76results about How to "Small dispersion coefficient" patented technology

The invention belongs to the field of pharmaceutical agents, relates to a polymer micelle lyophilized agent encapsulating an insoluble antitumor drug as well as a preparation method and an application thereof. The polymer micelle lyophilized agent is prepared by carrying out molecular self-assembly on a methoxy poly(ethylene glycol) 2000-polyester block copolymer to form micelles, and then encapsulating the insoluble antitumor drug in a hydrophobic core formed by the polyester. The lyophilized agent has high encapsulation rate, high drug loading and small particle size, can significantly improve the water solubility of the insoluble drug and result in passive targeting of more antitumor drugs to concentrate in the tumor tissues, thus improving an anti-tumor treatment effect and reducing the toxic and side effects of drugs, and can be used to prepare the drugs used for the treatment of lung cancer, intestinal cancer, mammary cancer, ovarian cancer, etc. The lyophilized agent can also be quickly dissolved and dispersed to form a transparent micellar solution after water for injection, normal saline solution and the like are added, and is used for the preparation of the drugs for treating primary intestinal cell carcinoma.

The invention relates to the field of fatigue load spectrum compilation, in particular to an accelerated fatigue load spectrum compilation method. The method includes: taking a fleet overload nz-cumulative transcendental N curve family as a data source, performing compiling to obtain a corresponding stand-alone spectrum; calculating, counting and analyzing cluster load spectrum damage; and performing deducing to obtain cluster life distribution, determining the damage of the accelerated fatigue load spectrum by taking meeting the cluster life reliability requirement as a principle, determiningan overload-accumulated transcendental curve corresponding to the accelerated fatigue load spectrum through statistical analysis of a cluster nz-N curve, and further performing compiling to obtain the accelerated fatigue load spectrum. The spectrum considers the dispersion of the cluster load spectrum and the structural characteristics, and only needs to consider the dispersion of the structuralcharacteristics by reasonably weighting the damage of the load spectrum, and the dispersion coefficient value is obviously smaller than the dispersion coefficient under the average spectrum, so that the fatigue test time can be shortened exponentially, and the purpose of fatigue acceleration is achieved.

The invention relates to a device and method for producing low-dispersion coefficient carbon fibers. The device and method mainly solve the technical problem that the existing method and device produce carbon fibers with a large mechanical property dispersion coefficient and poor stability. Through use of processes such as drawing (2) in saturated steam and drying (3) after precursor fiber uncoiling (2) and before pre-oxidation (4), low temperature carbonization (5), high temperature carbonization (6), surface treatment, starching and drying (7) and rolling (8) and use of a roller linear speed of transmission systems before and after each one of processes, a fiber tension force is adjusted and controlled. Through the device and method, the polyacrylonitrile precursor has the largest orientation degree before pre-oxidation so that the fibers are more homogenized in later treatment. The device and method effectively reduce a carbon fiber mechanical parameter such as a dispersion coefficient, well solve the above problem and can be used in the field of carbon fiber industrial production.

The invention discloses a liquefaction method of lignin for preparing a thermoplastic phenolic resin. The liquefaction method is as follows: mixing phenol, a heteropoly acid catalyst and enzymatic hydrolysis lignin, heating to 90-160 DEG C, and liquefying for 1-3 h to obtain a liquefied product. The invention provides an efficient method for preparing a phenolic compound used for substituting phenol by using enzymolysis lignin in abundant resource, and the method uses the a green heteropoly acid catalyst, which has no pollution to the environment. The enzymolysis lignin liquefaction product obtained by the invention can be used in the preparation of a lignin base thermoplastic phenolic resin.

