Insulin carrier transdermal drug delivery preparation and preparation method thereof
A technology for transdermal drug delivery and insulin, applied in the directions of pharmaceutical formulations, drug combinations, and drug delivery, can solve the problems of weak penetration of insulin drugs, large insulin molecules, and difficulty in absorbing the liver, and achieve strong skin penetration, High encapsulation efficiency and the effect of promoting drug transdermal absorption
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Embodiment 1
[0038] Take 8.0g of soybean phosphatidylcholine, 8.0g of cholesterol, 1.0g of sodium deoxycholate and 1mL of eucalyptus oil, add ethanol, and ultrasonically dissolve; weigh 0.2g of insulin, and use 60mL of 0.01M triethanolamine-hydrochloric acid buffer ( pH=6.2) dissolve, add the obtained solution to the solution obtained above, through the micro-jet, each nozzle hits 8-10 cycles, the pressure is 10 4 pa, make it homogenized and nano-sized to obtain the insulin transfer body solution; take 1g of carbomer, add appropriate amount of water to make a gel matrix, slowly add the insulin transfer body solution to it, stir evenly, and obtain.
[0039] The physical properties of the insulin delivery body transdermal drug delivery preparation that the present embodiment makes:
[0040] According to the particle size measurement, the transdermal insulin transfer body formulation of this example has a uniform particle size (200-300nm); measured by ultracentrifugation, the encapsulation ra...
Embodiment 2
[0051] Take 30.0g of distearoylphosphatidylcholine, 30.0g of cholesterol, 5.0g of sodium cholate, 3mL of geranium oil and 2mL of L-menthol, add 30ml of ethanol, and ultrasonically dissolve it; weigh 1.0g of insulin, and use 80mL of 0.01 Dissolve M triethanolamine-hydrochloric acid buffer solution (pH=6.0), add the obtained solution to the solution obtained above, and make it homogenized and nano-sized by micro-jet to obtain the insulin transfer body solution; take 5g xanthan gum, add appropriate amount of water A gel matrix is prepared, and the insulin transfer body solution is slowly added thereto, and the mixture is evenly stirred to obtain the product.
[0052] The physical properties of the insulin delivery body transdermal drug delivery preparation that the present embodiment makes:
[0053] According to the particle size measurement, the insulin transfer body transdermal drug delivery preparation of this example has a uniform particle size (200-300nm); measured by ultr...
Embodiment 3
[0064] Take 24.0g of distearoylphosphatidylethanolamine, 24.0g of cholesterol, 1.7g of sodium deoxycholate, 1.5mL of L-menthol and 0.5mL of turpentine, add 20ml of ethanol, and ultrasonically dissolve them; weigh 0.4g of insulin, and use 64mL Dissolve 0.01M triethanolamine-hydrochloric acid buffer solution (pH=6.8), add the obtained solution to the above obtained solution, and make it homogenized and nanometerized by micro-jet to obtain the insulin transfer body solution; take 2.5g of poloxamer 188, Add an appropriate amount of water to make a gel base, slowly add the insulin transfer body solution to it, and stir evenly to obtain the gel matrix.
[0065] The physical properties of the insulin delivery body transdermal drug delivery preparation that the present embodiment makes:
[0066] According to the particle size measurement, the transdermal insulin transfer body formulation of this example has a uniform particle size (200-300nm); measured by ultracentrifugation, the enca...
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