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Baohuoside I dry powder inhalant as well as preparation method and application thereof

A dry powder inhaler and dry powder inhaler technology, applied in the field of medicine, can solve problems such as no research reports, etc., and achieve the effects of good fluidity, good powder dispersion, and good lung deposition.

Inactive Publication Date: 2012-01-11
贾晓斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the research of baohuoside I dry powder inhalation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The baohuoside I was pulverized to D by airflow 90 = 3.2 microns, mixed with lactose having a particle size of 50-100 microns in a mass ratio of 1:6, after mixing evenly, the powder is packed into capsules or blisters or dry powder inhalers to obtain dry powder inhalers.

Embodiment 2

[0026] Mix baohuoside I and lactose in a mass ratio of 1:1, and use jet milling to D 90 =3.7 microns, the powder is packed into capsules or blisters or dry powder inhalers to obtain dry powder inhalers.

Embodiment 3

[0028] The baohuoside I was pulverized to D by airflow 90 = 3.5 µm, with D 90 Lactose = 2.7 microns and lactose with a particle size of 120-200 microns are mixed at a mass ratio of 1:1:7. After mixing evenly, the powder is packed into capsules or blisters or dry powder inhalers to obtain dry powder inhalers.

[0029] Study on Pulmonary Deposition Rate of Dry Powder Inhalation

[0030] According to the methods stipulated in the Pharmacopoeia of the People's Republic of China in 2010, the lung deposition rate of the preparation reached 26.52%. After being placed at room temperature for 24 months, the lung deposition rate of the preparation did not change significantly.

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Abstract

The invention relates to a Baohuoside I dry powder inhalant as well as a preparation method and application thereof. The inhalant provided by the invention is prepared from Baohuoside I utilized as an active substance and pharmaceutically acceptable auxiliary materials. Compared with oral administration, the dry powder inhalant developed according to the technical scheme provided by the invention has the advantage that the treatment effect of the Baohuoside I on tumors of lung is greatly improved.

Description

technical field [0001] The invention relates to a baohuoside I dry powder inhaler, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] In recent years, the research work of baohuoside I has attracted much attention at home and abroad, and it has shown good therapeutic value and application prospect in the prevention and treatment of lung cancer. However, due to the poor oral absorption and low bioavailability of baohuoside I, the efficacy of baohuoside I is limited, so far there is still no baohuoside I preparation on the market. [0003] Inhalants administered through the mouth have many advantages: drugs can quickly settle in the lungs after inhalation, can avoid or reduce toxic and side effects in other parts of the body, the lungs have a large absorption area, high membrane permeability, rich blood flow, and drug absorption It is rapid and has no liver first-pass effect, which is beneficial to impro...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K31/7048A61K47/34A61K47/26A61P11/00A61P35/00
Inventor 贾晓斌张振海孙娥宋捷
Owner 贾晓斌
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