Design and preparation of iodine antibacterial hydroxyapatite coating titanium and titanium alloy implants
A technology of hydroxyapatite and titanium alloy, applied in the field of medical biomaterial preparation, can solve the problems of restricting clinical research and use, increasing production cost and production cycle, poor physical and chemical properties of coatings, etc.
Inactive Publication Date: 2012-04-18
周君琳
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Problems solved by technology
However, at present, the only suitable method for industrialized production of hydroxyapatite coatings is the plasma spraying process. The physical and chemical properties of the coatings produced by other methods are relatively poor, and the production process is complicated, which increases the production cost and production cycle, and limits clinical application. research and use
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[0015] 1. Surface pretreatment of plants in titanium and titanium alloy substrates: cleaning and sandblasting pretreatment.
[0016] 2. Preparation of hydroxyapatite and povidone-iodine mixed powder Weigh hydroxyapatite powder and povidone-iodine powder according to a certain ratio, and ball mill and dry mix for 2 hours to prepare mixed powder with iodine content of 1-3 wt%.
[0017] 3. Using a vacuum plasma spraying process, the mixed powder is deposited on the titanium and titanium alloy metal substrates according to the following parameters (Table 1).
[0018] Table 1 Spraying parameters
[0019]
[0020]
[0021] slpm: standard liters per minute
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The invention relates to a design, a preparation and an application of iodine antibacterial hydroxyapatite coating metal implants. The metal implants comprise pure titanium or a titanium alloy matrix and an iodine antibacterial hydroxyapatite coating which comprises hydroxyapatite and povidone iodine particles, wherein iodine is used as an antibacterial additive, and the mass percentage of iodine in the composite coating is 1-3%. The matrix which is pretreated is subjected to a vacuum plasma spraying technology to prepare the composite coating. The composite coating which has the bone ingrowth characteristic of prosthese surface hydroxyapatite and has the antibacterial performance of iodine has a good biocompatibility, a good biomechanical performance and an antibacterial performance, can control the infection and the loosening related with the implants of prosthese and the like, and simultaneously avoids the toxic side effect caused by the whole body antibiotic application and possible adverse events of the drug resistance and the like caused by the local antibiotic application. A titanium alloy femoral joint prosthese example of the hydroxyapatite composite coating containing 2wt% of iodine is shown in Fig. 1. The inhibition rate of hydroxyapatite coatings of different iodine contents to escherichia coli, Bacillus pyocyaneus and staphylococcus aureus is shown in Fig. 2.
Description
[0001] Technical field The present invention relates to the design, preparation and application of an iodine antibacterial hydroxyapatite composite coating metal implant, which belongs to the technical field of medical biomaterial preparation. Background technique [0002] Hydroxyapatite (HA) is a typical bioactive material. When it is implanted into the human body, it can not only guide bone formation, but also form osseointegration with new bone without inflammation or irritation. Therefore, it is often used as artificial bone, artificial joint, artificial tooth root and bone filling material. Although hydroxyapatite has good biological activity and compatibility, its mechanical properties are still insufficient and it is difficult to meet medical requirements. The corrosion resistance, biocompatibility, bone fusion, mechanical properties, and machinability of titanium and titanium alloys all meet the requirements of biological materials, and solve the defects of low strengt...
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Login to View More IPC IPC(8): C09D1/00C09D7/12C23C4/12C23C4/04C23C4/134
Inventor 周君琳
Owner 周君琳