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Rifaximin suspension containing montmorillonite and preparation method thereof

A rifaximin and suspension technology, applied in the field of rifaximin suspension and its preparation, can solve problems such as unsuitable dosage form, inability to effectively control the death of sick livestock and poultry, and achieve suitable for long-term storage, improve Bioavailability, Ease of Use Effect

Active Publication Date: 2012-10-10
江苏基宇生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing rifaximin drug dosage forms are not suitable for animal clinical application; in addition, the existing rifaximin drugs cannot effectively control the death of sick livestock and poultry due to diarrhea

Method used

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  • Rifaximin suspension containing montmorillonite and preparation method thereof
  • Rifaximin suspension containing montmorillonite and preparation method thereof
  • Rifaximin suspension containing montmorillonite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of rifaximin suspension containing montmorillonite of the present invention

[0025] Proceed as follows:

[0026] (1) Add 100 g of sodium carboxymethyl cellulose, 50 g of Tween-80, and 50 g of sodium citrate to 10 L of water and mix, and in a water bath at 65° C. for 2 hours to prepare a mixed solution.

[0027] (2) Place 1000 g of rifaximin, 1500 g of montmorillonite, and the mixed solution of step (1) in a stirrer and stir at 1250 rpm for 10 min; transfer the resulting solution to a quantitative container and dilute to 10 L with water.

[0028] (3) Transfer the solution in step (2) to a stirrer, stir for 30 minutes to make it fully mixed, and then homogenize with a homogenizer at 38°C and a pressure of 40 kPa. The solution was poured into a vial and sealed while being stirred, and sterilized by steam at 100°C for 30 minutes to obtain the rifaximin suspension of the present invention.

Embodiment 2

[0029] Example 2 Preparation of rifaximin suspension containing smectite of the present invention

[0030] Proceed as follows

[0031] (1) Add 200 g of ethyl cellulose, 20 g of polyethylene glycol, and 20 g of sodium citrate to 10 L of water and mix them in a water bath at 65°C for 2 hours to prepare a mixed solution.

[0032] (2) Put 500g of rifaximin, 750g of montmorillonite and the mixed solution of step (1) in a stirrer, and stir at 800rpm; transfer the liquid obtained by stirring to a quantitative container, and make the volume constant with water To 10L.

[0033] (3). Transfer the solution in step (2) to a stirrer, stir for 30 minutes, mix it thoroughly, and then homogenize with a homogenizer at 40°C and a pressure of 30 kPa. The obtained solution was poured into a vial and sealed while being stirred, and sterilized with steam at 100°C for 30 minutes to obtain the rifaximin suspension of the present invention.

Embodiment 3

[0034] Example 3 Preparation of rifaximin suspension containing montmorillonite of the present invention

[0035] Proceed as follows:

[0036] (1) Add 200 g of sodium carboxymethyl cellulose, 60 g of Span-80, 40 g of glycerol, and 100 g of sodium citrate to 10 L of water and mix them in a water bath at 65°C for 2 hours to obtain a mixed solution.

[0037] (2) Put 1500 g of rifaximin, 2250 g of montmorillonite and the mixed solution of step (1) in a stirrer and stir at 1000 rpm; transfer the stirred liquid to a quantitative container, and dilute to volume with water 10L.

[0038] (3) Transfer the solution in step (2) to a stirrer, stir for 30 minutes, mix it thoroughly, and then homogenize with a homogenizer at 39°C and a pressure of 35 kPa. The obtained solution was poured into a vial and sealed while being stirred, and sterilized with steam at 100°C for 30 minutes to obtain the rifaximin suspension of the present invention.

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PUM

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Abstract

The invention discloses rifaximin suspension containing montmorillonite, which belongs to the field of veterinary preparations. The rifaximin suspension comprises the following components by weight percent: 5-15% of rifaximin, 7.5-22.5% of the montmorillonite, 0.5-2% of suspending agent, 0.2-1% of surface active agent, 0.2-1% of deflocculating agent and the balance of water. The invention furtherdiscloses a preparation method of the rifaximin suspension, which comprises the following steps: adding the suspending agent, the surface active agent and the deflocculating agent into the water according to proportion, uniformly mixing and performing water bathing for 1-3 hours at the temperature of 65 DEG C; further adding the rifaximin and the montmorillonite into a stirrer for stirring; and adding the water to volume, homogenizing and sterilizing. The rifaximin in the rifaximin suspension is small in particle size, the release amount and the release speed of active ingredients are greatlyimproved, and the bioavailability of the rifaximin is improved; secondly, the mortality rate of livestock and poultry with diseases caused by diarrhea can be reduced; in addition, the rifaximin suspension is good in stability and suitable for long-term preservation.

Description

Technical field [0001] The invention belongs to the field of veterinary drug preparations, and specifically relates to a rifaximin suspension containing montmorillonite and a preparation method thereof. Background technique [0002] Diarrhea caused by pathogenic intestinal bacteria is a common disease in the livestock and poultry breeding industry. After the animal becomes ill, the growth rate is slow and the feed remuneration is reduced. At the same time, due to diarrhea, the animal's physical fitness is weakened, the immune function is weakened, and the resistance to the disease is weakened. It is easy to develop other infectious diseases. If the treatment is not timely, a large number of deaths will be caused to the breeding industry. Caused serious economic losses. Due to the complexity of the etiology and the increasing resistance of bacteria, the currently used antibiotics are not effective in preventing and treating bacterial diarrhea. Therefore, the search for highly ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/06A61K31/437A61K9/10A61P1/12A61P31/04
Inventor 彭麟江善祥蔡冬万荣峰季辉周显龙张军忍施宗傲
Owner 江苏基宇生物医药科技有限公司