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Preparation method for macroporous hydroxyapatite ceramic

A technology of macroporous hydroxyapatite and ceramics, applied in the field of ceramic materials, can solve the problems of easy introduction of impurities and inflexible control of pore structure, and achieve the effects of simplified procedures, low cost, and enlarged macropore diameter

Inactive Publication Date: 2013-06-12
NORTHEASTERN UNIV LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Based on the above analysis and summary of the current status of the preparation of macroporous hydroxyapatite, it can be seen that its preparation mainly relies on the use of pore-forming agents and template agents, and has disadvantages such as easy introduction of impurities and inflexible control of pore structure.

Method used

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  • Preparation method for macroporous hydroxyapatite ceramic
  • Preparation method for macroporous hydroxyapatite ceramic
  • Preparation method for macroporous hydroxyapatite ceramic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: adopt the uniform aqueous solution of the polyvinyl alcohol 2099 that concentration is 6.75wt% (polymerization degree is 2000, alcoholysis degree is 99%) as binder, use concentrated hydrochloric acid (37%, mass fraction) to adjust polyvinyl alcohol After the pH value reaches 6, the hydroxyapatite, the powder with a particle size of 100 nanometers and the polyvinyl alcohol aqueous solution are added to the polypropylene tank in a mass ratio of 4:22, without the surfactant dodecyl sulfate. Sodium; add corundum balls according to the ratio of ball to material to ball to material of 1.5:1, seal, slowly mix until uniform, and then shake for 0.5 hours, and transfer the slurry after shaking to -17 o C in the container, put it in the freezer and continue to freeze for 9 hours. The frozen samples were directly transferred to anhydrous or industrial ethanol to extract the water in the samples. The extraction time was 5 hours. The extraction process was repeated agai...

Embodiment 2

[0039] Embodiment 2: the preparation process is the same as in Example 1, except that the hydroxyapatite particle size is that 100 nanometer powder and the polyvinyl alcohol aqueous solution are mixed in a mass ratio of 4.5:22;

[0040] Depend on image 3 It can be seen that the macropore pore size of the macroporous hydroxyapatite ceramic prepared in this example is 120 μm. When the content of polyvinyl alcohol is constant, the increase of the amount of hydroxyapatite causes the pore size to increase, and the connectivity is good; Figure 4 The laser confocal optical photos clearly show that the connecting holes between the macropores have a diameter of 30-70 μm.

Embodiment 3

[0041] Example 3: The difference between the preparation process and Example 1 is that after shaking for 0.5 hours, mechanical stirring was performed for 10 minutes, and the rotational speed was 1200 rpm.

[0042] Depend on Figure 5 It can be seen that the macropore diameter of macroporous hydroxyapatite ceramics prepared in this example is 150-200 μm. When the content of hydroxyapatite is constant, the increase of polyvinyl alcohol makes the pore size gradually increase and the pore wall gradually becomes thinner, and the connectivity better.

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Abstract

The invention relates to the technical field of ceramic materials, and in particular to a preparation method of macroporous hydroxyapatite ceramics. First, prepare a uniform binder polyvinyl alcohol aqueous solution, use concentrated hydrochloric acid to adjust the pH value of the polyvinyl alcohol to 4 to 5.5, then mix the HA powder and the polyvinyl alcohol aqueous solution at a mass ratio of 2 to 5:10 to 20. To form a uniform slurry, add the surfactant sodium lauryl sulfate; add the slurry into a polypropylene tank, add corundum pellets at a ball-to-material ratio of 1.5:1, seal the polypropylene tank, and mix slowly until uniform; Then shake or mechanically stir the slurry evenly to introduce bubbles; transfer the evenly shaken slurry to a container at -17°C, freeze it for 4 to 12 hours, and extract the water in the frozen slurry at room temperature or under freezing conditions. Then dry it; finally complete the sintering in the air, the sintering temperature is 1000~1200℃, and the holding time is 0.5~2h.

Description

technical field [0001] The invention relates to the technical field of ceramic materials, in particular to a preparation method of macroporous hydroxyapatite ceramics. Background technique [0002] Biomaterials are materials that are used for medical purposes to come into contact with tissue to form a function. Bioceramics, as an important biological material, usually refers to ceramics used for artificial tooth production, repair of bone and cartilage and other tissues, defect filling, and bone tissue engineering such as spine surgery. Among them, hydroxyapatite (HA) and tricalcium phosphate (TCP) have excellent biocompatibility and biosafety due to their inorganic components similar to natural bone tissue, and can form with bone tissue after implantation. Bone bonding, known as bioactive materials, has been used as a material for bone repair. Academician Zhang Xingdong's research group used porous active bioceramics to treat 40 cases of bone defects and achieved satisfac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56C04B35/447C04B35/622
Inventor 王伟常青楚宝帅林春青陈思茹红强
Owner NORTHEASTERN UNIV LIAONING