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Method for preparing monodispersed functional polymer microspheres

A functional polymer and monodisperse technology, which is applied in the field of preparing monodisperse functional polymer microspheres, can solve problems such as industrial application limitations, and achieve the effect of good monodispersity and simple and easy method

Inactive Publication Date: 2012-05-02
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these unconventional suspension polymerization methods have high requirements on the reactor structure, so the industrial application is limited

Method used

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  • Method for preparing monodispersed functional polymer microspheres
  • Method for preparing monodispersed functional polymer microspheres
  • Method for preparing monodispersed functional polymer microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Continuous water phase preparation: In a 250ml three-neck flask with a jacket, add 2.8g polyvinyl alcohol, 1.0g gelatin, 2.0g sodium chloride, 10.0g sucrose and 184.2g distilled water respectively, connect mechanical stirring and Condensate water, heat to 90°C while stirring, control the stirring speed until the polyvinyl alcohol is completely dissolved, and let the solution stand for later use.

[0024] (2) Pre-polymerization: Install a 250ml three-neck bottle with a jacket in an ultrasonic cleaner, add 5.3ml glycidyl methacrylate (GMA), 4.8ml hydroxyethyl methacrylate (HEMA), 3.05ml ethylene glycol Alcohol dimethacrylate (EGDMA), 6.6ml butyl acetate, 6.6ml n-octane, 0.065g azobisisobutyronitrile (AIBN), ultrasonic treatment for 5 min; The jacket was heated to 75°C and reacted for 0.5h.

[0025] (3) Ultrasonic-assisted dispersion: Take 132ml of the continuous water phase prepared in step (1), add it to the pre-polymerization liquid in step (2), adjust the stirring...

Embodiment 2

[0029] (1) Continuous water phase preparation: In a 250ml three-necked flask with a jacket, add 2.0g polyvinyl alcohol, 2.0g gelatin, 3.0g sodium chloride, 6.0g sucrose, and 187.0g distilled water respectively, connect mechanical stirring and condensation water, heated up to 90°C while stirring, controlled the stirring speed until the polyvinyl alcohol was completely dissolved, and the solution was left standing for later use.

[0030] (2) Pre-polymerization: Install a 250ml three-neck bottle with a jacket in an ultrasonic cleaner, add 5.3ml glycidyl methacrylate (GMA), 4.8ml hydroxyethyl methacrylate (HEMA), 3.05ml ethylene glycol Alcohol dimethacrylate (EGDMA), 6.6ml butyl acetate, 6.6ml n-octane, 0.065g azobisisobutyronitrile (AIBN), ultrasonic treatment for 5 min; The jacket was heated to 71°C and reacted for 1.0h.

[0031] (3) Ultrasonic-assisted dispersion: Take 105ml of the continuous water phase prepared in step (1), add it to the pre-polymerization liquid in step (2)...

Embodiment 3

[0035] (1) Continuous water phase preparation: In a 250ml three-necked flask with a jacket, add 2.0g polyvinyl alcohol, 2.0g gelatin, 2.0g sodium chloride, 10.0 sucrose, 184.0g distilled water, connect mechanical stirring and condensate , heated to 90°C while stirring, controlled the stirring speed until the polyvinyl alcohol was completely dissolved, and the solution was left standing for later use.

[0036](2) Pre-polymerization: Install a 250ml three-neck bottle with a jacket in an ultrasonic cleaner, add 5.3ml glycidyl methacrylate (GMA), 4.8ml hydroxyethyl methacrylate (HEMA), 3.05ml ethylene glycol Alcohol dimethacrylate (EGDMA), 6.6ml butyl acetate, 6.6ml n-octane, 0.102g azobisisobutyronitrile (AIBN), ultrasonic treatment for 5min; connect mechanical stirring and condensate water, stir slowly while clamping Heat the jacket to 71°C and react for 1.5h

[0037] (3) Ultrasonic-assisted dispersion: Take 132ml of the continuous water phase prepared in step (1), add it to th...

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Abstract

The invention discloses a method for preparing monodispersed functional polymer microspheres, comprising the following steps: dispersing a partial polymerized oil phase with the aid of ultrasonic into a continuous water phase to prepare a suspension, heating up to 80-85 DEG C, and preparing polymer microspheres by using a traditional suspension polymerization method, wherein, the oil phase comprises glycidyl methacrylate and hydroxyethyl methacrylate as functional monomers, ethylene glycol dimethacrylate as a cross-linking agent, a hydrophobic porogenic agent, and an oil soluble initiator, and the water phase comprises a stabilizing agent, a co-stabilizer, and soluble inorganic salt. The method is easy to practice and has no special requirements of reactor structure. The prepared monodispersed functional polymer microspheres have good monodispersity. According to the invention, because of the presence of functional groups consisting of epoxy group and hydroxyl group, a special functional resin can be obtained after chemical modification. The invention can be applied in medicine, selective absorption, immobilized enzyme, and large biological molecule separation and purification and related fields.

Description

technical field [0001] The invention relates to an improved suspension polymerization method for synthesizing monodisperse functional polymer microspheres, in particular to ultrasonic-assisted suspension polymerization for preparing functionalized polymer microspheres. Background technique [0002] Monodisperse functional polymer microspheres have broad application prospects in high-tech fields such as biochemistry, immunomedicine, immobilized enzymes, high-efficiency ion exchange resins, solid-phase synthesis carriers, and chromatographic packing. At present, the main methods for synthesizing monodisperse polymer microspheres include emulsion polymerization, dispersion polymerization, precipitation polymerization, seed swelling polymerization and glass membrane emulsification method (SPG). [0003] Emulsion polymerization techniques, such as microemulsion polymerization and soap-free emulsion polymerization, are usually used to prepare monodisperse polymer microspheres with...

Claims

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Application Information

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IPC IPC(8): C08F220/32C08F220/28C08F222/14C08F2/18
Inventor 朱宏吉胡宗福张华陆帅乔建军
Owner TIANJIN UNIV
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