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A kind of solid lipid nanoparticle containing andrographolide and its preparation method and application

A technology of solid lipid nanometer and andrographolide, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, cardiovascular system diseases, etc., can solve the problems of no solid lipid nanoparticles, etc., to improve the degree of dispersion and Effects of bioavailability, increased targeting, and increased stability

Inactive Publication Date: 2011-12-14
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no relevant report on solid lipid nanoparticles containing andrographolide

Method used

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  • A kind of solid lipid nanoparticle containing andrographolide and its preparation method and application
  • A kind of solid lipid nanoparticle containing andrographolide and its preparation method and application
  • A kind of solid lipid nanoparticle containing andrographolide and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0046] 1) Take 45mg of andrographolide monomer, 250mg of glyceryl stearate, 250mg of glyceryl behenate, and 800mg of lecithin in a wedge-shaped bottle, add an appropriate amount of absolute ethanol, and dissolve it completely in a water bath at 80°C , the organic phase was obtained, the solvent was evaporated to dryness, cooled in an ice bath to form a solid, and set aside;

[0047] 2) Dissolve 1.5g Tween-80 in 50ml pure water to form a uniform water phase;

[0048] 3) mixing the solid prepared above with the water phase, stirring at a high speed of 10,000 rpm, so that the solid is uniformly dispersed to obtain colostrum;

[0049] 4) Perform high-pressure homogenization treatment with 60 MPa pressure at room temperature for 8 to 10 times, and then rapidly cool in an ice bath to obtain solid lipid nanoparticles containing andrographolide.

[0050] figure 1 For the particle size distribution figure of the prepared solid lipid nanoparticles containing andrographolide, by figur...

Embodiment 2

[0064] The solid lipid nanoparticles containing neoandrographolide monomer were prepared by the same method as in Example 1, wherein 45 mg of andrographolide monomer was replaced by 45 mg of neoandrographolide monomer.

[0065] It is determined that: the encapsulation efficiency of the solid lipid nanoparticles containing neoandrographolide monomer prepared in this embodiment is 91.2%, the drug loading is 3.52%, the average particle diameter is 256.4nm, and the average zeta potential is -19.8mv.

Embodiment 3

[0067] The same method as in Example 1 was used to prepare solid lipid nanoparticles containing dehydroandrographolide monomer, wherein 45 mg of andrographolide monomer was replaced by 45 mg of dehydroandrographolide monomer.

[0068] It is determined that: the encapsulation efficiency of the solid lipid nanoparticles containing dehydroandrographolide monomer prepared in this embodiment is 90.8%, the drug loading is 3.28%, the average particle diameter is 221.7nm, and the average zeta potential is -19.5mv.

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Abstract

The invention discloses a solid lipid nanoparticle containing andrographolide, a preparation method and application thereof. The solid lipid nanoparticle is composed of 1-20% andrographolide, 20-60% lipid material and 30-60% emulsifier. The preparation of described solid lipid nanoparticle comprises: adding andrographolide, lipid material and emulsifier in the organic solvent, heating makes to dissolve completely; The organic solvent is evaporated, is cooled with ice bath to form solid; Take Tween- Dissolve 80 in water to obtain the water phase; mix the obtained solid with the obtained water phase, and stir at high speed to disperse the solid uniformly to obtain colostrum; perform high-pressure homogenization treatment at room temperature, and then rapidly cool on an ice bath. The solid lipid nanoparticles containing andrographolide can be used in the form of a single form or a combination with a pharmaceutically acceptable drug carrier for the prevention and treatment of hyperlipidemia and / or atherosclerosis In the preparation of pharmaceutical preparations.

Description

technical field [0001] The invention relates to a solid lipid nanoparticle and its preparation method and application, in particular to a solid lipid nanoparticle containing andrographolide and its preparation method and application. Background technique [0002] Andrographolide (Andrographolide, AND) is a lactone compound extracted from Andrographis paniculata (Burm.f.) Nees, also known as Andrographis paniculata (Burm.f.) Nees, also known as Andrographolide B. One of the main active ingredients. There are a series of lactone compounds in Andrographis paniculata, mainly including: andrographolide 1, dehydroandrographolide 2, neoandrographolide 3 and deoxyandrographolide 4, etc., and its chemical structure is as follows: [0003] [0004] Andrographolide has antibacterial, antipyretic, cough and asthma effects, and is clinically used to treat upper respiratory tract inflammation and bacillary dysentery, with good curative effect and small side effects; it is used to trea...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/365A61K47/10A61K47/24A61K47/28A61K47/34A61K47/44A61P9/10A61P3/06
Inventor 王长虹王峥涛程雪梅杨涛盛欢欢
Owner SHANGHAI UNIV OF T C M
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