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Multifunctional polyurethane medicament carrier as well as preparation method and application thereof

A polyurethane, multifunctional technology, applied in the field of new multifunctional polyurethane drug carrier and its preparation and application, can solve the problems of single function, lack of targeting ability, lack of responsiveness, etc. The effects of various control methods

Active Publication Date: 2013-12-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on degradable polyurethane in the field of drug carriers, and the function is single, lack of targeting ability, lack of responsiveness to environmental changes, etc. (CN 101503501B), and there is no multifunctional polyurethane nano drug delivery system. to report

Method used

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  • Multifunctional polyurethane medicament carrier as well as preparation method and application thereof
  • Multifunctional polyurethane medicament carrier as well as preparation method and application thereof
  • Multifunctional polyurethane medicament carrier as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Add the polymer diol (HPCL) and the comparison polymer diol (PCL) containing the stimuli-sensitive group and the hydrophobic segment into the reaction kettle equipped with a stirrer, a thermometer and a nitrogen protection device, stir and heat up to 60 ℃, vacuum drying for 120 minutes; then lower the temperature to 50 ℃, add aliphatic diisocyanate and solvent, raise the temperature to 60 ℃, prepolymerize for 120 minutes under stirring and nitrogen protection; then add 1‰ stannous octoate catalyst, comparative chain extension Agent (PDO), hydrophilic group-containing chain extender (GA12) and active group-containing chain extender (LGG), reacted for 150 minutes at 25-70°C; finally added the comparative end-capping agent (mPEG), and reacted After 120 minutes, the temperature was raised to 65° C., and the reaction was continued for 300 minutes. After the reaction solution is cooled, stop stirring and nitrogen protection, pour the reaction solution into an excess of ether ...

Embodiment 2

[0067]Add the polymer diol (HPCL) and the comparison polymer diol (PCL) containing the stimuli-sensitive group and the hydrophobic segment into the reaction kettle equipped with a stirrer, a thermometer and a nitrogen protection device, stir and heat up to 60 ℃, vacuum drying for 120 minutes; then lower the temperature to 50 ℃, add aliphatic diisocyanate and solvent, raise the temperature to 60 ℃, prepolymerize for 120 minutes under stirring and nitrogen protection; then add 1‰ stannous octoate catalyst, comparative chain extension Agent (PDO), hydrophilic group-containing chain extender (GA12) and active group-containing chain extender (LGG), reacted for 150 minutes at 25-70°C; finally added the contrast end-capping agent (mPEG) and containing Stimulate the capping agent (HPEG) of the sensitive group, react for 120 minutes, then raise the temperature to 65°C, and continue the reaction for 300 minutes. After the reaction solution is cooled, stop stirring and nitrogen protectio...

Embodiment 3

[0069] Add the polymer diol (HPCL) and the comparison polymer diol (PCL) containing the stimuli-sensitive group and the hydrophobic segment into the reaction kettle equipped with a stirrer, a thermometer and a nitrogen protection device, stir and heat up to 60 ℃, vacuum drying for 120 minutes; then lower the temperature to 50 ℃, add aliphatic diisocyanate and solvent, raise the temperature to 60 ℃, prepolymerize for 120 minutes under stirring and nitrogen protection; then add 1‰ stannous octoate catalyst, comparative chain extension Agent (PDO), hydrophilic group-containing chain extender (GA12) and active group-containing chain extender (LGG), react at 25-70°C for 150 minutes; finally add a capping agent containing a sensitive group (HPEG), the temperature was raised to 65° C. after 120 minutes of reaction, and the reaction was continued for 300 minutes. After the reaction solution is cooled, stop stirring and nitrogen protection, pour the reaction solution into an excess of ...

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Abstract

The invention provides a multifunctional polyurethane medicament carrier. The molecular structure of the multifunctional polyurethane medicament carrier comprises a biodegradable hydrophobic chain section, hydrophilic groups, stimulating and sensitive groups and active groups, and the weight-average molecular weight is 5000-100000. The polyurethane medicament carrier material can form a nano-scale self-assembly body in an aqueous solution so as to wrap an insoluble anti-tumor medicament; an ideal medicament administration system which has the multiple functions of long circulation, active targeting, stimulative responsibility, medicament controlled release and the like is formed on the surface of the carrier material through targeting molecules coupled with the active groups, thereby obviously improving the therapeutic effects of chemotherapeutic medicaments and expanding the therapeutic windows of high-efficiency toxic medicaments; and the multifunctional polyurethane medicament carrier provided by the invention has great application potential in the aspect of clinical treatment of cancers.

Description

technical field [0001] The invention belongs to the field of drug carrier materials, and in particular relates to a novel multifunctional polyurethane drug carrier and its preparation and application. Background technique [0002] Cancer is one of the leading causes of human death worldwide, and more than ten million new patients suffer from it every year (E.Blanco, C.W.Kessinger, B.D.Sumer and J.Gao, Experimental Biology and Medicine, 2009, 234, 123-131), the treatment methods mainly include surgical resection, radiotherapy and chemotherapy. Among them, chemotherapy is the main method for the treatment of tumors and certain immune diseases. At present, more than 90 chemotherapy drugs have been approved by the US Food and Drug Administration (FDA) for clinical use. However, most antineoplastic drugs are poor in water solubility and stability, resulting in problems such as low drug bioavailability, difficulty in administration, capillary embolism, significant individual diff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/48A61K47/34A61K45/00A61P35/00C08G18/65C08G18/66
Inventor 谭鸿丁明明傅强李洁华周立娟
Owner SICHUAN UNIV
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