The invention relates to weather-resisting type single-coating powder paint with metal pattern effect. The weather-resisting type single-coating powder paint comprises bottom powder A and metal powder B; the bottom powder A is prepared from the following components in percentage by weight: 55 percent to 80 percent of weather-resisting type polyester resin, 4.0 percent to 6.2 percent of a curing agent, 0 to 40 percent of modified barium sulfate, 0.3 percent to 1.5 percent of a plasticizer, 0.02 percent to 2 percent of a curing accelerator, 1 percent to 5 percent of an auxiliary agent, 0 to 25 percent of pigment and 0.05 percent to 0.5 percent of a texturizing agent; the weather-resisting type polyester resin is synthesized from the following raw materials: neopentyl glycol, butylene glycol, 2-methyl-1,3-propylene glycol, cyclohexanedimethanol, 2-butyl-2-ethyl-propylene glycol, terephthalic acid and the like. By adopting modified polyester, the weather-resisting type single-coating powder paint with metal pattern effect has excellent weather resistance and also has a three-dimensional pattern effect; the weather-resisting type single-coating powder paint with metal pattern effect can be thickly applied and a thickly coated film with the thickness of 60UM to 120UM is formed by coating in one step; the coated film only needs to be cured for one time; the weather-resisting type single-coating powder paint with metal pattern effect has the characteristics of 10-year weather resistance, high metal stereoscopic impression, clear pattern effect, good coverage, good mechanical property, low cost, no pollution to the environment and the like.

The invention relates to a manufacture method for a leather cup for sealing a high-speed rotation shaft. The leather cup is made of FX-4 fluorous rubber. The method comprises the following steps that the direct molding pressing forming is adopted, and then, the subsequent treatment of primary vulcanization, secondary vulcanization and mechanical processing treatment on lips are carried out. The manufacture method is characterized in that before the leather cup manufacture through the direct molding pressing forming, a metal inner framework firstly needs the glue coating treatment, the process has the technical requirements that 2# binding agents are coated on the metal inner framework, the drying is carried out for 30 to 40 minutes at the room temperate, then, 1# binding agents are coated, then, the room-temperature drying and the high-temperature drying are carried out, the glue coating thickness in each time is 0.1 to 0.2mm, the 2# binding agents are FXY-4, the 1# binding agents are FXY-7, the room-temperature drying requires the temperature being 23 to 30 DEG C and the drying time being 20 to 30 minutes, and the high-temperature drying has the concrete requirements of the temperature being 120 to 143 DEG C and the drying time being 30 to 60 minutes. In the manufacture method, the aspects such as metal inner framework binding and the like are greatly improved, and a good technical effect is correspondingly realized.

The invention relates to a fibre spinning method for a polyacrylonitrile solution, and mainly solves the technical problems in the prior art that a fibre spinning assembly has poor sealing property, fiber spinning pressure is high, and coagulating bath nascent fibre breakage is more. The invention adopts the technical scheme that the fibre spinning method for the polyacrylonitrile solution comprises the following steps: for a polyacrylonitrile/dimethyl sulfoxide solution with the molecular weight of 80 thousands to 200 thousands and viscosity of 60Pa.s to 120Pa.s, adopting an embedded fibre spinning assembly, filtering by a multi-layer combined filter net, distributing by a distributing plate, extruding by a spinneret plate, entering a coagulating bath, and coagulating to form coagulated filaments. The problems are better solved, and the fibre spinning method can be used in industrial production of polyacrylonitrile-based carbon fiber protofilaments.

The invention belongs to the field of medicinal preparations, and particularly relates to a docetaxel compound liposome, a preparation method thereof and an application of the liposome. The docetaxel compound liposome comprises docetaxel, pentacyclic triterpene compounds, phospholipid and cholesterol, the weight ratio of the docetaxel to the pentacyclic triterpene compounds is 1:(1-200), and preferably, the pentacyclic triterpene compounds are ursolic acid. Preferably, the preparation method of the docetaxel compound liposome is an ethanol injection method. The docetaxel compound liposome overcomes a lyophobic shortcoming of the liposome, anti-cancer effect can be enhanced through synergistic effect, and toxic and side effects of the docetaxel are relieved.

