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Rifaximin suspension containing montmorillonite and preparation method thereof

A technology for rifaximin and suspension, which is applied in the field of rifaximin suspension and its preparation, can solve the problems of inappropriate dosage form and inability to effectively control the death of diseased livestock and poultry, and achieve long-term preservation and improvement. Bioavailability, easy-to-use effects

Active Publication Date: 2011-10-19
江苏基宇生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing rifaximin drug dosage forms are not suitable for animal clinical application; in addition, the existing rifaximin drugs cannot effectively control the death of sick livestock and poultry due to diarrhea

Method used

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  • Rifaximin suspension containing montmorillonite and preparation method thereof
  • Rifaximin suspension containing montmorillonite and preparation method thereof
  • Rifaximin suspension containing montmorillonite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 The preparation of the rifaximin suspension containing montmorillonite in the present invention

[0025] Proceed as follows:

[0026] (1) Add 100 g of sodium carboxymethyl cellulose, 50 g of Tween-80, and 50 g of sodium citrate into 10 L of water, mix them, and put them in a water bath at 65° C. for 2 hours to prepare a mixed solution.

[0027] (2) Put 1000 g of rifaximin, 1500 g of montmorillonite and the mixed solution of step (1) in a stirrer, and stir at 1250 rpm for 10 min; transfer the resulting solution to a quantitative container, and dilute to 10 L with water.

[0028] (3) Transfer the solution after constant volume in step (2) to a stirrer, stir for 30 minutes, make it fully mixed, and then homogenize with a homogenizer at 38°C and a pressure of 40 kPa, and the obtained The solution was poured into a vial to seal while stirring, and sterilized by flowing steam at 100° C. for 30 minutes to obtain the rifaximin suspension of the present invention. ...

Embodiment 2

[0029] Embodiment 2 Preparation of rifaximin suspension containing montmorillonite in the present invention

[0030] Proceed as follows

[0031] (1) Add 200 g of ethyl cellulose, 20 g of polyethylene glycol, and 20 g of sodium citrate into 10 L of water for mixing, and place in a water bath at 65° C. for 2 hours to prepare a mixed solution.

[0032] (2), 500g of rifaximin, 750g of montmorillonite and the mixed solution of step (1) are placed in a stirrer, stirred at 800rpm; the liquid obtained by stirring is transferred to a quantitative container, and constant volume with water to 10L.

[0033] (3), transfer the solution after step (2) constant volume to the agitator, stir for 30min, fully mix it, and then use a homogenizer to homogenize at 40°C and a pressure of 30 kPa. The obtained solution was poured into a vial to seal while stirring, and sterilized by flowing steam at 100° C. for 30 minutes to obtain the rifaximin suspension of the present invention.

Embodiment 3

[0034] Embodiment 3 Preparation of rifaximin suspension containing montmorillonite in the present invention

[0035] Proceed as follows:

[0036] (1) Add 200 g of sodium carboxymethyl cellulose, 60 g of Span-80, 40 g of glycerol, and 100 g of sodium citrate into 10 L of water and mix them in a water bath at 65°C for 2 hours to obtain a mixed solution.

[0037] (2) 1500g of rifaximin, 2250g of montmorillonite and the mixed solution of step (1) are placed in the stirrer, stirred under the condition of 1000rpm; 10L.

[0038] (3) Transfer the solution after constant volume in step (2) to a stirrer, stir for 30 minutes, fully mix it, and then homogenize it with a homogenizer at 39 ° C and a pressure of 35 kPa. The obtained solution was poured into a vial to seal while stirring, and sterilized by flowing steam at 100° C. for 30 minutes to obtain the rifaximin suspension of the present invention.

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Abstract

The invention discloses rifaximin suspension containing montmorillonite, which belongs to the field of veterinary preparations. The rifaximin suspension comprises the following components by weight percent: 5-15% of rifaximin, 7.5-22.5% of the montmorillonite, 0.5-2% of suspending agent, 0.2-1% of surface active agent, 0.2-1% of deflocculating agent and the balance of water. The invention further discloses a preparation method of the rifaximin suspension, which comprises the following steps: adding the suspending agent, the surface active agent and the deflocculating agent into the water according to proportion, uniformly mixing and performing water bathing for 1-3 hours at the temperature of 65 DEG C; further adding the rifaximin and the montmorillonite into a stirrer for stirring; and adding the water to volume, homogenizing and sterilizing. The rifaximin in the rifaximin suspension is small in particle size, the release amount and the release speed of active ingredients are greatly improved, and the bioavailability of the rifaximin is improved; secondly, the mortality rate of livestock and poultry with diseases caused by diarrhea can be reduced; in addition, the rifaximin suspension is good in stability and suitable for long-term preservation.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a rifaximin suspension containing montmorillonite and a preparation method thereof. Background technique [0002] Diarrhea caused by pathogenic enteric bacteria is a common condition in the livestock and poultry industry. After the animals get sick, the growth rate is slow, and the feed remuneration is reduced. At the same time, due to diarrhea, the animal's physique declines, the immune function weakens, and the resistance to the disease is weakened. caused serious economic losses. Due to the complexity of the etiology and the continuous enhancement of bacterial drug resistance, the currently used antibiotics have no significant effect on the prevention and treatment of bacterial diarrhea. Therefore, seeking high-efficiency, low-toxicity and safe drugs for preventing and treating intestinal bacterial diseases of livestock and poultry such as pigs and chi...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K31/437A61K9/10A61P1/12A61P31/04
Inventor 彭麟江善祥蔡冬万荣峰季辉周显龙张军忍施宗傲
Owner 江苏基宇生物医药科技有限公司
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