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Chinese medicinal dispersible tablets for treating gastritis and preparation method thereof

A technology for dispersible tablets and traditional Chinese medicine, which is applied in the directions of pharmaceutical formulations, medical raw materials derived from birds, medical preparations with inactive ingredients, etc. The effect of short solution time, accelerated absorption and convenient taking

Active Publication Date: 2012-09-26
JIANGSU TIANZHAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, such traditional Chinese medicine preparations are marketed as capsules or tablets. Although these traditional Chinese medicines have certain curative effects on the above-mentioned diseases, they have problems such as long disintegration time, slow absorption, and inconvenience for elderly children.

Method used

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  • Chinese medicinal dispersible tablets for treating gastritis and preparation method thereof
  • Chinese medicinal dispersible tablets for treating gastritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Ratio of raw medicinal materials: Astragalus 198g, Salvia miltiorrhiza 198g, Phellodendron 198g, Chonglou 119g, Licorice 119g, Curcuma 119g, Polygonum cuspidatum 198g, Panax notoginseng 132g, Hedyotis diffusa 198g, Gallus gallus 119g, Atractylodes macrocephala 119g, Baizhu and 132g;

[0036] (2) Grinding gallinacea and Panax notoginseng into a fine powder of 150-200 mesh to obtain 245g of fine powder, which is set aside;

[0037] (3) The remaining astragalus and other ten medicinal materials are crushed into coarse powder, decocted with water three times, add 10 times the amount of water for 2 hours for the first time, add 8 times the amount of water for 1.5 hours for the second time, and add 6 times the amount of water for the third time. Decoct with twice the amount of water for 1 hour, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.35-1.38 (60°C), dry it in a vacuum, and grind it in...

Embodiment 2

[0041] (1) The composition ratio of the original medicinal materials is the same as in Example 1. According to the preparation method of Example 1, 230 g of Panax notoginseng, Gallinaceae fine powder, and 205 g of extract powder can be obtained.

[0042] (2) Ratio of excipients: 56g of microcrystalline cellulose, 24g of low-substituted hydroxypropyl cellulose, 80g of cross-linked polyvinylpyrrolidone (45g before granulation, 35g before tableting), 6g of aspartame, 6g of micronized silica gel

[0043] Its preparation method is identical with embodiment 1, can make 1000 Chinese medicine dispersible tablets for the treatment of gastritis.

Embodiment 3

[0045] (1) The composition ratio of the original medicinal materials is the same as in Example 1. According to the preparation method of Example 1, 235 g of Panax notoginseng, Gallinaceae fine powder, and 185 g of extract powder can be obtained.

[0046] (4) The proportion of auxiliary materials is: microcrystalline cellulose 70g, low-substituted hydroxypropyl cellulose 30g, cross-linked polyvinylpyrrolidone 80g (47g before granulation, 33g before tableting), 6g aspartame, 6g micronized silica gel

[0047] Its preparation method is identical with embodiment 1, can make 1000 Chinese medicine dispersible tablets for the treatment of gastritis.

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Abstract

The invention relates to Chinese medicinal dispersible tablets for treating gastritis, which have the advantages of quick disintegration and high bioavailability. The Chinese medicinal dispersible tablets consist of 36 to 42 percent of raw material medicine I with the fineness of 150-1200 meshes, 28 to 36 percent of raw material medicine II active ingredient extract and 24 to 34 percent of auxiliary material, wherein the raw material medicine I consists of 107 to 131 parts of chicken's gizzardskin and 118 to 146 parts of pseudo-ginseng; and the raw material medicine II consists of 178 to 218 parts of astragali, 178 to 218 parts of root of red-rooted salvia, 178 to 218 parts of phellodendron, 107 to 131 parts of Yunnan manyleaf paris rhizome, 107 to 131 parts of liquorice, 107 to 131 partsof zedoary, 178 to 218 parts of giant knotweed, 178 to 218 parts of spreading hedyotis herb, 107 to 131 parts of largehead atractylodes rhizome, and 118 to 146 parts of common bletilla pseudobulb. The preparation method comprises the steps of: mixing the raw material medicine I, the raw material medicine II active ingredient extract and the auxiliary material, granulating, adding a lubricant and a disintegrating agent, and tabletting to obtain the Chinese medicinal dispersible tablets.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine dispersible tablet for treating acute and chronic gastritis and chronic atrophic gastritis and a preparation method thereof. Background technique: [0002] It is a traditional Chinese medicine used to treat acute and chronic gastritis and chronic atrophic gastritis caused by spleen deficiency, qi stagnation and blood stasis. Its main function is to strengthen the spleen and stomach, remove blood stasis and relieve pain. At present, such traditional Chinese medicine preparations are marketed as capsules or tablets. Although traditional Chinese medicines in this dosage form have certain curative effects on the above-mentioned diseases, they have problems such as long disintegration time, slow absorption, and inconvenience for elderly children to take. Traditional Chinese medicines for the treatment of acute and chronic gastritis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/9066A61K47/38A61P1/04A61K35/37A61K35/57
Inventor 周光治张立冬李德友
Owner JIANGSU TIANZHAO PHARMA