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Novel lactobacillus and its composition and its application in the preparation of drugs for improving diabetes and its complications

A technology of diabetes and composition, which is applied in the field of preparation of drugs for improving diabetes-related symptoms and its complications, and can solve the problems of no further improvement

Active Publication Date: 2011-12-14
GENMONT BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently published literature or patents about lactic acid bacteria improving diabetes are only limited to controlling blood sugar levels, body weight, blood lipid levels, and cholesterol levels.
For other possible complications of diabetes, such as inflammation in the body and decline in liver function, there is no further improvement

Method used

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  • Novel lactobacillus and its composition and its application in the preparation of drugs for improving diabetes and its complications
  • Novel lactobacillus and its composition and its application in the preparation of drugs for improving diabetes and its complications
  • Novel lactobacillus and its composition and its application in the preparation of drugs for improving diabetes and its complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1 bacterial strain is selected

[0062] The inventors of the present invention isolated more than one hundred isolates from the gastrointestinal tract specimens of healthy adults provided by the hospital to establish an isolate strain bank. Select three strains of Lactobacillus that can regulate the immune system to secrete high concentrations of IL-10 and IFN-γ from the strain bank, and select the top three Lactobacilli from the analysis results for the analysis of diabetic animal models. The deposit numbers, deposit dates and strain names of the three strains of Lactobacillus are shown in Table 1; among them, Lactobacillus reuteri (Lactobacillus reuteri) GMNL-89 is a public strain, and its strain characteristics, deposit certificate, and survival test report The originals of such certification documents and related information have been included in the patent application of the Republic of China (application number: 97115882; publication number: 200944215);...

Embodiment 2

[0062] The inventors of the present invention isolated more than one hundred isolates from the gastrointestinal tract specimens of healthy adults provided by the hospital to establish an isolate strain bank. Select three strains of Lactobacillus that can regulate the immune system to secrete high concentrations of IL-10 and IFN-γ from the strain bank, and select the top three Lactobacilli from the analysis results for the analysis of diabetic animal models. The deposit numbers, deposit dates and strain names of the three strains of Lactobacillus are shown in Table 1; among them, Lactobacillus reuteri (Lactobacillus reuteri) GMNL-89 is a public strain, and its strain characteristics, deposit certificate, and survival test report The originals of such certification documents and related information have been included in the patent application of the Republic of China (application number: 97115882; publication number: 200944215); wherein GMNL-205 and GMNL-263 are the newly isolate...

Embodiment 3

[0092] Example 3 Lactobacillus reuteri (Lactobacillus reuteri) GMNL-263

[0093] 3-1. Identification of the scientific name of Lactobacillus reuteri GMNL-263 strain

[0094] The isolate GMNL-263 was entrusted to the China Type Culture Collection Center for the identification of the bacterial scientific name, as follows:

[0095] Background information of isolate GMNL-263:

[0096] Isolation source: human gastrointestinal tract

[0097] Medium: MRS

[0098] Culture temperature: 37°C

[0099] Pathogenicity: none

[0100] see image 3 As shown in Table 4, the analysis results show that the isolate GMNL-263 is a Gram-positive bacillus without catalase, oxidase and motility, and can grow in both aerobic and anaerobic environments. In addition, the 16S rDNA partial sequence of the isolate GMNL-263 is shown in SEQ ID NO: 2. According to the 16S rDNA analysis, the isolate GMNL-263 is most similar to Lactobacillus reuteri, with a similarity of over 99%. Through API identificatio...

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Abstract

The invention discloses novel lactacidophilus, a composition thereof and use thereof in preparation of medicines for relieving diabetes mellitus and diabetic complications. The composition comprises at least one lactacidophilus which may be lactobacillus reuteri CMNL-89, lactobacillus gasseri GMNL-205 and lactobacillusreuteri CMNL-263. The lactobacillus gasseri GMNL-205 and the lactobacillusreuteri CMNL-263 are novel lactacidophilus. The composition or novel lactacidophilus can be used for relieving symptoms of diabetes mellitus and diabetic complications.

Description

technical field [0001] The invention relates to a novel lactobacillus and its composition, as well as the application of the novel lactobacillus and the composition in preparing medicines for improving diabetes-related symptoms and complications thereof. Background technique [0002] Diabetes mellitus (Diabetes Mellitus) is a metabolic disease with multiple etiologies. It is a disease caused by widespread metabolic disorders caused by defects in insulin secretion or action. Diabetes is a disease characterized by persistent chronic hyperglycemia, which can also cause metabolic disorders such as protein, fat, water, and electrolytes in the body. [0003] Diabetes is clinically divided into two main categories: [0004] Type 1: Insulin-dependent diabetic mellitus (IDDM), the general age of onset is mostly under 30 years old, so it was called "juvenile-onset diabetes" in the past, in fact, it can occur at any age. Type 1 diabetes is an autoimmune disease (Autoimmune Disease) i...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K36/064A23L1/30A23K1/16C12N1/20A61P3/10C12R1/225A23K10/18A23L33/135A61K35/747
Inventor 吕英震谢丰钦
Owner GENMONT BIOTECH
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