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Eye drops for treating cataract

A technology for eye drops and cataracts, which is used in medical preparations containing active ingredients, drug delivery, ether/acetal active ingredients, etc. , the effect of enhancing the suppression performance

Inactive Publication Date: 2012-03-28
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But, the present inventor finds that the effect of both of the above-mentioned (I) formula and (II) formula compounds is not very satisfactory when they are used alone.

Method used

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  • Eye drops for treating cataract
  • Eye drops for treating cataract
  • Eye drops for treating cataract

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] Example 1 (preparation of dendrobium phenol)

[0017] Dendrobium phenol extraction method is the prior art, the inventor refers to the literature (Zhang Chaofeng, Shao Li, Wang Lei, etc. Research on the chemical constituents of Dendrobium phenolic species [J]. Chinese Journal of Traditional Chinese Medicine, 2008, 33 (24): 2922-2925 .Yang Li, Gu Lihua, Wang Zhengtao, et al. Qualitative and quantitative analysis of bibenzyl compounds in Dendrobium sheath [J]. Chinese Journal of Pharmaceutical Sciences, 2007, 42(21): 1620~1623.) report on the preparation of dendrobium , the specific implementation process is as follows:

[0018] Dried Dendrobium nobile, chopped into coarse powder, heated and refluxed with 95% ethanol to extract 2 to 3 times, the amount of ethanol added each time was 12000ml / kg of medicinal material, refluxed for about 2 hours, combined with the medicinal liquid, suction filtered, and the filtrate was concentrated to There is no ethanol smell, and the ext...

example 2

[0021] Example 2 (preparation of syringic acid)

[0022] The syringic acid extraction method is also a prior art, and the inventor refers to the literature [Zhang Xue, Gao Hao, Wang Naili, etc. Phenolic components in Dendrobium nobile [J]. Chinese Herbal Medicine, 2006, 37(5): 652-655. Zhang Xue1, Xu Jiekun, Wang Naili, et al. Antioxidant activity of bibenzyls and phenolic acids in Dendrobium nobile [J]. Chinese Journal of Pharmaceutical Sciences, 2008, 43(11): 829-832. Shao Li, Huang Weihua, Zhang Chaofeng, et al. Chemistry of Dendrobium nobile Composition Research. Chinese Journal of Traditional Chinese Medicine, 33 (14): 1693-1695.] reported the preparation of syringic acid. The specific implementation process is as follows:

[0023]5 kg of dried stems of Dendrobium nobile were heated and refluxed twice with 10 times the volume fraction of 60% ethanol for 2 hours each time, the extracts were combined, the solvent was recovered under reduced pressure, and the extract was ...

example 3

[0025] Example 3 (eye drops of the present invention)

[0026] (1) Prescription:

[0027] Dendrobium phenol 1.00g, syringic acid 1.25g, carmellose sodium 2.1g, ethyl p-hydroxybenzoate 0.31g, sodium chloride 9.8g.

[0028] (2) Preparation method:

[0029] Dissolve carmellose sodium in an appropriate amount of water for injection, let it dissolve overnight, filter it with a Buchner funnel pad with 200-mesh nylon cloth, and set aside; add ethyl p-hydroxybenzoate to a small amount of water for injection, heat to dissolve, set aside Add sodium chloride to an appropriate amount of water for injection, heat to dissolve, and set aside;

[0030] Get carmellose sodium and place it on a water bath to heat and boil, add dendrobium phenol and syringic acid under stirring, add the prepared ethyl p-hydroxybenzoate solution and sodium chloride solution after stirring evenly, add water for injection to 1000ml, fully Stir evenly; use a 200-mesh nylon cloth pad to filter under reduced pressur...

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Abstract

The invention relates to a medical preparation containing organic effective components, in particular to eye drops for treating cataract. The eye drops are water solution and are characterized by containing 2.25g / 1000ml-3g / 1000ml effective components, wherein the effective components consist of 3',4-dihydroxy-3,5'-dimethoxy bibenzyl and 3,5-dimethoxy-4-hydroxybenzoic acid, with the mass ratio of 1:0.2-5. The eye drops for treating cataract has significant treatment effect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing organic active ingredients, in particular to a pharmaceutical preparation containing phenolic organic active ingredients. Background technique [0002] Cataract is an eye disease with the highest morbidity and blindness rate in the world. There is no unified understanding of the pathogenic mechanism of cataract, but it is believed that cataract is closely related to lens protein degeneration. Treatments for cataracts include medication and surgery. Surgical treatment has certain risks. First, post-operative wound repair, residual lens epithelial cells (LEC) will rebound and proliferate and migrate, which will form cataract again, that is, "secondary cataract". More and more cataract patients belong to the early stage of development. Or waiting for surgery or the category of unsuccessful surgery; second, some elderly patients are often accompanied by other diseases such as diabetes, hype...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/09A61K9/08A61P27/12
Inventor 魏小勇
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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