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Thermally-stable hydroxyapatite whisker and preparation method thereof

A technology of hydroxyapatite and thermal stability, applied in chemical instruments and methods, single crystal growth, crystal growth, etc., can solve the problems of inability to strengthen and toughen matrix materials, and achieve easy operation, high thermal stability, and simple process Effect

Inactive Publication Date: 2011-11-23
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When used as the second phase material, it cannot strengthen and toughen the matrix material

Method used

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  • Thermally-stable hydroxyapatite whisker and preparation method thereof
  • Thermally-stable hydroxyapatite whisker and preparation method thereof
  • Thermally-stable hydroxyapatite whisker and preparation method thereof

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preparation example Construction

[0034] The preparation method of the thermally stable hydroxyapatite whisker according to the embodiment of the present invention comprises the following steps:

[0035] a) Provide α-TCP powder.

[0036] There is no special requirement for the α-TCP powder, for example, it may be a commercially available α-TCP powder, or α-TCP powder prepared by mixing and calcining may be used.

[0037] In some examples of the present invention, α-TCP powder is prepared through the following steps:

[0038] a-1) Calcium hydrogen phosphate (CaHPO 4 2H 2 O) and calcium carbonate (CaCO 3 ) in a molar ratio of 2:1 in deionized water or absolute ethanol medium for 12 to 48 hours to obtain a slurry.

[0039] The time for ball milling is not particularly limited, as long as it can be fully mixed, but in terms of mixing uniformity and cost, it is preferably ball milled for 12 to 48 hours, more preferably 24 to 48 hours.

[0040] a-2) Drying and pulverizing the slurry to obtain prefabricated powd...

Embodiment 1

[0070] First, measure 400ml of deionized water with a beaker, place it in a water bath at 70°C, and keep stirring.

[0071] Next, weigh 20 g of the α-TCP powder obtained above, slowly pour it into the above beaker, add ammonia water to adjust the pH to 10.5, and stir for half an hour to obtain a premix.

[0072] Thereafter, 0.20 g of KCl was added to the premixed liquid, and the stirring was continued for 24 hours to obtain a suspension.

[0073] After the suspension was precipitated and centrifuged, hydroxyapatite whiskers were obtained.

[0074] Finally, the above-mentioned hydroxyapatite whiskers were washed 3 times with deionized water, and then washed 3 times with alcohol, then suction filtered and dried.

[0075] The morphology of the washed and dried hydroxyapatite whiskers is as follows: figure 2 as shown in a.

[0076] In addition, in order to study the thermal stability of the treated HA whiskers, the HA whiskers were calcined at 1000 °C for 2 hours, and their mo...

Embodiment 2

[0079] First, measure 1000ml of deionized water with a beaker, place it in a water bath at 90°C, and keep stirring.

[0080] Next, weigh 10 g of the α-TCP powder obtained above, slowly pour it into the above beaker, add ammonia water to adjust the pH value to 11.5, and stir for half an hour to obtain a premix.

[0081] Thereafter, 0.82 g of KCl was added to the premixed liquid, and stirring was continued for 24 hours to obtain a suspension.

[0082] After the suspension was precipitated and centrifuged, hydroxyapatite whiskers were obtained.

[0083] Finally, the above-mentioned hydroxyapatite whiskers were washed 3 times with deionized water, and then washed 3 times with alcohol, then suction filtered and dried.

[0084] The morphology of the cleaned and dried hydroxyapatite whiskers and the morphology after calcination at 1000 °C for 2 hours were compared with those of figure 2 with image 3 similar.

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Abstract

The invention discloses a thermally-stable hydroxyapatite whisker and a preparation method thereof. The preparation method of the thermally-stable hydroxyapatite whisker comprises the following steps of: (a) providing alpha-TCP (Tertiary Calcium Phosphate) powder; (b) simultaneously stirring and adding the alpha-TCP powder in deionized water with the constant temperature of 70-90DEG C, adjusting the pH value to be 10.5-12.0 and continuously stirring for 10-30 minutes to obtain a premixing solution; (c) adding inorganic potassium salt in the premixing solution, wherein the mol ratio of potassium in the inorganic potassium salt to calcium in the alpha-TCP is (0.04-0.44):3, and continuously stirring for 12-50 hours to obtain a turbid liquid; and (d) carrying out solid-liquid separation on the turbid liquid to obtain the hydroxyapatite whisker. The hydroxyapatite whisker obtained by using the preparation method of the hermally-stable hydroxyapatite whisker, which is disclosed by the invention, has high thermal stability and can resist high temperature of 1000DEG C. In addition, the preparation method has the advantages of simple process and easiness for operation.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to a thermally stable hydroxyapatite whisker and a preparation method thereof. Background technique [0002] Calcium phosphate series bioceramic materials are widely used in bone defect repair, but their poor toughness affects their further application prospects. Adding whiskers can effectively improve the strength and toughness of ceramic materials. The whiskers involved in the current research include SiC whiskers, Si3N4 whiskers, etc. Although the addition of these whiskers can improve the toughness of bioceramics to a certain extent, it also greatly reduces the most important biocompatibility and bioactivity of the matrix material. However, hydroxyapatite whiskers have gradually attracted people's attention due to their biological properties close to those of the matrix material, and have been applied to the strengthening and toughening of bioceramic...

Claims

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Application Information

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IPC IPC(8): C30B29/14C30B29/62
Inventor 昝青峰王晨董利民李兆新田杰谟
Owner TSINGHUA UNIV
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