Solid-liquid separation method of salinomycin fermentation liquor

Abstract

The invention discloses a solid-liquid separation method of salinomycin fermentation liquor. The method comprises the following steps of: firstly, raising the temperature of the salinomycin fermentation liquor to 55 to 65 DEG C by heating; during stirring, adding 30 percent of caustic soda liquid of an ionic membrane to adjust a potential of hydrogen (pH) value to 10.0 to 11.0; adding concentrated sulfuric acid to adjust the pH value to 7.0 to 8.0; adding calcium carbonate with 3 volume percent of fermentation liquor and sodium silicate with 6 volume percent of fermentation liquor; stirring for 2 hours to obtain salinomycin bacteria grout; and under the squeezing pressure of 1.6 MPa, performing membrane filter pressing on the salinomycin bacteria grout to obtain a salinomycin filter cake solid. With the characteristic that the salinomycin fermentation liquor is subjected to alkaline hydrolysis and then subjected to solid-liquid separation by using a plate frame, a salinomycin filter cake having lower water content is produced. The solid-liquid separation method of the salinomycin fermentation liquor has the advantages of high solid-liquid separation yield, low concentration of a chemical oxygen demand (COD) in waste liquor, low water content of the filter cake, and low production cost; and the cost of environmental protection is reduced.

Description

technical field [0001] The invention relates to a method for solid-liquid separation of salinomycin fermentation liquid, which is a method for solid-liquid separation of salinomycin fermentation liquid by plate and frame filter press technology after alkaline hydrolysis. Background technique [0002] The active ingredient of salinomycin premix is ​​salinomycin, and the molecular formula of salinomycin is C 42 h 70 o 11 , with a molecular weight of 751.0. Since salinomycin is a polyether monocarboxylic acid antibiotic, it can strongly bind to alkali metal ions in cells, especially potassium, sodium, and rubidium ions, and enhance the ability of cations necessary for biology to pass through the lipid barrier on the cell membrane. Soakability, inhibits the normal ion balance of sporozoites and schizonts, thereby killing coccidia. Therefore, this product has a high susceptibility to Gram-positive bacteria, fungi, viruses and malaria parasites. As an antiprotozoal drug, it i...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for solid-liquid separation of salinomycin fermentation liquid, which is characterized by alkaline hydrolysis and pressure filtration of the fermentation liquid, and solves the problems of low solid-liquid separation yield and high energy consumption for drying in the acidification treatment. A production technology that is more economical, environmentally friendly and suitable for industrial production