The invention relates to a sample preparation method for testing mechanical properties of high-thermal-conductivity mesophase pitch-based carbon fiber composite materials, and belongs to the technicalfield of material property testing. The method comprises the following steps of cutting and processing mechanical samples of the high-thermal-conductivity mesophase pitch-based carbon fiber compositematerials according to the corresponding test standards, and installing the samples in a reinforced sheet preparation device; preparing a resin reinforced sheet glue, and injecting the glue from theinjection port of the reinforced sheet preparation device until being completely filled; and solidifying cooling, demoulding and trimming the glue injected reinforced sheet preparation device to obtain a composite material mechanical sample. The resin reinforced sheet prepared by the invention covers and fixes a clamping section of the composite material mechanical sample, which effectively increases the contact area and friction between the reinforced sheet and the sample, makes the sample more uniformly dispersed during the test, and avoids abnormal failure due to de-bonding and slippage ofthe reinforced sheet.

The invention belongs to the field of high-performance fibers, and particularly relates to a preparation method of poly(p-phenylene benzobisoxazole) fibers. The preparation method comprises the following steps of taking frozen polyphosphoric acid powder, phosphorus pentoxide, 4,6-diaminoresorcinol hydrochloride and terephthalic acid as raw materials, putting the phosphorus pentoxide into a reaction system step by step in a reasonable proportion in a proper time period, and detecting and regulating the apparent viscosity of the materials in real time in a prepolymerization process to ensure that a prepolymer with uniform apparent viscosity is obtained; performing post-polymerization to obtain PBO spinning slurry; and performing dry-jet wet spinning and post-spinning to obtain the finished PBO fibers. The method overcomes the defects that traditional solid raw materials are poor in solvent mixing and dispersing effect, easy to agglomerate and incapable of uniformly reacting, ensures the consistency of a prepolymerization reaction end point, and reduces the process errors. The intrinsic viscosity of the polymer in the same batch in different time periods is small in change and high, the mechanical property of the fibers can be obviously improved, and the quality stability is also improved.

The invention relates to a POSS (polyhedral oligomeric silsesquioxane)-centered star copolymer flocculant and a preparation method and application thereof. An acrylamide copolymer molecular chain is connected to each silicon atom of POSS serving as the center, a star copolymer sewage treating agent is synthesized by RAFT emulsion polymerization, the number-average molecular weight is 500000-1000000, and the polydispersity index is smaller than 1.3. Compared with the prior art, the POSS-centered star copolymer flocculant and the preparation method and application thereof have advantages that (1) the POSS-centered star copolymer sewage treating agent is disclosed for the first time; (2) by RAFT emulsion polymerization, the copolymer flocculant is large in molecular weight, low in coefficientof dispersion and stable in performance; (3) the copolymer sewage treating agent structurally contains a great quantity of chelation amino groups and organic ammonium ions, so that excellent flocculation effects and high adaptability are realized.

The invention provides a hyperbranched amide hydrate kinetic inhibitor as well as a preparation method and application thereof. The structural formula of the hyperbranched amide hydrate kinetic inhibitor is represented by a formula (1), wherein the weight-average molecular weight of the hyperbranched amide hydrate kinetic inhibitor is 10000-40000, and the molecular weight distribution coefficientis 1-3. The hydrate kinetic inhibitor has the advantages of being good in solubility and small in dosage and can be applied to an oil-gas-water system, and the preparation method of the hydrate kinetic inhibitor is simple in production process and controllable in production process.

The invention provides an andrographolide nanometer suspension agent. The andrographolide nanometer suspension agent includes andrographolide particles with the effective average particle size less than 1000 nm and one or more anionic surface stabilizers. According to the nanometer suspension agent, the prescription is simple, the preparation process is simplified and controllable, industrialization is easy, the efficiency is high, preparation stability is good, and dilution resistance is achieved.

The invention provides carboxylated porous polystyrene microspheres and a preparation method thereof. The preparation method of the carboxylated porous polystyrene microspheres comprises steps as follows: 1), seed microspheres are swollen by cyclohexane; 2), the seed microspheres obtained in the step 1) are subjected to further swelling by styrene monomers, functional acrylic monomers, a crosslinking agent and a pore-foaming agent; a protective agent and an aqueous phase polymerization inhibitor are added to a system obtained after swelling in the step 2), and then a polymerization reaction isperformed; the seed microspheres are polystyrene microspheres. The carboxylated porous polystyrene microspheres obtained with the preparation method of the carboxylated porous polystyrene microspheres are not only uniform in size, but also contain rich and uniform carboxyl functional groups on the surfaces, and are of a uniform porous structure.

