Bufo bufo gargarizans cantor skin extract dry powder inhalant and preparation method and use thereof

A dry powder inhaler and dry powder inhaler technology are applied in the application field of preparing medicines for treating lung tumors, which can solve problems such as no research reports, and achieve the effects of no liver first pass, convenient application, and small adverse reactions.

Active Publication Date: 2011-10-12
南通思启高家具有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the study of toad skin extrac

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1

[0029] 1. Preparation of toad skin extract: wash dry toad skin, add 10 times the amount of water, decoct 2 times, 1.5 hours each time, combine the filtrate, concentrate to a relative density of 1.1-1.2 (85℃), and cool to Add ethanol to precipitate at 40°C to make the alcohol content reach 60%. Let stand for 24 hours. Take the supernatant to recover the ethanol until it has no alcohol taste. Add ethanol to the concentrate to make the alcohol content reach 85%. Let stand for 48 hours and filter. , Recycle ethanol to thick paste, and dry at 60°C to obtain toad skin extract.

[0030] 2. Preparation of inhalant: the toad skin extract is crushed to D by airflow 50 Below 5 microns, it is mixed with lactose with a particle size of 45-70 microns at a mass ratio of 1:10, and the drug powder is packaged into a capsule or blister or dry powder inhaler to obtain an inhalant.

Example Embodiment

[0031] Example 2

[0032] 1. Preparation of toad skin extract: wash dry toad skin, add 12 times the amount of water, decoct 2 times, 2 hours each time, combine the filtrate, concentrate to a relative density of 1.2-1.3 (85℃), and cool to Precipitate with ethanol at 40℃ to make the alcohol content reach 70%. Let stand for 24 hours. Take the upper liquid to recover the ethanol until it has no alcohol smell. Add ethanol to the concentrate to make the alcohol content reach 85%. Let stand for 48 hours and filter. , Recycle ethanol to no alcohol taste, spray dry, get toad skin extract powder, powder D 50 Below 5 microns.

[0033] 2. Preparation of inhalants: mix the toad skin extract powder, lactose with a particle size of 45-80 microns, and leucine with a particle size of 20-50 microns in a mass ratio of 10:100:1, and pack into Get the inhalant in a capsule or blister or dry powder inhaler.

Example Embodiment

[0034] Example 3

[0035] 1. Preparation of toad skin extract: take dry toad skin and wash, add 30 times the amount of water, and extract 3 times with microwave assisted extraction for 1 hour each time. Combine the extracts, ultrafiltration through ultrafiltration membrane with molecular weight 1000, and ultrafiltrate Spray drying to get toad skin extract powder, powder D 50 Below 5 microns.

[0036] 2. Preparation of inhalant: Pack the toad skin extract powder into a capsule or blister or dry powder inhaler to obtain an inhalant.

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Abstract

The invention relates to dry powder inhalants, in particular to a dry powder inhalant prepared from bufo bufo gargarizans cantor skin extract, the preparation method of the dry powder inhalant and the use of the dry powder inhalant in preparation of medicines for treating lung tumors. The dry powder inhalant is characterized by consisting of bufo bufo gargarizans cantor skin extract and medicallyacceptable auxiliary material in a mass ratio ranging from 1:0 to 1:110. The dry powder inhalant made of the bufo bufo gargarizans cantor skin extract can directly act on lung diseases with less toxic and side reactions and high medicine bioavailability; the dry powder inhalant can overcome the drawbacks of slow effectiveness, undesirable liver firstpass effect, body toxic and side effects, low biological bioavailability and the like; and the dry powder inhalant also can solve the problems of inconvenient use, low obedience in patients and the like of powder injections.

Description

Technical field: [0001] The invention relates to a dry powder inhaler, in particular to a dry powder inhaler made of toad skin extract, a preparation method of the dry powder inhaler and an application in the preparation of a drug for treating lung tumors. Background technique: [0002] Cinobufacin is an extract obtained by extracting and purifying the dried skin of Bufobufo gargarizans Cantor, an animal of the Bufonidae family. It has the effects of detoxification, swelling, and pain relief. etc., the physiologically active substances are mainly bufotoxins and their hydrolysis products bufageins, bufoteinines and so on. At present, cinobufacin injections, oral liquids, and tablets have been used clinically, and have good curative effects on liver cancer, lung cancer, and gastric cancer. In particular, cinobufacin injection, which is a water-soluble preparation processed from the skin of Bufo bufo, has achieved comprehensive effective rates of 44% and 56% in the treatment o...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K9/14A61K9/16A61P35/00A61K35/65
Inventor 陈彦张振海贾晓斌王晋艳贺俊杰
Owner 南通思启高家具有限公司
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