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Composite porous support material and preparation method thereof

A technology of porous scaffolds and raw materials, applied in the field of materials, can solve the problems of long time and high preparation pressure, and achieve the effects of high porosity, uniform pore size, good adhesion and proliferation state

Inactive Publication Date: 2011-11-16
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in existing reports, using supercritical CO 2 Most of the prepared scaffold materials have relatively small apertures, most of which are below 100 μm, and the preparation pressure is high and the time is long
Moreover, in existing reports and patents, there is no simultaneous use of polylactic acid-glycolic acid copolymer, hydroxyapatite and collagen to prepare porous scaffold materials.

Method used

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  • Composite porous support material and preparation method thereof
  • Composite porous support material and preparation method thereof
  • Composite porous support material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Taking the preparation of 100g of composite porous scaffold material as an example, the raw materials used and their proportioning ratio are:

[0052] Polylactic acid-polyglycolic acid copolymer 95g

[0053] Hydroxyapatite 2.5g

[0054] Collagen 2.5g

[0055] Its preparation method is as follows:

[0056] Take 95g of polylactic acid-polyglycolic acid copolymer, 2.5g of hydroxyapatite, and 2.5g of collagen, mix them evenly, and cold press them into a disc with a diameter of 3cm and a thickness of 1.5cm with a tablet machine. The specific size of the disc is It can be determined according to the size of the reactor within the range of 2-5 cm in diameter and 1-2 cm in thickness. Put the pellets into the mold, and the mold is placed in supercritical CO 2 In the reactor, turn off the CO 2 Vent valve, set reaction pressure to 18MPa, reaction temperature to 45°C, CO 2 Flow rate is 10mL / min, open CO 2 Cylinder valve, high-pressure pump and temperature control valve, make t...

Embodiment 2

[0059] In Example 1, the mold was placed in supercritical CO 2 In the reactor, turn off the CO 2 Vent valve, set reaction pressure to 12MPa, reaction temperature to 60°C, CO 2 Flow rate is 10mL / min, open CO 2 Cylinder valve, high-pressure pump and temperature control valve, make the pressure and temperature reach the set value, react for 30 minutes, other steps are the same as the corresponding embodiment, and prepare the composite porous scaffold material.

[0060] The morphology of the prepared composite porous scaffold material was characterized by Quanta200 environmental scanning electron microscope, the results are shown in figure 2 , and test its porosity according to the method in Example 1. The results show that some pores of the composite porous scaffold are interconnected, with an average pore diameter of 730 μm and a porosity of 83.6%.

Embodiment 3

[0062] In Example 1, the mold was placed in supercritical CO 2 In the reactor, turn off the CO 2 Vent valve, set reaction pressure to 12MPa, reaction temperature to 35°C, CO 2 Flow rate is 10mL / min, open CO 2 Cylinder valve, high-pressure pump and temperature control valve, make the pressure and temperature reach the set value, react for 30 minutes, other steps are the same as the corresponding embodiment, and prepare the composite porous scaffold material.

[0063] The morphology of the prepared composite porous scaffold material was characterized by Quanta200 environmental scanning electron microscope, the results are shown in image 3 , and test its porosity according to the method in Example 1. The results show that some pores of the composite porous scaffold are interconnected, with an average pore diameter of 300 μm and a porosity of 48.6%.

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Abstract

The invention relates to a composite porous support material prepared from the following raw materials in percentage by mass: 80%-95% of polylactic acid-glycollic acid copolymer, 2.5%-10% of hydroxylapatite and 2.5%-10% of collagen. The porosity of the composite porous support material is adjustable within the range of 45.2-97.4 percent, and the aperture is adjustable within the range of 45-1100 micrometers. According to the invention, the composite porous support material is prepared under the condition of supercritical CO2 through lower reaction pressure and shorter reaction time. Experimental results indicate that cells of a human osteosarcoma cell line MG-63 are adhered to the composite porous support material and have good proliferation status, the composite porous support material cannot cause obvious inflammatory reaction when implanted into the body of a rat, and various inflammatory factors are basically similar to blank groups at postoperative 28th day, and therefore the composite porous support material disclosed by the invention has good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of materials, in particular to a porous scaffold material and supercritical CO 2 Techniques for the preparation of porous scaffold materials. Background technique [0002] Scaffold materials for tissue engineering have become a research hotspot in the field of tissue engineering. The structure and performance of scaffold materials directly affect the repair and reconstruction of tissues and organs. In the field of tissue engineering, various scaffold materials have been used as templates for cell proliferation and differentiation. It is difficult for a single material to meet the needs of tissue engineering. Several medical biomaterials are compounded, and the overall performance of the material is adjusted through the difference in the content of each component, so that it has better biocompatibility. [0003] PLGA (poly lactate glycolic acid, polylactic acid-polyglycolic acid copolymer) is a degradable ...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/18A61L27/12
Inventor 张志琪牟朝丽王金磊祁小妮张婧
Owner SHAANXI NORMAL UNIV
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