, and form solution C;

[0024] (4) Detect the contents of lomefloxacin and sodium chloride in solution C, and the qualified solution can be packaged after fine filtration, potting, and sterilization to form ...

Embodiment 3

[0026] The embodiment of the present invention a kind of preparation method of the composition preparation of lomefloxacin compound and sodium chloride, consists of the following steps:

[0027] (1) Take 350ml of water for injection and put it in a container, then add 9g of sodium chloride, 100mg of glutamic acid, 30mg of disodium edetate, and 150mg of citric acid, dissolve and add activated carbon to filter to form a solution A;

[0028] (2) Take 50 ml of water for injection and place it in another container, add 2 g of lomefloxacin sodium chloride, stir until it is completely dissolved, and form solution B;

[0029] (3) Add solution B to solution A, add water for injection to the full amount, add activated carbon again, stir and filter, and control the pH value at 4 to form solution C;

[0030] (4) Detect the contents of lomefloxacin and sodium chloride in solution C, and the qualified solution can be packaged after fine filtration, potting, and sterilization to form a fini...

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PUM

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Abstract

The invention discloses a composition preparation of a lomefloxacin compound and sodium chloride. The composition preparation is injection, wherein the injection is prepared from lomefloxacin, sodium chloride, glutamic acid, disodium edentate, citric acid and water for injection, and each 100 milliliters of injection contains 200 milligrams of lomefloxacin, 900 milligrams of sodium chloride, 5 to 20 milligrams of glutamic acid, 2 to 5 milligrams of disodium edentate, 10 to 30 milligrams of citric acid and the balance of water for injection. The composition preparation of the lomefloxacin compound and the sodium chloride has high stability. The invention also provides a preparation method for the composition preparation of the lomefloxacin compound and the sodium chloride.

Description

technical field [0001] The invention relates to a composition preparation of a lomefloxacin compound and sodium chloride, in particular to a composition injection of a lomefloxacin compound and sodium chloride and a preparation method thereof. Background technique [0002] Lomefloxacin is a third-generation quinolone antibacterial agent, which has the advantages of broad antibacterial spectrum, strong antibacterial activity, long half-life, and few side effects. It is widely used in the treatment of respiratory tract, genitourinary tract, biliary tract, intestinal tract, skin and soft tissue infection, otitis media and sinusitis caused by sensitive bacteria. Lomefloxacin has high antibacterial activity against Enterobacteriaceae bacteria such as Escherichia coli, Shigella, Klebsiella, Proteus, Enterobacter, etc.; Acinetobacter, Pseudomonas aeruginosa, etc. Pseudomonas, Staphylococcus, pneumococcus, and hemolytic streptococcus also have certain antibacterial effects. The co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K31/496A61P31/04A61K9/08A61K47/16
Inventor 吴秋萍
Owner 广东好药多医药有限公司
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