The invention discloses a device and a method for automatically testing a drape factor of a high performance carbon fiber. The device comprises a vertically arranged support frame, a test frame horizontally fixed on the support frame, a fiber retainer A slidably fixed on the test frame, a fiber retainer B fixed at the middle part of the test frame, a fiber yarn frame which is mounted at one end ofthe support frame and is adjacent to the fiber retainer B, a tension regulator which is fixed at one end, far away from the fiber yarn frame, of the test frame and used for providing a preset tensionfor the fiber retainer A and a level gauge fixed on the test frame; a removable distance measuring sensor is arranged at the side edge of the support frame; leveling feet are mounted at the bottom ofthe support frame; and a controller connected with the distance measuring sensor by virtue of a signal is also mounted on the support frame. The device disclosed by the invention realizes breaking test integration, detection efficiency is improved, a test result is stable, and coefficient of dispersion is small.

The invention discloses a flux-cored wire forming machine and a flux-cored wire forming process, and mainly relates to the field of flux-cored wire forming machines. The flux-cored wire forming machine comprises a steel strip U-groove rolling device and a joint closing device, and further comprises a first powder adding machine and a second powder adding machine. The flux-cored wire forming machine and the flux-cored wire forming process have the beneficial effects that the problems that in the powder filling process of a slag-free self-protection flux-cored wire, due to the fact that the density of graphite powder is smaller than that of metal powder, powder mixing is not uniform, and graphite powder in the wire is not uniformly distributed are solved; and the graphite powder and other powder are filled into the wire, the filling rate dispersion coefficient of the wire becomes small, graphite filling is more uniform, and the quality of the wire is effectively improved.

The invention discloses a control device based on the flexible triggering of a silicon controlled rectifier, and the device comprises a flue pipe and a motor disposed outside the flue pipe. The interior of the flue pipe is provided with a rotating shaft, wherein one end of the rotating shaft is fixed on the motor, and the other end of the rotating shaft is fixedly provided with a fan blade. The blade surface of the fan blade faces the mouth of the flue pipe, and the mouth of the flue pipe is provided with a solenoid valve. The device also comprises a silicon controlled rectifier switch and twoflexible pipes, and the silicon controlled rectifier switch is electrically connected with the solenoid valve. Two sides of the flue pipe are respectively provided with through holes, and the two through holes are located at the upper part of the flue pipe. Two sides of the flue pipe are respectively provided with a Venturi tube, and a throat part of each Venturi tube is provided with a water pipe. A water tank is disposed below the Venturi tubes, and the water tank is connected with the water pipes. One end of each Venturi tube is communicated with one through hole, and the end of each Venturi tube is connected with one flexible pipe. According to the scheme of the invention, water, dust and air are integrated to form water mist through the Venturi tubes, and the water mist is sprayed tothe interior of a workshop, thereby reducing the dust in the workshop, and also increasing the humidity of the workshop.

The invention relates to an ultrasonic response type polymer and nanoparticles, a preparation method and application thereof, and particularly discloses the ultrasonic response type polymer. The polymer is selected from a poly (N, N '-dimethylacrylamide-b-tetrahydropyranyl methacrylate) diblock copolymer, or a poly (N, N'-dimethylacrylamide-co-tetrahydropyranyl methacrylate) random copolymer. The invention further discloses ultrasonic response type nanoparticles, and the nanoparticles are prepared from the ultrasonic response type polymer. The nanoparticles are sensitive in ultrasonic response, the process for preparing the nanoparticles is simple, the cost is low, the cytotoxicity is small, and the universality is high.

The invention discloses modified polycarbonate with a specific terminated-structure and a preparation method and application thereof. The modified polycarbonate is prepared from a polycarbonate main chain structure and the terminated-structure. The modified polycarbonate has relatively good antibacterial property and also has excellent combination property.