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A kind of photosensitizer and its preparation method and application

A photosensitizer and stabilizer technology, applied in the field of photosensitizers, can solve the problems of poor water solubility, limited range of use of F7, difficulties, etc., and achieve the effect of high encapsulation rate, uniform shape, and strong killing effect

Inactive Publication Date: 2011-12-21
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] F7 has extremely poor water solubility and is almost insoluble in water
This brings great difficulties to the route of administration, especially intravenous administration, and this defect greatly limits the scope of use of F7 in anticancer

Method used

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  • A kind of photosensitizer and its preparation method and application
  • A kind of photosensitizer and its preparation method and application
  • A kind of photosensitizer and its preparation method and application

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Experimental program
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Effect test

preparation example Construction

[0042] The method of preparation includes the following steps: after the proportion of the phospholipid, cholesterol, 酞 酞 zinc mat, and stabilizer is dissolved in organic solvents, the obtained solution is injected into the distilled water.-10: 1, stir while adding it while adding a decompression and evaporation under the temperature of 10-70 ° C to remove the THF, obtain the lipid system of the 酞 酞--, that is, the optical agent.

[0043] The particle size obtained by the preparation method is 50nm-5 microns.

[0044] The application is used by the photoresistic agent as an optical power therapy drug.

Embodiment 1

[0046] The raw materials of a photoresistic agent include α- (8-alcoholicine oxygen) single replacement of zinc, phospholipids, lipidized compounds, stabilizers, organic solvents and water.

[0047] The concentration of α- (8-oligraphy oxygen) to replace zinc zinc is 1.48 micro Mol / L, the concentration of phospholipids is 0.1g / L, the mass ratio of phospholipid and lipid-friendly compounds is 10: 1, stabilizer agent, and stabilizer agentThe mass concentration is 0.01%, and the volume ratio of the organic solvent is 1: 20-10: 1.

[0048] The phospholipids are selected from di -lipidized galloprotidine and di palmized gallotlin.

[0049] The lipid -intact compounds are selected from narcane and cholesterol.

[0050] The stabilizer is selected from the bib and right glycoside.

[0051] The organic solvent is selected from THF.

[0052] The method of preparation includes the following steps: after the proportion of phospholipid, cholesterol, α- (8-pyrine oxygen) is replaced by organic ...

Embodiment 2

[0054] The raw material of a third-generation photoresistic agent includes α- (8- (4,6-dioma-2-pyrine oxygen) -3, 6-epoxy-1-Cincin oxygen), Latalized compounds, stabilizers, organic solvents, and water, the volume ratio of organic solvent is 10: 1.

[0055] The α- (8- (4,6-dioma-2-pyrine oxygen) -3,6-epoxy-1-Cindyl) Moore concentration is 104.00 micromotone mol / L.The concentration of phospholipids is 10g / L, the mass ratio of phospholipids and lipid -friendly compounds is 1: 2, and the mass concentration of stabilizer is 2%.

[0056] The phospholipids are phospholipidyl glycerin.

[0057] The lipid -friendly compounds are C 12 -C 18 Direct connection saturated fatty acids.

[0058] The stabilizer is mannitol.

[0059] Organic solvent is selected from chloroform.

[0060] The method of preparation includes the following steps: phospholipid, cholesterol, α- (4, 6-two-based-2-pyrine oxygen) -3, 6-ethyte oxygenAfter dissolving organic solvents with organic solvents, the obtained soluti...

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Abstract

The invention relates to a photosensitizer and its preparation method and application. The photosensitizer is a liposome preparation composed of phthalocyanine zinc complex. The liposome preparation can be uniformly dispersed in an aqueous solution and exists stably for a long time, so it can be conveniently used as an injection drug, has high targeting, and can better exert drug effects. At the same time, the preparation has a wide range of killing and inhibiting effects on various types of bacteria, and has a strong killing effect on various cancer cells. item requirements.

Description

Technical field [0001] The present invention involves the field of biopharmaceuticals, and it also involves a photoresistic agent composed of 酞 菁 本 本. Background technique [0002] The liposome is formed by the lipid -like molecular layer. The internal closed sac balba of the water phase, the particle size ranges from dozens of nanometers to tens of microns.Liposy has a cell structure similar to the characteristics and functions of biofilms. It can wrap water -soluble and lipid -soluble drugs. Water -soluble drugs are wrapped in the internal water phase.As a pharmaceutical carrier, the release of the drug can be controlled, the targetedness of the drug is improved, the side effects of the drug toxicity are reduced, the use of biological utilization, and has a long -effect slow -release effect.In 1998, the lipid -based preparation, that is, the lipid gel "Pevary Lipogel" containing Yikongzazazole was registered in Cilag Pharmaceutical Company, Switzerland, and was sold in Switzerl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/127A61K47/24A61K47/28A61K47/34A61K47/36A61K31/4709A61K31/506A61K31/555A61P35/00
Inventor 薛金萍王立武刘宏方昱婷陈耐生黄金陵
Owner FUZHOU UNIV
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