Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of hyperbranched polyphosphoramidite and preparation method thereof

A technology of polyphosphoramidate and hyperbranched polymers, which is applied in the direction of pharmaceutical formulations and medical preparations of non-active ingredients, etc. It can solve the problems of limiting the application of phospholipid polymers and the inability of phospholipid bonds to be degraded by polymers.

Inactive Publication Date: 2011-12-28
XI AN JIAOTONG UNIV
View PDF1 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main chain of the current polyphosphoester synthetic polymers is a carbon-carbon bond, and the biodegradable phosphoester bonds are all in the side chains. The degradation of the phosphoester bonds cannot completely degrade the polymer, which greatly limits the high Applications of Molecules in Biomaterials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of hyperbranched polyphosphoramidite and preparation method thereof
  • A kind of hyperbranched polyphosphoramidite and preparation method thereof
  • A kind of hyperbranched polyphosphoramidite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028] Example 1: 0.1 mol of diisopropanolamine and 0.4 mol of triethylamine were dissolved in 50 mL of dichloromethane and 5 mL of DMF, and 0.15 mol of phenyl dichlorophosphate was added thereto under stirring. Reacted at 30°C for 24h, then warmed to 60°C and reacted at this temperature for 24h. After the reaction, the flask was cooled and washed with 2mol / L hydrochloric acid and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated to the minimum volume under reduced pressure, precipitated with dichloromethane-anhydrous ether three times, and dried in vacuo at 60°C for 24 hours to obtain a pale yellow viscous target polymer. The molecular weight of the product is 6500.

example 2

[0029] Example 2: 0.1 mol of dipropanolamine and 0.4 mol of triethylamine were dissolved in 50 mL of dichloromethane and 5 mL of DMF, and 0.15 mol of phenyl dichlorophosphate was added thereto under stirring. Reacted at room temperature for 24h, then warmed to 60°C and reacted at this temperature for 24h. After the reaction, the flask was cooled and washed with 2mol / L hydrochloric acid and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated to the minimum volume under reduced pressure, precipitated with dichloromethane-anhydrous ether three times, and dried in vacuo at 60°C for 24 hours to obtain a pale yellow viscous target polymer. The molecular weight of the product is 9500.

example 3

[0030] Example 3: 0.10 mol of dipropanolamine and 0.40 mol of N,N-dimethylaniline were dissolved in 20 mL of tetrahydrofuran and 50 mL of toluene, and 0.15 mol of methyl dichlorophosphate was added thereto under stirring. Reacted at 30°C for 24h, then warmed to 80°C and reacted at this temperature for 48h. After the reaction was completed, the flask was cooled, and the supernatant liquid was poured out. The residual substance was dissolved in chloroform and precipitated in anhydrous ether. The above solvent-precipitation process was repeated three times, and after filtration, washing, and vacuum drying, a white solid was obtained, which was the target polymer. The molecular weight of the product is 27600.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a hyperbranched polyphosphoramidate and a preparation method thereof. The preparation method of the hyperbranched polyphosphoramidate comprises that one or more B' B2 type hydramine monomers and one or more A2 type monomers selected from phenyl dichlorophosphate, isopropyl phosphonic dichloride, ethyl dichlorophosphite and the like are heated to undergo a reaction in the presence of at least one catalyst under a nitrogen protective atmosphere; reaction products are subjected to solution polymerization to form an AB2 type monomer; and the AB2 type monomer is subjected to further polycondensation to form the hyperbranched polyphosphoramidate. The hyperbranched polyphosphoramidate has the characteristics that a skeletal structure of the prepared hyperbranched polyphosphoramidate contains phosphatide bonds and phosphamide bonds and thus the hyperbranched polyphosphoramidate has good biodegradability; reaction raw materials of the hyperbranched polyphosphoramidate have wide sources; the reaction raw materials are commercial monomers; and the hyperbranched polyphosphoramidate is prepared by typical condensation polymerization. The preparation method has the advantages of mature synthesis way, simple reaction devices, operation and separation purification processes, and high product yield. Ends of molecular chains of the prepared hyperbranched polyphosphoramidate contain a lot of function groups and thus the prepared hyperbranched polyphosphoramidate can react with multiple active groups. The hyperbranched polyphosphoramidate has a wide application prospect especially in a biological material field.

Description

technical field [0001] The invention relates to a hyperbranched polymer, its preparation method and its application in biological materials. Background technique [0002] Currently, there are mainly liposomes, linear polymers and dendrimers as carriers of targeted drug delivery systems. Compared with traditional linear polymers, the dendritic structure has two advantages that make it used as a potential drug delivery carrier: one is that the drug molecules can be physically trapped inside the branched structure; the other is that the drug molecules are covalently bound On the surface or other groups of the hyperbranched-like structure, hyperbranched-drug conjugates are formed. However, the synthesis of dendrimers is complicated, the yield is low, the cost is high, and the application is limited. Different from dendrimers, hyperbranched polymers can be synthesized in one step, and have a three-dimensional highly branched structure and abundant functional groups at the end. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08G79/04A61K47/34
Inventor 刘育红李峰程平王彪
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com