N-(2-(substituted benzo- thiazole-2- amino formacyl) -phenyl group) - benzamide, as well as preparation method and usages thereof

Abstract

The invention discloses N-(2-(substituted benzo- thiazole -2- amino formacyl) -phenyl group) - benzamide with an effect of plant virus resistance, and a preparation method thereof. The chemical structure is expressed by a general formula (1). The invention introduces a benzothiazole ring benzoyl aminobenzene methanamide compound containing substituted benzoic acid, which adopts raw materials of substituted benzoic acid, substituted anthranllic acid, substituted benzothiazole amine, thionyl chloride and acetic oxide and is synthesized through four steps of chlorination, acidylation, cyclization and ring opening, and the compound has plant virus resisting activity and anticancer activity.

Description

technical field [0001] The invention relates to the synthesis and preparation method of benzothiazole ring-containing o-benzamidobenzamide compounds with anti-plant virus effect. Background technique [0002] The o-benzamidobenzamide compounds are a class of ryanodine receptor analogs with good biological activity, and the structural modification of the ryanodine receptor as the parent has opened up a new field for the creation of new pesticides. At present, several commercialized products have appeared, such as flubendiamide and chlorantraniliprole, two broad-spectrum synthetic insecticides with ryanodine receptor structures discovered by Nippon Pesticides, Bayer and DuPont. The o-benzoylaminobenzamide compound has the same action characteristics as ryanodine, not only has excellent insecticidal activity against pests, but also is safe for mammals. [0003] 2005 Lahm et al (Lahm, G.P.; Selby, T.P.; Freudenberger, J.H.; Stevenson, T.M.; Myers, B.J.; Seburyamo, G.; Smith, B....

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Problems solved by technology

[0013] In 2002, El-Gaby et al. (El-Gaby, M.A.; Micky, J.; Tahol, N.Antimicrobial activity of some novel thiourea, hydrazine, fused pyrimidine and 2-(4-substituted)aniline benzoazole derivatives containing sulfonamide moieties[J ].Journal of Chinese Chemical Society, 2002,49,407-414.) synthesized the isothiocyanate containing benzenesulfonamide with 4-aminobenzenesulfonamide and thiophosgene reaction, this isothiocyanate is again Reflux with N,N-dimethylformamide and triethylamine for several hours to synthesize benzobenzothiazole derivatives with fungicidal activity, and use the growth rate method to test the fungicidal activity of this type of compound. The activity test shows that : At the concentration of 1.0mg / ml, this type of compound has higher inhibitory activity to Proteus; wherein one compound has moderate inhibitory activity to Staphylococcus aureus (Staphylococcus aureus) and penicillium (Penicillium); Inhibitory activity of Prodigobacterium and Aspergillus was weak

[0015] It can be seen from the background technology that bisamide compounds such as chlorantraniliprole have good insecticidal activity and are safe to mammals, and benzothiazole compounds such as benthiazil have good antibacterial activity and have excellent effect on rice sheath blight. However, no one has synthesized bisamide compounds containing benzothiazole-containing pyrazole amide, and no one has studied the use of benzothiazole-containing pyrazole amide bisamide compounds in plant viruses

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