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Method for detecting astragalus-chickpea particles

A detection method and particle technology, applied in the direction of particle and sedimentation analysis, measuring device, particle size analysis, etc., can solve the problems of unfavorable Qiying granule product quality stability, controllability, inconvenience, etc., achieve high accuracy, improve extraction High rate and good reproducibility

Inactive Publication Date: 2012-02-15
山西太行药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the original dosage form is a decoction, there are many inconveniences in the use of patients; according to the results of modern pharmacological research, the original prescription and technology were improved, and after modern technology extraction, a new Chinese medicine with definite clinical curative effect, safe use, and rapid onset of action was developed. ——Qiying Granules, used to treat diabetic peripheral neuropathy and other diseases
However, there is still no practical method that can conveniently and accurately detect the content of main raw materials in Qiying Granules in practice, which is not conducive to the stability and controllability of the product quality of Qiying Granules

Method used

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  • Method for detecting astragalus-chickpea particles
  • Method for detecting astragalus-chickpea particles
  • Method for detecting astragalus-chickpea particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Take an appropriate amount of Qiying granules, and test them by visual inspection, nose smell and mouth taste. This product is yellow-brown to brown granules with aroma, sweet taste and slightly bitter taste;

[0034] (2) Carry out particle detection on Qiying Granules. The particle detection includes the five items of solubility, particle size, moisture, loading difference and microbial limit. The test results should comply with the "Chinese Pharmacopoeia" 2010 Edition, Appendix I C Granules The provisions of the drug.

[0035] (3) Thin-layer chromatography identification method of Astragalus: Take Qiying granules, add ethanol, reflux for 30 minutes, filter, evaporate the filtrate to dryness, dissolve the residue with 0.3% sodium hydroxide solution, filter, adjust the pH to 5-6 with dilute hydrochloric acid, Shake and extract with ethyl acetate, separate the ethyl acetate solution, filter it with filter paper covered with an appropriate amount of anhydrous sodium s...

Embodiment 2

[0047] (1) Take an appropriate amount of Qiying granules, and test them by visual inspection, nose smell and mouth taste. This product is yellow-brown to brown granules with aroma, sweet taste and slightly bitter taste;

[0048] (2) Carry out particle detection on Qiying Granules. The particle detection includes the five items of solubility, particle size, moisture, loading difference and microbial limit. The test results should comply with the "Chinese Pharmacopoeia" 2010 Edition, Appendix I C Granules The provisions of the agent;

[0049] (3) Thin-layer chromatography identification method of Astragalus: Take Qiying granules, add ethanol, reflux for 30 minutes, filter, evaporate the filtrate to dryness, dissolve the residue with 0.3% sodium hydroxide solution, filter, adjust the pH to 5-6 with dilute hydrochloric acid, Shake and extract with ethyl acetate, separate the ethyl acetate solution, filter it with filter paper covered with an appropriate amount of anhydrous sodium ...

Embodiment 3

[0062] (1) Take an appropriate amount of Qiying granules, and test them by visual inspection, nose smell and mouth taste. This product is yellow-brown to brown granules with aroma, sweet taste and slightly bitter taste;

[0063] (2) Carry out particle detection on Qiying Granules. The particle detection includes the five items of solubility, particle size, moisture, loading difference and microbial limit. The test results should comply with the "Chinese Pharmacopoeia" 2010 Edition, Appendix I C Granules The provisions of the drug.

[0064] (3) Thin-layer chromatography identification method of Astragalus: Take Qiying granules, add ethanol, reflux for 30 minutes, filter, evaporate the filtrate to dryness, dissolve the residue with 0.3% sodium hydroxide solution, filter, adjust the pH to 5-6 with dilute hydrochloric acid, Shake and extract with ethyl acetate, separate the ethyl acetate solution, filter it with filter paper covered with an appropriate amount of anhydrous sodium s...

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Abstract

The invention relates to a method for detecting astragalus-chickpea particles. Raw materials of the astragalus-chickpea particles mainly comprise astragalus, red-rooted salvia root, sealwort, chickpea, cicada shell and lactose. The detection method comprises content measurement: measuring the content of astragalus and red-rooted salvia root in the particles with a high performance liquid chromatography method, wherein every bag of astragalus-chickpea particles contains not less than 35.0 mg of red-rooted salvia root counted by danshinolic acid BC36H30016 and not less than 1.0 mg of astragalus counted by astragaloside A C41H68014. The detection method can further comprise thin layer chromatography, character detection and particle detection. By establishing a detection method with high accuracy, high repeatability and high stability, the weight of the astragalus-chickpea particles can be controlled effectively, and the quality of the astragalus-chickpea particles is stable, controllable, efficient and safe.

Description

technical field [0001] The invention relates to a detection method in the field of traditional Chinese medicines, in particular to a detection method for the contents of astragalus and salvia miltiorrhiza in Qiying granules. Background technique [0002] Qiying Granule is an oral preparation developed on the basis of Luobitong, a decoction commonly used in clinical practice in the Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University. The original prescription is derived from summarizing the theoretical discussion on diabetes and its complications, the records of prescriptions and medicines, and the characteristics of local medicines in Xinjiang, combined with modern pharmacological research and formulating prescriptions, which have been clinically used by experienced physicians for more than ten years. The efficacy of the original prescription is to nourish qi and nourish yin, promote blood circulation and remove blood stasis, detoxify and reduc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/90G01N15/02
Inventor 李林葆张卫兵胡晓灵
Owner 山西太行药业股份有限公司
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