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Reagent for inhibiting nitric oxides and nicotiana alkaloids in side-stream smoke from regenerating nitrosamines and preparation method and application thereof

A technology of tobacco alkaloids and sidestream smoke, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of effective elimination, complex pretreatment process of analysis methods, low content, etc., and achieve stable test data and high test results Accurate and reliable results with improved reproducibility

Active Publication Date: 2013-08-14
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low content of tobacco-specific N-nitrosamines (TSNAs) in sidestream smoke, and the presence of nitrogen oxides and tobacco alkaloids regenerating TSNAs under the environmental conditions of sidestream smoking, the determination method It is necessary to eliminate nitrogen oxides and tobacco alkaloids and regenerate TSNAs, which makes the pretreatment process of the analysis method very complicated, so that there is no test method that has been reported in China, and there is no effective test method abroad. Test method for the depletion of nitrogen oxides and tobacco alkaloids and regeneration of TSNAs in sidestream smoking environments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] a. Prepare a saturated aqueous solution of vitamin C in a brown bottle, weigh 200g of the solution in a beaker, slowly add 3g of starch-type sodium carboxymethylcellulose (CMC) to it under magnetic stirring, and stir to dissolve it completely. A solution with a viscosity of 1800 cp was obtained.

[0017] b. Coat the obtained solution on the inner wall of the fishtail hood for sidestream smoke measurement, rotate gently to make the coating even, and then hang the fishtail bottle in a light-proof and ventilated place to let it solidify naturally.

[0018] c. After the Cambridge filter used for suction is treated with 2ml of saturated aqueous solution of vitamin C, it shall be balanced according to the suction standard. Connect the prepared fish tail cover into the side stream catcher with the treated filter disc, connect it into the side stream pipeline to suck the mixed type reference cigarette, and extract the filter disc with dichloromethane after the suction is comple...

Embodiment 2

[0020] a. Prepare a 10% methanol solution of vitamin E in a brown bottle, weigh 100g of the solution in a beaker, slowly add 1g of sodium carboxymethyl cellulose to it under magnetic stirring, stir to make it fully dissolved, and obtain a viscosity of 1000cp solution.

[0021] b. Coat the obtained solution on the inner wall of the fishtail hood for sidestream smoke measurement, rotate gently to make the coating even, and then hang the fishtail hood in a light-proof and ventilated place to let it solidify naturally.

[0022] c. After the Cambridge filter used for suction is treated with 2ml of vitamin E in 10% methanol solution, it shall be balanced according to the suction standard. Connect the prepared fish tail cover into the side stream catcher with the treated filter disc, connect it into the side stream pipeline to suck flue-cured tobacco type reference cigarettes, and extract the filter disc with dichloromethane after the suction is completed. Concentrate, purify by bas...

Embodiment 3

[0024] a. Prepare a 5% ethanol solution of carotene in a brown bottle, weigh 200g of the solution in a beaker, slowly add 2g of starch-type carboxymethylcellulose (CMS) to it under magnetic stirring, and stir to dissolve it completely. A solution with a viscosity of 1500 cp was obtained.

[0025] b. Coat the obtained solution on the inner wall of the fishtail hood for sidestream smoke measurement, rotate gently to make the coating even, and then hang the fishtail bottle in a light-proof and ventilated place to let it solidify naturally.

[0026] c. After the Cambridge filter used for suction is treated with 2ml of carotene in 5% ethanol solution, it shall be balanced according to the suction standard. Connect the prepared fish tail cover into the side stream catcher with the treated filter disc, connect it into the side stream pipeline to suck the mixed type reference cigarette, and extract the filter disc with dichloromethane after the suction is completed, Concentrate, puri...

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Abstract

The invention provides a reagent for inhibiting nitric oxides and nicotiana alkaloids in side-stream smoke from regenerating nitrosamines and a preparation method and application thereof, wherein the reagent is prepared by adding a thickener into a water solution, a methanol solution or ethanol solution of an antioxidant, wherein the weight of the thickener is 0.5-5% of the weight of the solution; the antioxidant is carotenoid, vitamin E or vitamin C; the thickener is carboxymethyl cellulose, sodium carboxymethyl cellulose (CMC) or carboxymethyl starch (CMS). The reagent provided by the invention is suitable for measuring tobacco-specific nitrosamines in side-stream smoke of cigarettes; the reagent is coated on a fish-tail cover for sucking side-stream smoke, so as to effectively inhibit the nitric oxides and nicotiana alkaloids in side-stream smoke from regenerating nitrosamines in a side-stream sucking environment; and therefore, the pre-processing procedure of a testing method is simple, and the measuring result is accurate and reliable.

Description

technical field [0001] The invention relates to a reagent for determining harmful components in sidestream smoke, in particular to a reagent for inhibiting the regeneration of nitrogen oxides and tobacco alkaloids in sidestream smoke into nitrosamines and its preparation method and application. When the chromatographic-thermal energy analyzer is used to measure tobacco-specific nitrosamines in sidestream smoke, the operation steps are greatly simplified, and true and accurate measurement results are obtained. Background technique [0002] As governments, health organizations and the public pay more and more attention to smoking and health issues, harmful components in sidestream smoke from cigarettes have also become one of the focuses of attention. Tobacco-specific N-nitrosamines (TSNAs), as one of the harmful components in tobacco, have attracted great attention from tobacco researchers at home and abroad because of their strong carcinogenicity. Due to the low content of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
Inventor 刘克建王宜鹏赵乐王冰赵晓东余晶晶
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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