Method for preparing N-phenyl succinimide

Abstract

The invention relates to a method for preparing N-phenyl succinimide. The method comprises the following steps: step 1, adding A mol of succinic anhydride and B mol of aniline to a reactor, heating the reactor to 100 to 140 DEG C, and refluxing for 30 to 60 min with stirring; and step 2, cooling a mixture obtained in step 1 to room temperature, adding C mL of water to the mixture, cooling to 3 to7 DEG C, adding a strong acid with stirring to adjust the pH to 3 to 4, extraction-filtering, washing, drying products at the temperature of 60 to 100 DEG C, and recrystallizing with water. So a white crystal N-phenyl succinimide is obtained with A:B being equal to 1:(1.2-2) and C being equal to 200A. The method with the heating temperature in the range of 100 to 140 DEG C allows the reaction to be mild, byproducts to be less, and the yield to be more than 80%.

Description

【Technical field】

[0001] The invention belongs to the field of chemical synthesis, in particular to a method for preparing N-phenylsuccinimide. 【Background technique】

[0002] Succinimide, abbreviated as NHS, also known as succinimide, is a product of acylation reaction between succinic anhydride and amine compounds.

[0003] The hydrogen atom on the nitrogen atom of succinimide is weakly acidic, K=3×10 -11 (25°C), it can be substituted by alkali metal to form a salt, and the reaction of this salt with halogenated hydrocarbon can produce a series of N-hydroxyl substituted derivatives, which are very important in organic synthesis, for example, β-amino acid and its derivatives can be synthesized. Therefore, succinimide is mostly used as a raw material for organic synthesis, and can be used to synthesize N-bromosuccinimide or N-chlorosuccinimide. It is also commonly used as an important intermediate for the preparation of medicines and pesticides. Analytical reagents or used...