Polyvinyl alcohol-polypeptide-polyethylene glycol graft copolymer and preparation method thereof

A technology of polyethylene glycol grafting and graft copolymer is applied in the field of biopolymer material preparation to achieve the effect of easy preparation

Inactive Publication Date: 2011-09-14
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this graft copolymer has not been reported in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Step 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups

[0024] Add 34.4 grams of PBLG (molecular weight is 4000), 15 grams of toluene diisocyanate in the dry reaction bottle, add 200 grams of dimethyl sulfoxide to dissolve, add the dibutyltin dilaurate of above-mentioned reactant gross weight 3‰ in addition, inert atmosphere , stirred at 55°C for 70 minutes, terminated the reaction, and washed off excess toluene diisocyanate with petroleum ether to obtain the target product.

[0025] Step 2) synthesis of polyvinyl alcohol-polypeptide graft copolymer

[0026] Add 12 grams of polypeptide homopolymers containing terminal-NCO groups, 12 grams of polyvinyl alcohol (molecular weight is 20000) in the dry reaction bottle, add 200 grams of dimethyl sulfoxide to dissolve, add the total weight of the above reactants 3 ‰ of dibutyltin dilaurate, under an inert atmosphere, stirred at 60°C for 120 minutes, then terminated the reaction, and then obtained polyvi...

Embodiment 2

[0030] Step 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups

[0031] Add 19 grams of PBLG (molecular weight: 8000), 10 grams of hexamethylene diisocyanate into the dry reaction bottle, add 200 grams of dimethyl sulfoxide to dissolve, and add dibutyltin dilaurate with a total weight of 3‰ of the above-mentioned reactants, under an inert atmosphere , stirred and reacted at 60° C. for 65 minutes, terminated the reaction, and washed off excess hexamethylene diisocyanate with petroleum ether to obtain the target product.

[0032] Step 2) synthesis of polyvinyl alcohol-polypeptide graft copolymer

[0033] Add 12 grams of polypeptide homopolymers containing terminal-NCO groups, 10 grams of polyvinyl alcohol (molecular weight is 80000) in the dry reaction bottle, add 200 grams of dimethyl sulfoxide to dissolve, add the total weight of the above reactants 3 ‰ of dibutyltin dilaurate, under an inert atmosphere, stirred at 65°C for 110 minutes, then terminated th...

Embodiment 3

[0038] Step 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups

[0039] Add 18 grams of PBLG (molecular weight is 4000), 18 grams of diphenylmethane diisocyanate into the dry reaction bottle, add 200 grams of dimethyl sulfoxide to dissolve, and add dibutyltin dilaurate with a total weight of 3‰ of the above reactants , under an inert atmosphere, stirred and reacted at 65° C. for 60 minutes, terminated the reaction, and washed off excess diphenylmethane diisocyanate with petroleum ether to obtain the target product.

[0040] Step 2) synthesis of polyvinyl alcohol-polypeptide graft copolymer

[0041] Add 8 grams of polypeptide homopolymers containing terminal-NCO groups, 8 grams of polyvinyl alcohol (molecular weight is 30000) in the dry reaction bottle, add 200 grams of dimethyl sulfoxide to dissolve, add the total weight of the above reactants 3 ‰ of dibutyltin dilaurate, under an inert atmosphere, stirred at 70°C for 100 minutes and then terminated the r...

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PUM

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Abstract

The invention relates to a polyvinyl alcohol-polypeptide-polyethylene glycol graft copolymer and a preparation method thereof. The molecular weight of polyvinyl alcohol is 20,000-80,000; the molecular weight of a polypeptide chain segment is 4,000-8,000; and the molecular weight of a polyethylene glycol chain segment is 350-750. The preparation method comprises the following steps of: (1) synthesizing a polypeptide homopolymer which contains an end-NCO radical: adding the polypeptide homopolymer, diisocyanate, dibutyltin dilaurate serving as a catalyst and dimethyl sulfoxide serving as a solvent into a reactor for reacting to obtain a target product; (2) synthesizing a polyvinyl alcohol-polypeptide graft copolymer: adding the polypeptide homopolymer which contains the end-NCO radical, the solvent and the catalyst into the reactor, adding polyvinyl alcohol and reacting to obtain a target product; and (3) synthesizing a polyvinyl alcohol-polypeptide-polyethylene glycol graft copolymer: adding the polyvinyl alcohol-polypeptide graft copolymer, the solvent and the catalyst into a drying reactor, adding polyethylene glycol monomethyl ether and reacting to obtain a target product.

Description

technical field [0001] The invention relates to a polyvinyl alcohol-polypeptide-polyethylene glycol graft copolymer and a preparation method thereof, belonging to the technical field of biopolymer material preparation. Background technique [0002] Polyvinyl alcohol is a water-soluble polyhydroxy polymer. The hydroxyl group (-OH) contained in the molecular chain can cause strong hydrogen bond interaction between the molecule and the molecule, and can obtain polymers with good physical and mechanical properties. Materials, such as good flexibility and elasticity, etc. At the same time, polyvinyl alcohol also has properties such as non-toxicity, no side effects, excellent biodegradability and biocompatibility, and no allergic reaction, so it has been widely used in the field of biomedicine for burn and trauma treatment , plastic surgery, preparation of slow-release drug carriers, solid-phase enzyme carriers, artificial vitreous body, artificial cartilage prosthesis, etc. [Zhe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G81/02C08G69/48C08G65/48
Inventor 朱国全王发刚李国昌柳玉英高巧春王萍巩丽
Owner SHANDONG UNIV OF TECH
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