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Pyridostigmine bromide odor masking dispersible tablets and preparation method thereof

A technology of pyridostigmine bromide and dispersible tablets, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., to achieve the effects of good taste, low energy consumption, and simple preparation process

Active Publication Date: 2013-08-14
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant research report on pyridostigmine bromide dispersible tablets in China

Method used

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  • Pyridostigmine bromide odor masking dispersible tablets and preparation method thereof
  • Pyridostigmine bromide odor masking dispersible tablets and preparation method thereof
  • Pyridostigmine bromide odor masking dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The weight composition ratio of each component contained in the prescription is:

[0029] 7.5 parts of pyridostigmine bromide

[0030] Cyclodextrin 15 parts

[0031] Compressible starch 37.5 parts

[0032] 20 parts microcrystalline cellulose

[0033] Anhydrous citric acid 7.5 parts

[0034] Sodium bicarbonate 7.5 parts

[0035] Aspartame 2.5 parts

[0036] Talcum powder 2.5 parts

[0037] The above-mentioned pyridostigmine bromide dispersible tablet novel preparation preparation method is as follows:

[0038] 1. Preparation of taste-masking powder: mix pyridostigmine bromide and cyclodextrin according to the above prescription, and grind in a ball mill at a speed of 60 rpm for 30 minutes, pour out, pass through a 100-mesh sieve, and set aside.

[0039] 2. Take the above-mentioned taste-masking powder, add the prescribed amount of compressible starch, microcrystalline cellulose, anhydrous citric acid, sodium bicarbonate, aspartame and talcum powder, sieve, mix eve...

Embodiment 2

[0041] The weight composition ratio of each component contained in the prescription is

[0042] 8 servings of pyridostigmine bromide

[0043] Cyclodextrin 32 parts

[0044] Lactose 30 parts

[0045] Low-substituted hydroxypropyl cellulose 10 parts

[0046] Cross-linked polyvinylpyrrolidone 10 parts

[0047] Citric acid 5 parts

[0048] Sodium carbonate 5 parts

[0049] 3 servings aspartame

[0050] Micronized silica gel 2 parts

[0051] The above-mentioned pyridostigmine bromide dispersible tablet novel preparation preparation method is as follows:

[0052] 1. Preparation of taste-masking powder: mix pyridostigmine bromide and cyclodextrin according to the above prescription, and grind in a ball mill at a speed of 60 rpm for 30 minutes, pour out, pass through a 100-mesh sieve, and set aside.

[0053] 2. Take the prescribed amount of lactose, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, citric acid, sodium carbonate, aspartame and taste-ma...

Embodiment 3

[0055] The weight composition ratio of each component contained in the prescription is

[0056] Pyridostigmine bromide 15 parts

[0057] Cyclodextrin 25 parts

[0058] Sorbitol 40 parts

[0059] 15 parts microcrystalline cellulose

[0060] Low-substituted hydroxypropyl cellulose 5 parts

[0061] Citric acid 10 parts

[0062] Sodium bicarbonate 8 parts

[0063] Acesulfame K 3 parts

[0064] 1 part talcum powder

[0065] The above-mentioned pyridostigmine bromide dispersible tablet novel preparation preparation method is as follows:

[0066] 1. Preparation of taste-masking powder: Preliminarily mix pyridostigmine bromide and cyclodextrin according to the above prescription, add distilled water twice the volume of cyclodextrin, stir well to make a uniform suspension, and grind in a colloid mill for 60 minutes , 60 ℃ dried to nearly dry when vacuum-dried to dry, crushed through a 100-mesh sieve, set aside.

[0067] 2. Take the prescribed amount of sorbitol, microcrystalli...

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Abstract

The invention provides pyridostigmine bromide odor masking dispersible tablets and a preparation method thereof. Each pyridostigmine bromide odor masking dispersible tablet comprises an effective dose of pyridostigmine bromide and pharmaceutical auxiliary materials, and is characterized by being prepared by performing odor masking treatment on the pyridostigmine bromide and mixing the pyridostigmine bromide and the pharmaceutically-acceptable auxiliary materials. The pyridostigmine bromide odor masking dispersible tablets obtained by the method do not have bitter taste, the disintegration time limit of a prescription is within 2 minutes, and the dissolution rate of the dispersible tablets within 45 minutes is more than 85 percent. The pyridostigmine bromide odor masking dispersible tablets have a simple and convenient preparation method, controllable quality, wide sources of an odor masking agent and low energy consumption and are easy to be produce industrially.

Description

technical field [0001] The invention relates to a novel preparation of pyridostigmine bromide, in particular to a dispersible tablet preparation of pyridostigmine bromide with quick release and good taste and a preparation method thereof Background technique [0002] Pyridostigmine Bromide (Pyridostigmine Bromide) is a cholinesterase inhibitor, which can reversibly bind to cholinesterase, inhibit the activity of cholinesterase, and cause endogenous acetylcholine to accumulate in the body, showing a muscarinic appearance In addition, it has a direct excitatory effect on the nicotinic choline receptors on the motor end plate, and can promote the release of acetylcholine from the motor nerve endings, thereby improving the gastrointestinal tract, bronchial smooth muscle and systemic bones. Muscle muscle tone, is a potent cholinesterase inhibitor. At present, pyridostigmine bromide is widely used in the treatment of myasthenia gravis. It is similar to neostigmine and has a sligh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/40A61K31/4425A61K9/20A61P21/04
Inventor 张景勍张梨
Owner CHONGQING MEDICAL UNIVERSITY