Preparation method of water-soluble polysaccharide/hydrophobic monomer formed nanoparticles
A technology of water-soluble polysaccharides and hydrophobic monomers, which is applied in the field of particles and its preparation in the field of nanotechnology, and can solve problems such as cumbersome steps
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Embodiment 1
[0021] Dissolve 0.1g of hydroxypropyl cellulose (molecular weight: 80,000) in 50ml of water, stir until fully dissolved, pass nitrogen to deoxidize for 1 hour, add 0.02g of dilute nitric acid solution of ammonium cerium nitrate under nitrogen protection and uniform stirring, and make the reaction system The final pH is between 1-2. After about 10 minutes, add a dimethyl sulfoxide solution containing 0.06 g of glycidyl methacrylate monomer, add 0.004 g of N,N'-methylenebisacrylamide cross-linking agent after half an hour, and react at 40°C for 5 Hour. After the reaction, transfer to a dialysis bag with a molecular weight cut-off of 14,000, and dialyze in pure water for one week to ensure the removal of impurities such as unreacted monomers in the reaction system, that is, to obtain a stable aqueous solution of nanoparticles based on hydroxypropyl cellulose. Nanoparticles were obtained after freeze-drying.
[0022] The nano particle aqueous solution obtained in the system has ...
Embodiment 2
[0024] Dissolve 0.5 g of dextran (molecular weight: 40,000) in 10 ml of water, stir until it is fully dissolved, pass nitrogen to deoxidize for 1 hour, add 0.05 g of dilute nitric acid solution of ammonium cerium nitrate under nitrogen protection and uniform stirring, and make the reaction system The final pH is between 1-2. After about 10 minutes, add 0.05 g of 3-acrylamidophenylboronic acid monomer (dissolved in 0.5 ml dimethyl sulfoxide), and after 30 minutes, add 0.004 g of N,N′-methylenebisacrylamide cross-linking agent, 30 °C for 4 hours. After the reaction, transfer to a dialysis bag with a molecular weight cut-off of 14,000 and dialyze in pure water for one week to ensure the removal of impurities such as unreacted monomers in the reaction system to obtain a stable aqueous solution of nanoparticles based on dextran. Nanoparticles were obtained after freeze-drying.
[0025] The nanoparticles obtained in this system are observed by transmission electron microscopy as a...
Embodiment 3
[0026] Example 3: Dissolve 5 grams of hydroxyethyl cellulose (molecular weight: 90,000) in 50 milliliters of water, stir until fully dissolved, pass nitrogen to deoxidize for 1 hour, add 0.2 grams of potassium permanganate dilute under nitrogen protection and uniform stirring Nitric acid solution, so that the final pH of the reaction system is between 1-2. After about 10 minutes, an ethanol solution containing 0.5 g of methyl methacrylate monomer was added, and half an hour later, 0.1 g of N,N'-methylenebisacrylamide crosslinking agent was added, and the mixture was reacted at 20°C for 4 hours. After the reaction, transfer to a dialysis bag with a molecular weight cut-off of 14,000, and dialyze in pure water for one week to ensure the removal of impurities such as unreacted monomers in the reaction system, that is, to obtain a stable aqueous solution of nanoparticles based on hydroxyethyl cellulose. Nanoparticles were obtained after freeze-drying.
[0027] The nanoparticles o...
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