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Production technique of crystalline lactulose

A production process and lactulose technology are applied in the production process field of crystalline lactulose, and can solve the problems of difficult removal of ethanol, easy water absorption, unsatisfactory industrial production and the like

Active Publication Date: 2011-08-17
山东绿健生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the crystals obtained from alcohol always contain a certain amount of ethanol, this part of ethanol is difficult to remove. It may be due to the formation of hydrogen bonds between the hydroxyl groups of sugar molecules and alcoholic hydroxyl groups. Even if the drying time is prolonged, it is impossible to completely remove ethanol. , and the cost is high, which is not ideal in industrial production
Due to some disadvantages of crystallization from alcohol, many researchers use vacuum freeze-drying and spray-drying methods to prepare lactulose solids. Even with high-purity syrups, only amorphous solids can be obtained, and the obtained solids are extremely hygroscopic. poor stability

Method used

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  • Production technique of crystalline lactulose
  • Production technique of crystalline lactulose

Examples

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Effect test

Embodiment 1

[0029] Example 1: Weigh 250kg of lactose, add water to make the lactose concentration 60%, then add 1.89kg of anhydrous sodium salt isomerization agent, then heat to 110°C, and maintain 110°C for isomerization for 2 hours, then cool to crystallize, centrifuge, Activated carbon decolorization, ion exchange to obtain a syrup with a lactulose content of 54.42%; evaporate the obtained lactulose syrup to a concentration of 65%, add lactose seed crystals at 1.0%, cool and crystallize at a speed of 2 to 4°C / h, and centrifuge Finally, lactulose syrup with a lactulose content of 79.86% was obtained; the concentration of the lactulose syrup obtained by the secondary crystallization was adjusted to 50%, and it entered the three-way sequential simulated moving bed at a speed of 3.0L / h. Separation was carried out under the condition of 17 minutes, and the content of lactulose in the lactulose component obtained was 91.22%; finally, the purified lactulose was concentrated to 85%, and lactulo...

Embodiment 2

[0030] Example 2: Weigh 250kg of lactose, add water to make the lactose concentration 50%, then add 6.3kg of anhydrous sodium salt isomerization agent, then heat to 90°C, and maintain 90°C for 4 hours, then cool to crystallize, centrifuge, Activated carbon decolorization and ion exchange to obtain a syrup with a lactulose content of 50.49%; evaporate the obtained lactulose syrup to a concentration of 75%, add lactose seed crystals at 0.1%, cool and crystallize at a speed of 6-8°C / h, and centrifuge Finally, lactulose syrup with a lactulose content of 77.25% is obtained; the concentration of the lactulose syrup obtained by secondary crystallization is adjusted to 40%, and it enters the three-way sequential simulated moving bed at a speed of 4.0L / h. Separation was carried out under the condition of 21 minutes, and the content of lactulose in the lactulose component obtained was 90.58%; finally, the purified lactulose was concentrated to 90%, and lactulose seed crystals were added ...

Embodiment 3

[0031]Example 3: Weigh 250kg of lactose, add water to make the lactose concentration 70%, then add 0.63kg of anhydrous sodium salt isomerization agent, then heat to 120°C, and maintain 120°C for 0.5h, then cool to crystallize and centrifuge , activated carbon decolorization, and ion exchange to obtain a syrup with a lactulose content of 52.19%; evaporate the obtained lactulose syrup to a concentration of 55%, add lactose seed crystals at 1.5%, and carry out cooling and crystallization at a speed of 4 to 6°C / h. After centrifugation, a lactulose syrup with a lactulose content of 71.86% was obtained; the concentration of the lactulose syrup obtained by secondary crystallization was adjusted to 60%, and entered into a three-way sequential simulated moving bed at a speed of 2.0L / h. Separation was carried out under the condition of 13 minutes, and the content of lactulose in the obtained lactulose component was 90.22%; finally, the purified lactulose was concentrated to 75%, and lact...

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Abstract

The invention discloses a production technique of crystalline lactulose, which uses lactose as a raw material and comprises the following steps: (1) preparing a lactose solution, adding an isomerizing agent to isomerize the lactose into lactulose under reflux, and centrifugalizing to remove crystalline lactose, thereby obtaining a centrifugate; (2) decoloring the centrifugate in the step (1) with activated carbon, carrying out ion exchange, concentrating by evaporation, cooling, carrying out secondary crystallization on the lactose, and centrifugalizing to obtain a preliminary purification liquid; (3) carrying out three-component sequential type simulated moving bed chromatographic separation on the preliminary purification liquid in the step (2) to obtain three components, including a lactose fraction, a lactulose fraction and an impure saccharide fraction; and (4) concentrating the lactulose component in the step (3) by evaporation, cooling to crystallize, centrifugalizing and drying to obtain the crystalline lactulose. The crystalline lactulose produced by the technique disclosed by the invention has the advantages of good quality and low cost, has obvious economic benefit and social benefit, and is an important breakthrough in the field of lactulose preparation.

Description

technical field [0001] The invention relates to a production process of crystalline lactulose. Background technique [0002] Lactulose is a disaccharide. The glucose in the lactose molecule is replaced by fructose, which is lactulose, which is slightly sweeter than lactose. Lactulose does not exist in nature, it is a synthetic disaccharide, but both boiled milk and condensed milk contain a small amount of lactulose. [0003] Lactulose is not only a good sweetener, but also has physiological functions such as invigorating the stomach, moistening the intestines, and preventing constipation. It can also be used as a functional additive for dairy products, beverages, infants and elderly foods, and can also be made into health drinks For direct consumption. In addition, lactulose has obvious curative effect on the treatment of liver disease and brain disease, so this is a new generation of health care products with medicinal and health value, but also has huge economic benefits...

Claims

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Application Information

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IPC IPC(8): C07H3/04C07H1/06
Inventor 信成夫景文利任尚美
Owner 山东绿健生物技术有限公司
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