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Hydroxytyrosol pellets and preparation method thereof

A technology of hydroxytyrosol and alcohol pellets, which is applied in the directions of food preparation, active ingredients of hydroxy compounds, antidote, etc., can solve the problems of difficult molding and poor stability of hydroxytyrosol, and achieve the advantages of improving bioavailability and increasing absorption rate. Effect

Inactive Publication Date: 2011-08-31
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention studies a process preparation method, overcomes the problems of difficult molding and poor stability of hydroxytyrosol in the prior art, and provides a new preparation of hydroxytyrosol—pellet preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take the raw materials of the following formula for use: 40 grams (40%) of hydroxytyrosol concentrate, 12 grams (12%) of β-cyclodextrin, 8 grams (8%) of hydroxypropyl cellulose, 25 grams (25%) of dextrin ), instant gum arabic 10g (10%), polyvinylpyrrolidone 5g (5%);

[0034] Preparation:

[0035] Dissolve β-cyclodextrin and hydroxypropyl cellulose in hot water at 60-70 °C, stir to dissolve, cool down to 30-35 °C, add hydroxytyrosol concentrate, stir for 1 hour, fully miscible, under 15-20Mpa Homogenize, add dextrin and instant gum arabic to the homogenized liquid, and stir for 1 hour. Dry and pulverize the above liquid to a micronized level and mix well. The polyvinylpyrrolidone was dissolved in 50% ethanol, and pellets were prepared by centrifugal-fluidized pelletizing method.

Embodiment 2

[0037] Take the raw materials of the following formula for use: 45 grams (45%) of hydroxytyrosol concentrate, 10 grams (10%) of β-cyclodextrin, 6 grams (6%) of hydroxypropyl cellulose, 30 grams (30%) of dextrin ), instant gum arabic 8g (8%), polyvinylpyrrolidone 1g (1%);

[0038] Preparation:

[0039] Dissolve β-cyclodextrin and hydroxypropyl cellulose in hot water at 60~70℃, stir to dissolve, cool down to 30~35℃, add hydroxytyrosol concentrate, stir for 1 hour, fully miscible, 15~20Mpa Under the homogenization, dextrin and instant gum arabic were added to the homogenized liquid, and stirred for 1 hour. Dry and pulverize the above liquid to a micronized level and mix well. The polyvinylpyrrolidone was dissolved in 50% ethanol, and pellets were prepared by centrifugal-fluidized pelletizing method.

Embodiment 3

[0041] Take the raw materials of the following formula for use: 45 grams (50%) of hydroxytyrosol concentrate, 10 grams (10%) of β-cyclodextrin, 8 grams (8%) of hydroxypropyl cellulose, 25 grams (25%) of dextrin ), instant gum arabic 10g (10%), polyvinylpyrrolidone 2g (2%);

[0042] Preparation:

[0043] Dissolve β-cyclodextrin and hydroxypropyl cellulose in hot water at 60~70℃, stir to dissolve, cool down to 30~35℃, add hydroxytyrosol concentrate, stir for 1 hour, fully miscible, 15~20Mpa Under the homogenization, dextrin and instant gum arabic were added to the homogenized liquid, and stirred for 1 hour. Dry and pulverize the above liquid to a micronized level and mix well. The polyvinylpyrrolidone was dissolved in 50% ethanol, and the pellets were made by extrusion-spheronization method.

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Abstract

The invention relates to a simple, convenient and easy preparation method of hydroxytyrosol pellets. The invention comprises a technology and preparation method which avoids the problem of difficult form and bad stability of hydroxytyrosol in prior technology and provides a novel hydroxytyrosol preparation, pellets. The invention adopts a micronization technology of crushing the embedded hydroxytyrosol powder into micro powder, the average grain diameter of the micro powder is in general less than 15um, and the micro powder is mainly distributed in the range of 5-20um, so as to improve the active principle absorptivity and the bioavailability; in addition, the invention can raise the internal dissolvability of the phloretin greatly by using water-soluble adhesive and excipient, so as to improve bioavailability of the preparation and accelerate the initial time to become effective. The invention brought in pellets technology which developed rapidly in medical field, can produce the pellet-type product with controllable release in vivo and high bioavailability so as to carry out the preparation and pave the road for hydroxytyrosol application study.

Description

technical field [0001] The invention relates to the technical field of medicine and food, in particular to a hydroxytyrosol pellet and a preparation method thereof. Background technique [0002] 3,4-Dihydroxyphenethyl alcohol (Hydroxytyrosol) was firstly extracted from olive oil with the reputation of "Liquid Platinum", "Oil of Beauty" and "Mediterranean Manna", which is very rare. [0003] Due to its excellent antioxidant properties, its application range is summarized as follows: [0004] 1. It can be used in cardiovascular drugs, and has miraculous effects on the prevention and treatment of arteriosclerosis, hypertension, heart disease, cerebral hemorrhage, etc., and is superior to similar drugs. [0005] 2. As a safe and efficient antioxidant, used in beauty products and health products, it can effectively enhance skin elasticity and moisturizing, and has the effect of wrinkle removal and anti-aging. [0006] 3. Beneficial for the skeletal system: It helps the body to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/05A23L1/29A61P9/10A61P9/12A61P35/00A61P39/06A23L33/00
Inventor 孙华庚
Owner 天津市尖峰天然产物研究开发有限公司
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